Top Covers of the Centennial.

HomeRadiologyVol. 306, No. 1 PreviousNext Reviews and CommentaryFree AccessEditorial–Centennial ContentTop Covers of the CentennialPeter Li , Simon Lennartz, Nikita Consul, Linda Moy, Susanna I. LeePeter Li , Simon Lennartz, Nikita Consul, Linda Moy, Susanna I. LeeAuthor AffiliationsFrom the Department of Radiology, Oregon Health and Science University Hospital Dotter Interventional Institute, 3181 SW Sam Jackson Park Rd, Portland, Oregon 97239 (P.L.); Institute for Diagnostic and Interventional Radiology, University of Cologne, Germany (S.L.); Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA (N.C, S.I.L.); Department of Radiology, New York University School of Medicine, New York, NY (L.M.).Address correspondence to P.L. (email: [email protected]).Peter Li Simon LennartzNikita ConsulLinda MoySusanna I. LeePublished Online:Dec 19 2022https://doi.org/10.1148/radiol.229033MoreSectionsPDF ToolsAdd to favoritesCiteTrack CitationsPermissionsReprints ShareShare onFacebookXLinked In IntroductionSince the journal’s inception in 1923 and as declared in its Mission Statement, Radiology has been publishing “cutting edge and impactful imaging research articles in radiology and medical imaging in order to help improve human health.” As the world’s leading journal in medical imaging, it has stayed at the forefront of radiologic education, research, and innovation. Many of the journal’s groundbreaking articles and their accompanying images are renowned for their historic impact on our profession and patient care.Imaging is at the core of our practice of radiology. At this historic junction of the journal’s transformation, with an all-time highest impact factor of 29.1 (1), we would like to acknowledge authors of Radiology’s most influential publications and commemorate the top 10 covers of the centennial. Close to 200 covers of various issues of Radiology from 2007 to 2022 were considered. Cover images were selected based on the following criteria: (a) visually engaging examples of radiology, (b) historically important innovations in imaging technology, and (c) impactful developments in medical imaging applications. Dr Linda Moy (Editor), Dr David Bluemke (Editor Emeritus), members of the Radiology editorial board, and the graduates from the Radiology In Training editorial program independently ranked their choices for the top 10 covers. The rank lists were compiled, and the final ranking was determined collaboratively (Table).Top 10 Covers in RadiologyWonders of ImagingFrom the first time we looked up at the sky through a telescope, to the first moment we saw through human tissue with the help of x-rays, our augmented vision has heralded progress in many instances of human history. The winner of the Top Covers of the Centennial award, from the article titled “Micro-CT of Early Human Development,” is a visually compelling example of this constant progress (Fig 1) (2). The authors presented ultra-high-spatial-resolution micro-CT images of a 3-mm-long 28-day excised ectopic human embryo with detailed depictions of human organ development at a resolution and time point previously unimaginable (Movie 1 [online]). Similarly, the second runner-up cover, image from the article titled “Three-dimensional in Vivo US of 7-week Embryo,” showcased unprecedented three-dimensional fetal US images of a 7-week viable human embryo (Fig 2) (3). The 7-T MRI depicting the cerebellum at near-microscopic 120-μm in-plane resolution represented the advances in imaging resolution in another modality (Fig 3) (4). Other selected covers highlighted innovations in diffusion tensor MRI (5), compressed-sensing parallel-imaging four-dimensional phase-contrast MRI (6), and dark-field chest radiography (7). These representations of cutting-edge imaging technologies were selected as Top Covers in Radiology, not necessarily because of a specific clinical context, but rather for their inherent potential to inspire future applications.Figure 1: Contrast-enhanced micro-CT at 3-µm isotropic resolution shows a 3-mm-long intact ectopic human embryo in the fallopian tube of 6-week gestation. Left, volume rendering of the micro-CT images shows that the embryo and its yolk sac are completely surrounded by trophoblast and fallopian tube. Top right, the embryo (with developing organs) and yolk sac can be clearly seen after making the surrounding tissues transparent. Bottom right, comparison with the stage 12 specimen presented in the three-dimensional atlas of human embryology shows full resemblance. Source.—Reference 2.Figure 1:Download as PowerPoint Movie 1: A 43 seconds movie of two rotating 3D reconstructions of the presented images (left and top right).Download Original Video (42.8 MB)Figure 2: In vivo three-dimensional US image of a 7-week viable human embryo. This volume-rendered image was obtained by using a transvaginal high-frequency probe (2–9 MHz) with the HD live silhouette mode (E10 Voluson; GE Healthcare). The volume of the embryo was outlined by applying the “magic cut” tool of the software. The telencephalon, diencephalon, mesencephalon, metencephalon, and myelencephalon were identified by adjusting the gain and the transparency on the US machine. Source.—Reference 3.Figure 2:Download as PowerPointFigure 3: High-resolution (A, C) magnitude and (B, D) phase gradient-echo data from two volunteers (31-year-old male and 30-year-old female volunteers, respectively) show sections crossing dentate nucleus. Phase images show expected dipole shape surrounding the dentate nucleus, which is a structure known to have a high iron concentration. Calipers (+) = positive and negative lobes of the dipole shape, respectively. White arrows = negative frequency shifts in regions superior to interfaces of gray matter and white matter. Black arrows = observable cortical gray matter structure. * = regions where white matter bundles are observable both in magnitude and phase images. Source.—Reference 4.Figure 3:Download as PowerPointThe COVID-19 PandemicWith an estimated death toll of 6.6 million (8), tens of millions struggling with disabilities from acute COVID-19 complications and post-COVID conditions, and the ongoing devastating effects on the world economy and our efforts to combat hunger, poverty, and diseases, the COVID-19 pandemic has forever changed human history and medical care. Radiology has published more than 250 articles related to COVID-19 to date, including the initial reports on the imaging manifestations of COVID-19 (9,10). In this, the journal has shown an unwavering commitment to its Vision Statements, promptly publishing “important and translatable medical imaging discoveries” and providing “meaningful information to medical imaging physicians and scientists” for the purpose of “improving health and reducing the human burden of disease.” The first runner-up cover, from the article titled “2019 Novel Coronavirus (2019-nCoV) Pneumonia,” is a selected representation of Radiology’s role throughout the pandemic (Fig 4) (11). The authors presented the chest CT imaging findings of a 41-year-old woman who was diagnosed with COVID-19 pneumonia. The accompanying three-dimensional volume-rendered reconstruction vividly depicted the multifocal ground-glass opacities and their distributions (Movie 2 [online]) in a manner that immediately portrayed the gravity of this pathologic process. Although there was no novel imaging technique involved, the cover image received well-deserved high ratings for its timeliness, clinical significance, and educational value.Figure 4: Three-dimensional volume-rendered reconstruction of chest CT images in a 41-year-old woman who presented with fever and positive polymerase chain reaction assay for the 2019 novel coronavirus (2019-nCoV). Volume-rendered reconstruction shows the distribution of the ground-glass opacities (arrows). Source.—Reference 11.Figure 4:Download as PowerPoint Movie 2 Download Original Video (22.0 MB)Pushing the EnvelopeWe treat what we see, and we treat better when we can see better. Indeed, one of Radiology’s Vision Statements asserts that the journal seeks to present “new, important, and translatable discoveries in medical imaging research that may ultimately lead to better patient care.” This vision was reflected in the other three Top Covers of the Centennial. The article titled “CT-based Airway Flow Model to Assess Ventilation in Chronic Obstructive Pulmonary Disease: A Pilot Study” described a CT-based full-scale airway network flow model for visualizing the invisible small airways (Fig 5) (12). This powerful probing tool of the lung microstructures and their functional contributions to ventilation may lead to better understanding of small airway diseases, alveoli destruction and repair, and pulmonary immune modulations. The review titled “Breast MRI: State of the Art” highlighted recent technical improvements and increased clinical utilization of breast MRI with earlier cancer detection and better patient care (13). The article titled “Ischemia and No Obstructive Stenosis (INOCA) at CT Angiography, CT Myocardial Perfusion, Invasive Coronary Angiography, and SPECT: The CORE320 Study” demonstrated how noninvasive coronary CT angiography with CT perfusion imaging can be used to tailor medical management of ischemic heart disease (14). These publications exemplified the journal’s vision in pushing the envelope of medical care with imaging innovations.Figure 5: Illustration shows the thoracic CT-based full-scale airway network flow model geometry (ParaView v5.5.2; Kitware). Each acinar unit shown as a sphere at the terminal bronchiole is interconnected with other units through the airway network. The size and color of spheres represent the scaled acinar volume and normalized acinar gas concentration. The color on the left-hand side of the image shows a lobe surface (red, right upper lobe; orange, right middle lobe; pink, right lower lobe; green, left upper lobe; purple, left lower lobe). Source.—Reference 12.Figure 5:Download as PowerPointThe editors of Radiology and the Radiology In Training would like to congratulate the authors of these selected Top Covers in Radiology. They represent the pinnacles of important innovations in radiology and impactful developments of medical imaging utilization in health care. We would also like to express our gratitude to all authors, reviewers, and staff of Radiology. Their selfless contributions continue to support Radiology in its mission to advance radiologic education, research, and innovation.Disclosures of conflicts of interest: P.L. Member of the Radiology In Training editorial board. S.L. Member of the Radiology In Training editorial board. N.C. Member of the Radiology In Training editorial board. L.M. Editor of Radiology. S.I.L. Member of the Radiology editorial board and Radiology In Training editorial board.References1. Bluemke DA. Radiology and the Impact Factor. Radiology 2022;305:247–24. Google Scholar2. Dawood Y, de Bakker BS. Micro-CT of early human development. Radiology 2020;297(1):32. Link, Google Scholar3. Boleis A, Diguisto C. Three-dimensional in vivo US of 7-week embryo. Radiology 2018;288(1):24. Link, Google Scholar4. Marques JP, van der Zwaag W, Granziera C, Krueger G, Gruetter R. Cerebellar cortical layers: In vivo visualization with structural high-field-strength MR imaging. Radiology 2010;254(3):942–948. Link, Google Scholar5. Vergoossen LWM, Jansen JFA, van Sloten TT, et al. Interplay of White Matter Hyperintensities, Cerebral Networks, and Cognitive Function in an Adult Population: Diffusion-Tensor Imaging in the Maastricht Study. Radiology 2021;298(2):384–392. Link, Google Scholar6. Hsiao A, Lustig M, Alley MT, Murphy MJ, Vasanawala SS. Evaluation of valvular insufficiency and shunts with parallel-imaging compressed-sensing 4D phase-contrast MR imaging with stereoscopic 3D velocity-fusion volume-rendered visualization. Radiology 2012;265(1):87–95. Link, Google Scholar7. Urban T, Gassert FT, Frank M, et al. Qualitative and Quantitative Assessment of Emphysema Using Dark-Field Chest Radiography. Radiology 2022;303(1):119–127. Link, Google Scholar8. Ritchie H, Mathieu E, Rodés-Guirao L, et al. Coronavirus Pandemic (COVID-19). Our World Data. 2022. https://www.ourworldindata.org/coronavirus. Accessed October 20, 2022. Google Scholar9. Kanne JP. Chest CT Findings in 2019 Novel Coronavirus (2019-nCoV) Infections from Wuhan, China: Key Points for the Radiologist. Radiology 2020;295(1):16–17. Link, Google Scholar10. Chung M, Bernheim A, Mei X, et al. CT imaging features of 2019 novel coronavirus (2019-NCoV). Radiology 2020;295(1):202–207. Link, Google Scholar11. Liu P, Tan X. 2019 Novel Coronavirus (2019-nCoV) Pneumonia. Radiology 2020;295(1):19–19. Link, Google Scholar12. Kim M, Doganay O, Matin TN, Povey T, Gleeson F V. CT-based Airway Flow Model to Assess Ventilation in Chronic Obstructive Pulmonary Disease: A pilot study. Radiology 2019;293(3):666–673. Link, Google Scholar13. Mann RM, Cho N, Moy L. Breast MRI: State of the art. Radiology 2019;292(3):520–536. Link, Google Scholar14. Schuijf JD, Matheson MB, Ostovaneh MR, et al. Ischemia and No Obstructive Stenosis (INOCA) at CT Angiography, CT Myocardial Perfusion, Invasive Coronary Angiography, and SPECT: The CORE320 Study. Radiology 2020;294(1):61–73. Link, Google ScholarArticle HistoryReceived: Oct 24 2022Revision requested: Oct 29 2022Revision received: Oct 29 2022Accepted: Oct 29 2022Published online: Dec 19 2022Published in print: Jan 2023 FiguresReferencesRelatedDetailsRecommended Articles Micro-CT of Early Human DevelopmentRadiology2020Volume: 297Issue: 1pp. 32Three-dimensional in vivo US of 7-week EmbryoRadiology2018Volume: 288Issue: 1pp. 24Evaluating Fallopian Tube Patency: What the Radiologist Needs to KnowRadioGraphics2021Volume: 41Issue: 6pp. 1876-18961Chest CT Findings in Cases from the Cruise Ship Diamond Princess with Coronavirus Disease (COVID-19)Radiology: Cardiothoracic Imaging2020Volume: 2Issue: 2CT for Evaluation of HemoptysisRadioGraphics2021Volume: 41Issue: 3pp. 742-761See More RSNA Education Exhibits Taming the Broncho: An Imaging Guide to Acute Bronchial DisordersDigital Posters2022Imaging Features Of The Ectopic Tissues With Embryologic Approach For Correct Diagnosis.Digital Posters2021Malformation Maladies - Magnetic Resonance Imaging In Congenital Malformations Of BrainDigital Posters2021 RSNA Case Collection Primary Fallopian Tube CarcinomaRSNA Case Collection2022Isolated Fallopian Tube Torsion RSNA Case Collection2021Early pelvic inflammatory diseaseRSNA Case Collection2020 Vol. 306, No. 1 Metrics Altmetric Score PDF download