Therapy of Locally Advanced and Oligometastatic Pancreatic Adenocarcinoma

Simple Summary Pancreatic cancer remains a lethal disease despite a wide variety of therapeutic options. This review was initiated to provide an overview of existing therapies and future perspectives regarding the therapy of a patient collective that cannot undergo immediate curative treatment by surgery due to the extent of the disease at diagnosis.Abstract Pancreatic adenocarcinoma is a lethal disease, and surgical resection remains the only curative treatment option. Unfortunately, upon primary diagnosis, only 15-20% of all patients with pancreatic ductal adenocarcinoma (PDAC) have localized disease that is eligible for operation. The remainder of patients either have borderline resectable or locally advanced disease or present with distant metastasis. In this review, we present a comprehensive overview regarding the current strategies and future directions in the multimodal therapy of locally advanced and oligometastasized pancreatic adenocarcinoma and discuss the benefit of surgery following neoadjuvant therapy in these patients.