Faecal biomarkers of neutrophil and eosinophil origin reflect the response to biological therapy and corticosteroids in patients with IBD.

Maria Ling Lundström,Christer Peterson, Maria Lampinen,Charlotte R H Hedin,Åsa V Keita,Robert Kruse,Maria K Magnusson,Carl Mårten Lindqvist,Dirk Repsilber,Mauro D'Amato,Henrik Hjortswang,Hans Strid,Anders Rönnblom,Johan D Söderholm,Lena Öhman,Per Venge,Jonas Halfvarson,Marie Carlson

Clinical and translational gastroenterology（2023）

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摘要

Faecal MPO, HNL, and EDN are all promising biomarkers for assessing the treatment outcome of biologics in patients with IBD. Faecal levels of EDN and HNL are significantly affected by corticosteroids indicating a greater sensitivity to the effects of corticosteroids compared with FC and MPO.

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