Ozanimod Differentially Impacts Circulating Lymphocyte Subsets in Patients with Moderately to Severely Active Crohn’s Disease
Digestive diseases and sciences(2024)
摘要
Ozanimod showed efficacy and safety in the phase 2 STEPSTONE study conducted in patients with moderately to severely active Crohn’s disease. This analysis assessed the effects of ozanimod on circulating lymphocytes in Crohn’s disease. Patients received ozanimod 0.92 mg for 12 weeks. Lymphocyte subtypes were evaluated using multicolor flow analysis on blood samples collected before treatment and on Week 12. Absolute lymphocyte count changes were analyzed by Wilcoxon signed rank tests. Disease activity changes and efficacy outcomes were evaluated at Week 12, and associations with lymphocyte subtype levels were assessed using Spearman’s correlation and logistic regression. Reductions in median total T, Th, and cytotoxic T cells occurred at Week 12 (45.4
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关键词
Lymphocytes,T lymphocytes,B lymphocytes,Crohn disease
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