从事茶叶及中草药活性成分、食品、饮料、保健品及其质量管理和质量控制技术的研发、中试，转让研发成果，提供相关技术咨询和技术服务。实验室设备、仪器仪表、化工产品及原料（除危险化学品、监控化学品、烟花爆竹、民用爆炸物品、易制毒化学品）、实验室用品及耗材、塑料制品、包装材料、玻璃仪器、金属、五金交电、文教用品、劳防用品、电子产品、办公设备的批发、进出口、佣金代理（拍卖除外）；实验室设备、仪器仪表的安装、维修（以上项目限上门）。【依法须经批准的项目，经相关部门批准后方可开展经营活动】
Objective： To study the effect of hemp seed and algal oil mixture in lowering blood lipids, and provide the theoretical basis for the utilization of hemp seed and algal oil mixture in food. Methods: 113 hyperlipidemia adult volunteers were selected and randomly divided into two groups, namely the experiment group and the control group. The subjects in the experiment group were given gelatinized confections for 90 days, while subjects in the control group were given a placebo. The levels of Serum total cholesterol(TC), Triglyceride(TG), High-density lipoprotein cholesterol(HDL-C), Low-density lipoprotein cholesterol(LDL-C)and physiological and biochemical parameters were measured before and after trial. For the experiment group, hepatobiliary ultrasonography, carotid plaque ultrasonography, fasting blood glucose, glycosylated hemoglobin, inflammatory indicators tumor necrosis factor-α, interleukin-6, C-reactive protein and antioxidant indicators superoxide dismutase, malondialdehyde, glutathione peroxidase were detected. Results: At the end of the human trial, compared with the control group, serum TC, TG and LDL-C levels of the experiment group decreased significantly(P＜0.05). And the rate of effective lowering lipid level is 30.4% in the experiment group at the end of trials. No abnormal effect was observed in liver function, renal function and hematological examination. In the experiment group, the levels of hBA1c and IL-6 were decreased (P＜0.05), SOD and GSH-Px activities increased (P＜0.01), the improvement rate of carotid plaque and fatty liver was 33.3% and 39.3%, respectively. Conclusion: Hemp seed and algal oil mixture tested in the study have a good function of lowering blood lipid in humans with an acceptable safety profile, which may be related to anti-inflammatory and antioxidant effects.
In order to investigate the anti-photoaging effect and mechanism of tomato and aronia extracts, the effects of tomato extract and aronia extract on apoptosis, Reactive oxygen species (ROS) and prostaglandin E2 (PGE2) were studied in UVB-irradiated HaCaT cells. Hematoxylin-eosin (HE) staining was used to evaluate the anti-photoaging effect of tomato and aronia complex (LA) on skin photoaging in UVB-irradiated ICR mice. The activity of superoxide dismutase (SOD), the level of malondialdehyde (MDA) and the expression of pro-inflammatory factors interleukin-1β (IL-1β), interleukin-6 (IL-6), cyclooxygenase-2 (COX-2) and tumor necrosis factor-α (TNF-α) were detected. The results showed that tomato extract and aronia extract were not cytotoxic to HaCaT cells. In the photoaging model of HaCaT cells, compared with the model group, the number of apoptotic cells in 100 μg/mL tomato extract group and 30μg/mL aronia extract group were significantly decreased (P<0.05). Aronia extract (100 μg/mL) significantly decreased ROS level (P<0.01). At 100 μg/mL, PEG2 was significantly decreased in both tomato and aronia extract groups (P<0.05). Compared with the model group, LA treatment group resulted in a significant reduction in dermal thickness (P<0.01) and MDA levels (P<0.01), and a significant increase in SOD activity (P<0.01) in skin tissue, while the proinflammatory factors IL-6, COX-2 and TNF-α were all significantly decreased (P<0.05). Tomato and aronia complex can improve oxidative stress and inflammation induced by UVB, and has the effect of anti-photoaging.
