Genetic distance informs polygenic score predictive accuracy.
Trends in genetics : TIG(2023)
摘要
Polygenic scores (PGSs) aggregate the effects of variants across the genome to estimate genetic liability, but have lower performance in external study populations. A new study by Ding et al. has applied a novel framework to estimate the individual-level predictive accuracy of PGSs, and demonstrates that performance reduction occurs linearly with genetic distance.
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关键词
genetic distance,polygenic score,accuracy,predictive
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