基本信息
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职业迁徙
个人简介
INTERESTS
cancer, pharmacology, childhood cancers, acute leukemia, apoptotic pathways in cancer cells, genomic and epigenomic analysis of childhood cancer, relapsed/resistant leukemia
RESEARCH SUMMARY
In our laboratory we focus on two major challenges facing children with acute lymphoblastic leukemia (ALL). First, in spite of dramatic improvements in outcome, one in five children will suffer a relapse and then have a poor prognosis. Second, the physical and emotional costs of therapy for those who are cured are high, with short- and long-term side effects.
Therefore, we seek to understand mechanisms of drug resistance and to identify pathways unique to the cancer cell that can serve as targets for more effective, less toxic therapeutic approaches.
We use modern genomic and epigenomic methods to understand the genesis and evolution of ALL that leads to treatment failure. We have shown that resistant cancer cells acquire novel mutations that are responsible for drug resistance. In some cases, a small clone emerges through the selective effect of chemotherapy in a model reminiscent of Darwinian evolution. However, in other cases, such mutations may have been acquired during the course of treatment. Through years of effort we have created a “genetic fingerprint” of resistant cells and have used this information to pilot novel methods to prevent and treat relapse.
Most recently we have focused on the epigenome—molecular mechanisms that control gene activity that are not related to the DNA sequence itself. We have shown that DNA modifications, including methylation and histone changes, also allow the cancer cell to overcome therapy. The availability of new agents that target these epigenetic changes may allow for more effective treatment of relapsed disease and we are exploring this approach in laboratory models.
Our laboratory encompasses the full spectrum of investigation involving basic bench research, highly translational efforts using samples from patients, and clinical trials in children with ALL.
cancer, pharmacology, childhood cancers, acute leukemia, apoptotic pathways in cancer cells, genomic and epigenomic analysis of childhood cancer, relapsed/resistant leukemia
RESEARCH SUMMARY
In our laboratory we focus on two major challenges facing children with acute lymphoblastic leukemia (ALL). First, in spite of dramatic improvements in outcome, one in five children will suffer a relapse and then have a poor prognosis. Second, the physical and emotional costs of therapy for those who are cured are high, with short- and long-term side effects.
Therefore, we seek to understand mechanisms of drug resistance and to identify pathways unique to the cancer cell that can serve as targets for more effective, less toxic therapeutic approaches.
We use modern genomic and epigenomic methods to understand the genesis and evolution of ALL that leads to treatment failure. We have shown that resistant cancer cells acquire novel mutations that are responsible for drug resistance. In some cases, a small clone emerges through the selective effect of chemotherapy in a model reminiscent of Darwinian evolution. However, in other cases, such mutations may have been acquired during the course of treatment. Through years of effort we have created a “genetic fingerprint” of resistant cells and have used this information to pilot novel methods to prevent and treat relapse.
Most recently we have focused on the epigenome—molecular mechanisms that control gene activity that are not related to the DNA sequence itself. We have shown that DNA modifications, including methylation and histone changes, also allow the cancer cell to overcome therapy. The availability of new agents that target these epigenetic changes may allow for more effective treatment of relapsed disease and we are exploring this approach in laboratory models.
Our laboratory encompasses the full spectrum of investigation involving basic bench research, highly translational efforts using samples from patients, and clinical trials in children with ALL.
研究兴趣
论文共 606 篇作者统计合作学者相似作者
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Karen R. Rabin,Meenakshi Devidas,Zhiguo Chen,Lingyun Ji,John Kairalla,Johann K. Hitzler,Jun J. Yang,Andrew J. Carroll,Nyla A. Heerema,Michael J. Borowitz,Brent L. Wood,Kathryn G. Roberts,Charles G. Mullighan,Richard C. Harvey,I-Ming Chen,Cheryl L. Willman,Shalini C. Reshmi,Julie M. Gastier-Foster,Deepa Bhojwani,Susan R. Rheingold,Kelly W. Maloney,Leonard A. Mattano,Eric C. Larsen,Reuven J. Schore,Michael J. Burke,Wanda L. Salzer,Naomi J. Winick,William L. Carroll,Elizabeth A. Raetz,Mignon L. Loh,Stephen P. Hunger,Anne L. Angiolillo
Journal of clinical oncologyno. 2 (2024): 218-227
N. J. DelRocco,M. L. Loh,M. J. Borowitz,S. Gupta,K. R. Rabin,P. Zweidler-McKay,K. W. Maloney,L. A. Mattano,E. Larsen,A. Angiolillo,R. J. Schore,M. J. Burke,W. L. Salzer,B. L. Wood,A. J. Carroll,N. A. Heerema,S. C. Reshmi,J. M. Gastier-Foster,R. Harvey,I. M. Chen,K. G. Roberts,C. G. Mullighan,C. Willman,N. Winick,W. L. Carroll, R. E. Rau,D. T. Teachey,S. P. Hunger,E. A. Raetz,M. Devidas, J. A. Kairalla
Leukemiano. 4 (2024): 720-728
Sonali Narang, Yohana Ghebrechristos,Nikki A Evensen, Nina Murrell,Sylwia Jasinski, Talia H Ostrow,David T Teachey,Elizabeth A Raetz,Timothee Lionnet,Matthew Witkowski,Iannis Aifantis,Aristotelis Tsirigos,William L Carroll
Nature Communicationsno. 1 (2024): 1-17
Heng Xu, Xujie Zhao,Deepa Bhojwani, Shuyu E, Charnise Goodings,Hui Zhang,Nita L. Seibel, Wentao Yang, Chunliang Li,William L. Carroll, William E. Evans,Jun J. Yang
openalex(2023)
Sumit Gupta,Yunfeng Dai,Zhiguo Chen,Lena E. Winestone,David T. Teachey,Kira Bona,Richard Aplenc,Karen R. Rabin,Patrick Zweidler-McKay,Andrew J. Carroll,Nyla A. Heerema,Julie Gastier-Foster,Michael J. Borowitz,Brent L. Wood,Kelly W. Maloney,Leonard A. Mattano,Eric C. Larsen,Anne L. Angiolillo,Michael J. Burke,Wanda L. Salzer,Stuart S. Winter,Patrick A. Brown,Erin M. Guest,Kimberley P. Dunsmore,John A. Kairalla,Naomi J. Winick,William L. Carroll,Elizabeth A. Raetz,Stephen P. Hunger,Mignon L. Loh,Meenakshi Devidas
Takaya Moriyama,Shuguang Liu,Jing Li, Julia Meyer,Xibin Zhao, Wentao Yang, Youming Shao,Richard J. Heath, Aleš Hnı́zda,William L. Carroll,Jun J. Yang
openalex(2023)
Joanna Pierro,Jason Saliba,Sonali Narang,Gunjan Sethia, Shella Saint Fleur-Lominy, Ashfiyah Chowdhury, Anita Qualls, Hannah Fay, Harrison L. Kilberg, Takaya Moriyama,Tori J. Fuller,David Hall,Kjeld Schmiegelow,Jun J. Yang,Mignon L. Loh,Patrick A. Brown,Jinghui Zhang,Xiaotu Ma,Aristotelis Tsirigos,Nikki A. Evensen,William L. Carroll
openalex
Wanda L. Salzer,Michael J. Burke,Meenakshi Devidas,Zhiguo (Bruce) Chen,Michael J. Borowitz,Andrew J Carroll,I-Ming L. Chen,Julie M. Gastier-Foster,Richard C. Harvey,Nyla A. Heerema,Charles G. Mullighan,Karen R. Rabin,Shalini C Reshmi,Cheryl L. Willman,Brent L. Wood,Naomi J. Winick,William L. Carroll,Elizabeth A. Raetz,Mignon L. Loh,Stephen P. Hunger
Bloodno. Supplement 1 (2023): 961-961
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作者统计
#Papers: 604
#Citation: 29616
H-Index: 86
G-Index: 163
Sociability: 8
Diversity: 0
Activity: 4
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