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个人简介
Cellular responses to external signals begin at the plasma membrane, where the dynamic assembly of receptors or ion channels can regulate cellular activity. Membrane-enveloped viruses, including the human immunodeficiency virus (HIV) also assemble at the plasma membrane, exploiting mechanisms evolved for cellular trafficking. Despite the importance of these processes, our physical paradigm for how proteins form mesoscale assemblies is far from complete.
This is in part a consequence of technical limitations. While the organization and dynamics of membrane proteins are heterogeneous, commonly used fluorescence-based measurements lack information at the molecular scale. In contrast, single molecule measurements limited to looking at only a few molecules in a given cell lack ensemble information. Thus, the study of protein assembly has been limited by a lack of spatially resolved, dynamic information on ensembles of molecules. To overcome these obstacles, we use super-resolution fluorescence imaging techniques combined with live cell imaging and single molecule tracking to determine how the dynamics of protein assembly are coordinated.
Biography
From 2016 Associate professor, EPFL, Lausanne, Switzerland
2009-2016 Tenure-track assistant professor, EPFL, Lausanne, Switzerland
2006-2009 Post-Doctoral fellow, National Institutes of Health, Bethesda, MD, USA
2004-2006 Post-Doctoral fellow, Massachusetts Institute of Technology, Cambridge, MA, USA
1999-2004 PhD (Physics) Awarded 06/2004, Harvard University, Cambridge, MA, USA
1993-1997 Bachelors (Cum Laude) Physics & Mathematics, Rice University, Houston, TX, USA
This is in part a consequence of technical limitations. While the organization and dynamics of membrane proteins are heterogeneous, commonly used fluorescence-based measurements lack information at the molecular scale. In contrast, single molecule measurements limited to looking at only a few molecules in a given cell lack ensemble information. Thus, the study of protein assembly has been limited by a lack of spatially resolved, dynamic information on ensembles of molecules. To overcome these obstacles, we use super-resolution fluorescence imaging techniques combined with live cell imaging and single molecule tracking to determine how the dynamics of protein assembly are coordinated.
Biography
From 2016 Associate professor, EPFL, Lausanne, Switzerland
2009-2016 Tenure-track assistant professor, EPFL, Lausanne, Switzerland
2006-2009 Post-Doctoral fellow, National Institutes of Health, Bethesda, MD, USA
2004-2006 Post-Doctoral fellow, Massachusetts Institute of Technology, Cambridge, MA, USA
1999-2004 PhD (Physics) Awarded 06/2004, Harvard University, Cambridge, MA, USA
1993-1997 Bachelors (Cum Laude) Physics & Mathematics, Rice University, Houston, TX, USA
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论文共 170 篇作者统计合作学者相似作者
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Sinika Henschke,Hendrik Nolte, Judith Magoley,Tatjana Kleele,Claus Brandt,A. Christine Hausen,Claudia M. Wunderlich,Corinna A. Bauder, Philipp Aschauer,Suliana Manley,Thomas Langer,F. Thomas Wunderlich,Jens C. Bruening
ACS Photonicsno. 2 (2024): 737-744
Journal of microscopy (2024)
Nature Reviews Molecular Cell Biologyno. 6 (2024): 1-21
Matthew D. Lycas,Suliana Manley
CELL REPORTS METHODSno. 6 (2024)
biorxiv(2024)
Chen Zhang,Suliana Manley
Methods in molecular biology (Clifton, N.J.) (2024): 83-94
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作者统计
#Papers: 168
#Citation: 10646
H-Index: 43
G-Index: 103
Sociability: 6
Diversity: 0
Activity: 1
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