Pretreatment tumour immune microenvironment predicts clinical response and prognosis of muscle-invasive bladder cancer in the neoadjuvant chemotherapy setting

Daiki Ikarashi,Shigehisa Kitano,Takashi Tsuyukubo,Kazumasa Takenouchi,Takayuki Nakayama,Hiroko Onagi,Asumi Sakaguchi,Makiko Yamashita,Hidenori Mizugaki,Shigekatsu Maekawa,Renpei Kato,Yoichiro Kato,Tamotsu Sugai,Tetsuya Nakatsura,Wataru Obara

BRITISH JOURNAL OF CANCER（2021）

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摘要

Background We examined the relationship between the tumour microenvironment and the clinical efficacy of neoadjuvant chemotherapy in patients with cT2-4aN0M0 bladder cancer using multiplex fluorescence immunohistochemistry. Methods The study retrospectively evaluated 51 patients who underwent radical cystectomy following neoadjuvant chemotherapy for cT2-4aN0M0 muscle-invasive bladder cancer. Patients were divided into responders (更多

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关键词

Bladder cancer,Cancer microenvironment,Immunoediting,Tumour biomarkers,Biomedicine,general,Cancer Research,Epidemiology,Molecular Medicine,Oncology,Drug Resistance

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