An In Silico Modeling Toolbox For Rapid Prototyping Of Circuits In A Biomolecular "Breadboard" System
2013 IEEE 52ND ANNUAL CONFERENCE ON DECISION AND CONTROL (CDC)(2013)
摘要
In this paper, we develop an experimentally validated MATLAB software toolbox as an accompaniment to an in vitro cell-free biomolecular "breadboard" system. The toolbox gives insight into the dynamics of unmeasured states in the cell-free system, accounting especially for resource usage. Parameter lumping and the reduced order modeling are used to maintain computational tractability and to avoid ill-conditioning. The toolbox provides a general framework for experiment planning and predictive modeling for synthetic biomolecular circuits in cell-free systems, accelerating our capacity to rationally design circuits from well characterized parts.
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关键词
circuit CAD,MATLAB software toolbox,cell-free systems,circuits rapid prototyping,computational tractability,in-silico modeling toolbox,in-vitro cell-free biomolecular breadboard system,parameter lumping,predictive modeling,reduced order modeling,resource usage,synthetic biomolecular circuits,unmeasured states,
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