Chirality is often discussed in chemistry as if it were a matter of degree: molecules are described as ‘more’ or ‘less’ chiral depending on the number of stereogenic elements, the magnitude of helical twist, or the extent of structural distortion. From a mathematical perspective, however, chirality is strictly binary—a structure is either superimposable on its mirror image or it is not. This apparent contradiction reflects a deeper issue: the classifications commonly used in chemistry obscure a more fundamental distinction. In this Perspective, we revisit molecular chirality through the lens of geometry and topology. We demonstrate that the vast majority of familiar stereochemical motifs—classified as central, axial, planar, or helical chirality—are topologically trivial and belong to a single class in which enantiomers are interconvertible by continuous deformation of the molecular geometry, without bond breaking. But there exists a fundamentally distinct class: topologically chiral molecules, such as certain interlocked and knotted architectures, whose enantiomers cannot be interconverted by any continuous deformation, even under the assumption of complete conformational flexibility. Viewed from this perspective, while some classification remains useful, extensive classification risks adding unnecessary complexity without improving our understanding of how chirality functions in practice. What ultimately matters to chemists is identifying the conditions under which chirality can be observed, preserved, and used. This Perspective does not aim to provide a comprehensive, mathematically rigorous unification of stereochemical classes, but rather to illustrate, through selected model systems, the relationship between topological chirality and classical, rigidly chiral frameworks.
Halide perovskites (HPs) have developed into a promising material platform for investigating spin-optoelectronic applications. A key obstacle for real-world implementation, however, is achieving long electron spin lifetimes under ambient conditions. This review focuses on recent experimental insights into spin relaxation pathways in HP semiconductors. We begin by outlining the four major spin-relaxation mechanisms and highlight the characteristic magnetic-field and temperature dependencies associated with each. These mechanistic ‘fingerprints’ provide an experimental framework for identifying dominant relaxation channels in HPs. We then survey how different HP compositions, crystal structures, and dimensionalities influence which mechanisms prevail. Finally, we summarize key spectroscopic techniques capable of probing such spin depolarization dynamics and offer complementary information.
This account highlights recent contributions from the Lacour group at the interface of chirality and light-matter interactions. Cationic helicenes, ylide-derived macrocycles and heterocycles, and boramidines are presented as complementary chiral platforms for tuning photophysical and chiroptical properties, notably ECD and CPL. Resolution methods and chiral ion pairing further extend these studies to advanced regimes, from supramolecular assemblies to ultrafast and X-ray spectroscopy.
