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Meta-epidemiology is an emerging research approach that incorporates systematic reviews(SRs)or Meta-analyses to examine the impact of specific characteristics of clinical studies on observed effects.It aims to identify potential sources of bias and to accurately estimate between-trial heterogeneity and changes in average bias within Meta-analyses,thereby enhancing the quality of primary studies and SRs.As the methodological framework of Meta-epidemiology continues to mature and the demand for precise evidence linking trial characteristics with heterogeneity increases in the field of TCM,the application value of Meta-epidemiology has become increasingly prominent.This article systematically elaborates on the core methodological characteristics of Meta-epidemiological studies that take SRs or Meta-analyses as the unit of analysis.By integrating multidimensional visual analyses,including publication volume characteristics,national and regional collaboration networks,author collaboration networks,and keyword co-occurrence and clustering,the development trends and research hotspots in this field are comprehensively mapped.The results indicate that,in recent years,Meta-epidemiological research has developed rapidly worldwide,with increasingly close international collaboration between the United Kingdom and the United States.Research themes have mostly focused on disease areas such as osteoarthritis,acute exacerbations of chronic obstructive pulmonary disease,and cardiovascular diseases.On this basis,the article further explores the application value of Meta-epidemiology in the field of TCM.Using acupuncture and moxibustion as an example,it analyzes the adaptability of this approach in addressing key issues in TCM clinical trials,such as high heterogeneity and difficulties in risk-of-bias assessment.The study aims to establish a more robust methodological framework for TCM research and to support the generation of higher-quality evidence and more reliable inference.
Objective To observe the effect of scalp acupuncture points including Shenting(GV24),Benshen(GB13)and Sishen-cong(EX-HN1)combined with computer-assisted training on memory impairment after stroke. Methods From May,2023 to December,2024,62 patients with post-stroke memory dysfunction who received rehabilita-tion treatment in Beijing Bo'ai Hospital were selected and divided into control group(n=31)and observation group(n=31)randomly.Both groups received conventional treatment and computer-assisted training,while the observation group received additional scalp acupuncture treatment,for four weeks.They were evaluated with Montreal Cognitive Assessment(MoCA),auditory memory span,and modified Barthel Index(MBI)before and after treatment. Results No adverse reaction occured during treatment.After treatment,the total score of MoCA and the memory dimen-sion score,and auditory memory span score improved in both groups(|t|>3.838,P<0.001),and the d-value was more in the observation group than in the control group(|t|>2.160,P<0.05);the score of MBI improved in both groups(|t|>7.471,P<0.001),however,there was no significant difference between two groups(P>0.05). Conclusion Computer-assisted training could significantly improve the cognitive function of patients with post-stroke memory dysfunction,especially the memory function,and is more effective while combining with scalp acupunc-ture.
OBJECTIVE To investigate the improvement effect and potential mechanism of Qingxue xiaozhi jiangtang formula on insulin resistance (IR) in type 2 diabetes mellitus (T2DM) rats.METHODS T2DM rat model was established by intraperitoneal injection of 30 mg/kg streptozotocin combined with high-fat and high-sugar diet.The rats were randomly divided into normal control group,model group,Qingxue xiaozhi jiangtang formula low-dose and high-dose groups (6.525,13.05 g/kg,calculated by raw material) and metformin group (positive control,0.18 g/kg),with 8 rats in each group.Administration groups were given relevant medicine intragastrically;normal control group and model group were given constant volume of normal saline intragastrically,once a day,for consecutive 6 weeks.Body mass and fasting blood glucose (FBG) were determined,and oral glucose tolerance test was conducted.Serum fasting insulin (FINS) level was measured to calculate the insulin resistance index (HOMA-IR) and insulin sensitivity index (ISI).Additionally,the level of serum lipids,liver function,oxidative stress indicators and inflammatory factors were assessed.The phosphorylation levels of kinase R-like endoplasmic reticulum kinase (PERK) and forkhead box O1 (FOXO1) protein in liver tissue of rats were determined.RESULTS Compared with model group,the body weight,ISI,the levels of high-density lipoprotein cholesterol and superoxide dismutase were increased significantly in Qingxue xiaozhi jiangtang formula high-dose group and metformin group (P<0.05);FBG,blood glucose level at 120 minutes of glucose loading,area under the curve of glucose,FINS,HOMA-IR,low-density lipoprotein cholesterol,total cholesterol,triglyceride,alanine transaminase,aspartate transaminase,alkaline phosphatase,malondialdehyde,interleukin-6,tumor necrosis factor-α,and C-reactive protein levels were significantly reduced (P<0.05);the pathological damage of liver tissue had significantly improved,and the phosphorylation levels of PERK and FOXO1 proteins in liver tissue were significantly decreased (P<0.05).CONCLUSIONS Qingxue xiaozhi jiangtang formula can regulate glucose and lipid metabolism,inflammation factor and oxidative stress levels,and alleviate insulin resistance in T2DM rats.Its mechanism of action may be related to the inhibition of the PERK/FOXO1 signaling pathway.
