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Dr. Váradi is the director of the one of the leading laboratories in ABC protein research, especially in basic biochemistry of these type of transporters. His research group has been organized in the Institute of Enzymology in 1989 focusing on the molecular mechanism of active transport proteins. He started to investigate the molecular mechanism of human multidrug ABC-transporter (MDR1 multidrug resistance protein or P-glycoprotein) and to study the membrane topology and functional domains of the second multidrug transporter, MRP1/ABCC1. He was involved in elaborating the membrane topology of ABCC1/MRP1, and identified its intracellular regulatory domain. In 2001 he initiated a project to study the function of ABCC6 protein; mutations in ABCC6 gene are associated with pseudoxanthoma elasticum. He established various in vitro ABCC6 expression systems for the very first time, demonstrated its ATP-dependent transport activity and showed that loss of activity is the cause of PXE in the case of certain mutants. He published the first study on the transcriptional regulation of the human ABCC6 gene, and determined the corresponding signal transduction pathway. In collaboration with Dr. Le Saux’ laboratory (Univ. Hawaii), he developed a preclinical animal model for pharmacological correction of disease-causing ABCC6 mutants. Currently his group is focusing on exploiting the knowledge that low plasma pyrophosphate levels underlie the clinical manifestations of pseudoxanthoma elasticum and is active to develop new treatment strategies to treat this and related mineralization disorder. His group very recently demonstrated the oral bio-availability of pyrophosphate, the endogenous inhibitor of soft tissue calcification thus opening avenues for its therapeutical application.
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#Papers: 1
#Citation: 2
H-Index: 1
G-Index: 1
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