为人民身体健康提供医疗与护理保健服务。预防保健科、内科、外科、妇产科、儿科、儿童保健科、眼科、耳鼻咽喉科、口腔科、皮肤科、医疗美容科、传染科、结核病科、肿瘤科、急诊医学科、康复医学科、职业病科、麻醉科、医学检验科、病理科、医学影像科、中医科、健康门诊、一门诊、二门诊、三门诊、理疗科、药剂科、高压氧治疗专业的诊疗与护理;(具体科目设置见《医疗机构执业许可证》)·医疗人员的培训教育
Objective:To analyze the correlation between serum thyroid hormone levels and low birth weight infants in pregnant women with hypothyroidism in the first, second and third trimester.Methods:A total of 150 pregnant women with hypothyroidism were selected as the observation group, and 150 pregnant women with normal pregnancy during the same period were selected as the control group, 50 cases in the first trimester, 50 cases in the second trimester and 50 cases in the third trimester.Serum thyroid hormone levels, including free triiodothyronine（FT3）,free thyroxine（FT4） and thyroid stimulating hormone（TSH）,were detected in the two groups.Pearson correlation was used to analyze the relationship between serum thyroid hormone levels and neonatal birth weight.Receiver operating characteristic（ROC） curve was used to analyze the predictive efficacy of serum thyroid hormone levels in low birth weight infants.Results:There were no significant differences in the levels of FT3,FT4 and TSH in the control group during different pregnancies（all P＞0.05）.The levels of FT3 in the first, second and third trimester in the observation group were lower than those in the control group, and the levels of TSH were higher than those in the control group（all P＜0.05）.Pearson correlation analysis showed that FT3 levels in the first, second and third trimesters were positively correlated with neonatal birth weight, and TSH levels were negatively correlated with neonatal birth weight（all P＜0.05）.Multivariate Logistic regression analysis showed that both FT3 and TSH in the second trimester were independent predictors of low birth weight（all P＞0.05）.According to the ROC curve analysis, the area under the ROC curve（AUC） of FT3 combined with TSH in the second trimester in predicting low birth weight infants was 0.900.Conclusion:The serum FT3 and TSH of pregnant women with hypothyroidism in the first, second and third trimester are closely related to neonatal birth weight, the combination of FT3 and TSH in the second trimester is effective in predicting low birth weight infants.
