Beijing Chaoyang Hospital (simplified Chinese: 北京朝阳医院; traditional Chinese: 北京朝陽醫院; pinyin: Běijīng Cháoyáng Yīyuàn) is a hospital in Chaoyang District, Beijing. It is subordinate to the Beijing Municipal Healthcare Bureau. It is the third clinical hospital of the medical school of Capital Medical University. It has two campuses, the Main Campus and the Jingxi Campus, with a combined floor space of 210,000 square metres (2,300,000 sq ft) sitting on an area of 102,800 square metres (1,107,000 sq ft). The hospital has 3,600 medical and support staff members and room for 1,910 patients.The hospital was founded on February 24, 1958.
Objective: This study aimed to investigate the correlation between transfer time (the duration from loading embryos into catheters to expulsion into the uterine cavity) during embryo transfer and the clinical pregnancy rate (CPR). Methods: Data were collected from 486 women who underwent 486 vitrified-warmed cycles, transferring two cleavage embryos cryopreserved with good morphological quality at a single center. The cohort was stratified into tertiles based on transfer time in seconds: T1 (15-27 seconds), T2 (28-33 seconds), and T3 (34-81 seconds). Associations between transfer time and pregnancy outcomes were evaluated using multivariable linear regression analysis. Results: Our findings revealed CPRs of 55.6%, 51.2%, and 41.1% across the tertiles, while implantation rates were 35.8%, 36.3%, and 25.5%, respectively. Transfer time was not independently associated with clinical pregnancy (odds ratio [OR] = 0.98, 95% confidence interval [CI] = 0.96-1.01). Following adjustment for potential confounders, the effect size (OR) remained 0.99 (95% CI = 0.97-1.01). Compared to the T1 (reference) group, the CPR in the T3 group was significantly lower (P <0.05). Conclusions: Our study provides evidence on the impact of transfer time on pregnancy outcomes, with prolonged transfer times adversely affecting CPRs.
Introduction:Gastroesophageal reflux disease (GERD) is a common condition involving recurrent reflux of stomach contents, causing symptoms and complications that impact quality of life. This study aimed to assess the global GERD burden from 1990 to 2021. Methods:We used the Global Burden of Disease 2021 data to analyze the incidence, prevalence, and years lived with disability (YLDs) for GERD across 204 countries. We estimated the population-level distributions by age and sex, using age-standardized incidence rate (ASIR) and age-standardized YLDs (ASYLDs). The average annual percent change (AAPC) in incidence, prevalence, and YLDs was calculated along with 95% uncertainty intervals (UIs). Results:In 2021, the global ASIR of GERD was 3881.86 per 100 000, reflecting an AAPC increase of 3.80% since 1990. The prevalence also increased, with an AAPC of 3.38%, reaching 9838.60 per 100 000. Global ASYLDs rose to 75.56 per 100 000, showing an AAPC increase of 3.49%. GERD burden varied by region; high-income areas like North America and East Asia saw declines, while Western Sub-Saharan Africa and Central Europe showed increases. India and China had the highest recorded incidences, with 36 567 410 and 20 863 747, respectively. Decomposition analyses revealed that population growth and aging contributed most to the increase in YLDs. Conclusion:The global GERD burden significantly increased from 1990 to 2021, especially in low and middle-income regions. This highlights the urgent need for enhanced public health measures, early diagnosis, and improved healthcare access to manage the growing disease burden and improve patient outcomes.
ABSTRACT Purpose To develop a vessel wall imaging (VWI)‐dedicated image restoration model enabling high‐resolution whole‐brain VWI in under 6 min. Methods A transformer‐based 2.5D model was trained in a supervised manner to enhance the image quality of CAIPIRINHA 2 × 2‐accelerated VWI acquisitions to a level comparable to that of GRAPPA twofold‐accelerated scans. The majority of k ‐space data used for training and testing were acquired on a Siemens 3 T system equipped with a standard 20‐channel head–neck coil. Region‐of‐interest fine‐tuning and slice‐to‐volume reconstruction were devised to balance global structural fidelity with local vascular precision and 3D continuity. Model performance was evaluated both quantitatively and qualitatively through single‐center retrospective testing and prospective testing in multi‐center, generalized settings. Integration of the model into the vendor's inline image reconstruction pipeline was also investigated. Results Compared with the input images, model outputs improved peak SNR by more than 7 dB and structural similarity index measure by 0.19 in the retrospective test set. When applied to CAIPIRINHA fourfold‐accelerated data that otherwise underwent offline or inline GRAPPA reconstruction, the model significantly enhanced vessel wall SNR, wall‐to‐lumen CNR, wall‐to‐cerebrospinal fluid CNR, and image quality scores. These improvements were sustained in an independent cohort from different institutions and reproduced in a dataset acquired with smaller field of view and a 64‐channel coil, supporting the model's robustness and generalizability. Conclusion The proposed inline‐integrable image restoration model enables clinically viable whole‐brain VWI in under 6 min using standard 20‐channel coils, offering a practical approach to improve patient throughput without compromising diagnostic quality.
Preeclampsia (PE) is currently one of the major causes of health threats and can lead to maternal and fetal death. The onset of PE is attributed to cellular dysfunction resulting from disruption of the molecular regulatory network in trophoblast cells. We discovered that FOXO1 was downregulated in the placentas of patients with preeclampsia. To elucidate the involvement of FOXO1 in the development of preeclampsia, we generated trophoblast cell lines with manipulated levels of FOXO1, either through overexpression or knockdown, to elucidate its biological function and underlying mechanisms. FOXO1 expression is positively correlated with the invasive, migratory, and proliferative abilities of trophoblast cells. Transcriptome sequencing analysis revealed that DUSP9 is a potential target gene of FOXO1. The suppression of DUSP9 expression markedly diminishes the invasive, migratory, and proliferative abilities of trophoblast cells. Silencing DUSP9 in trophoblast cells with elevated FOXO1 levels can attenuate their physiological functions. We found that overexpression/inhibition of FOXO1 can correspondingly suppress/activate the p38/JNK signaling pathway. Notably, the inhibition of DUSP9 in the context of FOXO1 overexpression can activate the p38/JNK signaling pathway. FOXO1 modulates the biological functions of trophoblast cells in preeclampsia via the DUSP9/p38/JNK signaling pathway.
Small animal models are essential for ophthalmic research because they enable controlled investigation of disease mechanisms and preclinical evaluation of new therapies.Optical Coherence Tomography(OCT)is a noninvasive,high-resolution imaging modality widely used for in vivo visualization of retinal microstructures.However,most OCT systems for small-animal fundus imaging are adapted from human-eye platforms and do not fully accommodate the anatomical and optical characteristics of small animal eyes.In particular,the much smaller pupil diameter of small animals makes wide-angle scanning highly susceptible to beam clipping and field restriction.A major cause of this limitation is the spatial separation of the pivot points associated with two orthogonal scanning directions in traditional galvanometric scanners.This study aimed to develop a dedicated OCT scanner for small-animal fundus imaging by integrating a 4f system into the sample arm to eliminate pivot-point separation and improve pupil matching. The optical characteristics of human and small-animal eyes were first analyzed,focusing on pupil size and its effect on beam transmission during scanning.Then,two OCT sample-arm configurations were compared using optical simulation software:a traditional scanner consisting of a two-dimensional galvanometer and a telescope,and a proposed scanner composed of two one-dimensional galvanometers,a 4f system,and the same telescope.In the proposed scanner,the 4f system relayed the beam deflections of the orthogonal galvanometers and mapped their pivot points onto the same spatial location,thereby removing the pivot-point separation of the traditional scheme.Simulations were performed with a Gaussian input beam,and galvanometer deflection angles were set within-8° to 8° to visualize beam propagation,pivot positions,and retinal spot distributions.For experimental validation,a SD-OCT system was constructed.Comparative in vivo retinal imaging was performed in a guinea pig using the same OCT platform alternately configured with the traditional and proposed scanners.The maximum scanning angle of the proposed scanner was also estimated in air by geometric-optics measurement based on beam displacement on a screen. Optical simulations showed that the traditional scanner exhibited a clear separation between the pivot points of the two scanning directions,with a distance of 5.8 mm.When one pivot point was aligned with the pupil plane,the beam corresponding to the other scanning direction was partially blocked by the small pupil,resulting in asymmetric beam transmission and an elliptical retinal Field of View(FOV).In contrast,the proposed scanner successfully merged the two pivot points through the 4f system,enabling the unified pivot to coincide with the pupil plane and maximizing pupil utilization.The simulated maximum entrance pupil angle reached 56.0°.Experimental results were consistent with the simulations.The measured full scanning angle in air was 56.7°.In vivo guinea pig imaging further demonstrated the superiority of the proposed scanner.Whereas the traditional scanner produced an elliptical field with limited retinal coverage,the proposed scanner generated a larger and more regular circular FOV.The in vivo results further showed reduced edge truncation,alleviated signal cutoff caused by pupil obstruction,and broader visualization of retinal structures.These findings confirmed that the 4f-based design effectively overcame the field limitation induced by pivot-point separation in traditional systems. A dedicated OCT scanner for small-animal fundus imaging was developed and validated by integrating a 4f system into the sample arm.By eliminating the separation between orthogonal scanning pivot points and aligning the merged pivot with the pupil plane,the proposed scanner mitigates beam clipping caused by the small pupils of animal eyes.Both simulation and in vivo experiments demonstrated that,compared with a traditional scanner,the proposed system achieves a substantially larger and more regular retinal FOV,with a maximum entrance pupil angle of 56.0°.This work provides a practical and effective solution for wide-field OCT imaging of small-animal fundi.
