MH-76, a Novel Non-Quinazoline α 1 -Adrenoceptor Antagonist, but Not Prazosin Reduces Inflammation and Improves Insulin Signaling in Adipose Tissue of Fructose-Fed Rats.
Pharmaceuticals (Basel, Switzerland)（2021）
Abstract
MH-76 may improve insulin signaling in adipose tissue by reducing the pro-inflammatory cytokine production and inhibiting the inflammatory cells recruitment. In contrast, in adipose tissue from animals treated with prazosin, the inflammatory effect was clearly enhanced.
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Key words
adipocytokines,adipose tissue,fructose-fed rats,inflammation,insulin resistance,metabolic syndrome,obesity,α1-adrenoceptors antagonist
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