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Jamie Spangler’s research aims to expand the repertoire of protein therapeutics by redesigning naturally occurring proteins and engineering new molecules to overcome the deficiencies of existing drugs. Integrating cutting-edge tools from structural biophysics, biomolecular engineering, and translational immunology, her research focuses on developing innovative platforms for the discovery and design of proteins that recruit novel mechanisms for disease therapy. In particular, Spangler’s group is interested in engineering antibody-based molecules that reshape immune cell behavior for targeted treatment of cancer, infectious diseases, and autoimmune disorders. The overarching goal of her interdisciplinary research program is to establish new insights into protein behavior and the extent to which it can be manipulated for medically relevant applications.
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论文共 90 篇作者统计合作学者相似作者
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JOURNAL OF IMMUNOLOGYno. 2 (2024): 225-234
Current Protocolsno. 5 (2024)
Natalie K. Livingston,John W. Hickey,Hajin Sim,Sebastian F. Salathe,Joseph Choy,Jiayuan Kong,Aliyah B. Silver,Jessica L. Stelzel, Mary O. Omotoso, Shuyi Li,Worarat Chaisawangwong, Sayantika Roy,
Current protocolsno. 5 (2024): e1061-e1061
Cell Reports Methodsno. 4 (2024): 100762-100762
Methods in molecular biology (Clifton, N.J.) (2024): 17-33
Seth D. Ludwig, Bunyarit Meksiriporn, Jiacheng Tan,Rakeeb Kureshi,Akhilesh Mishra, Kyle J. Kaeo,Angela Zhu,Georgia Stavrakis, Stephen J. Lee,David J. Schodt,Michael J. Wester,Dhiraj Kumar,
Cancer Researchno. 6_Supplement (2024): 1327-1327
Annual review of chemical and biomolecular engineering (2024)
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