湖南食品药品职业学院是经湖南省人民政府批准设立、公办的全日制高等院校，由省食品药品监督管理局主管，教育业务由省教育厅管理。 学院前身是创办于1979年的湖南省医药技工学校，2011年3月经湖南省人民政府批准升格为湖南食品药品职业学院。 据2020年6月学校官网显示，现有长沙市含浦、圭塘及洞井3个校区，总占地面积357亩，建筑面积15.1万平方米。其中，含浦新校区于2012年投入使用，占地面积303亩，教学、生活设施设备齐全。学院现有教职工329人，其中教师203人，高级职称80人，中级职称101人，双师素质教师80人。 经过外引内培，现已建设成一支以中青年教师为主体，学历、职称、专业结构合理，综合素质全面的师资队伍。学院拥有GMP模拟制药车间、GSP模拟药房等实验实训室134间，校内一体化综合实训室25个，校外实习实训基地112个。 经过30余年的积累，学院已建成药学、医疗器械和食品类专业的高技能人才培养体系。现正致力于将我院建设成为湖南乃至中部地区同层次院校中有较大影响力的高素质技能型人才培养基地、医药行业从业人员重点培训基地和生物医药产业技术服务中心。
Objective: This study aimed to establish a method for the simultaneous determination of 80 veterinary drugs including quinolones, sulfonamides, receptor agonists, glucocorticoids, macrolides, tetracyclines, antiviral drugs in chicken by QuEChERS-ultra high performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS）. Methods: The samples were extracted by 1% formic acid acetonitrile aqueous solution, purified by QuEChERS multi-veterinary drug residue purification column, detected by ultra-high performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS） multi-reaction monitoring mode, and quantified by matrix standard curve external standard method. Results: The results showed that 80 kinds of veterinary drugs were highly responsive under specific mass spectrometry conditions, and the samples were sensitive to detection under the conditions of mass spectrometry without interference of foreign peaks. The correlation coefficient of 80 drugs were greater than 0.99 in the range of 5.0~100 μg/L, with good linearity. The detection limit of 80 veterinary drugs were 1.0 μg/kg. The average recovery of spiked concentration of 2.0, 5.0, 10.0 μg/kg in the sample was 62.2%~106.8%; RSD was 2.07%~10.85%. Conclusion: The recovery rate of 80 drugs in the samples conformed to the standard requirements of GB/T 27404—2008 Code for Laboratory Quality Control-Physical and Chemical Testing of Food. The method was suitable for the screening and determination of 80 veterinary drug residues in chicken.
