Copy Number Loss at Chromosome 14q11.2 Correlates With the Proportion of T Cells in Biopsies and Helps Identify T-Cell Neoplasms.

Arzu Saglam,Kunwar Singh,Jyoti Kumar,Sumanth Gollapudi,Soham Mukherjee,Amol Singh,Alexandra Butzmann,Lawrence Kaplan, Charambalos Andreadis,Weiyun Z Ai,Bita Fakhri, Aleksander Rajkovic,Kwun Wah Wen,Courtney Onodera,Jessica Van Ziffle,Patrick W Devine,Robert S Ohgami

Archives of pathology & laboratory medicine（2022）

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摘要

Analysis of copy number losses at the T-cell receptor α locus chr14q11.2 with targeted next-generation sequencing can potentially be used to estimate the proportion of T cells and detect T-cell neoplasms.

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关键词

chromosome,number loss,cells,t-cell

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