Based on the accelerating global aging process and the increasing prevalence of common and prevalent orthopedic disorders,artificial intelligence(Al),as a core technology in computer science,has penetrated into all processes of orthopedic medical care.AI's use in orthopedics will also to lead a new round of technological revolution and achieve breakthrough developments.This study comprehensively summarizes the innovative achievements and technological breakthroughs of AI technology from five perspectives-disease prevention,diagnosis,surgery,rehabilitation,and pharmaceutical development in orthopedic diseases,elaborating on the current application status and limitations of the technology.Special emphasis is placed on issues such as data security,algorithm credibility,and clinical translation,and corresponding solutions to these three core problems are proposed respectively.Combined with specific clinical transformation paths and research trajectory,the development prospects of multimodal fusion and cross-disciplinary collaboration are prospected.In the fields of precision diagnosis and treatment of fractures,robot-assisted surgery,and personalized rehabilitation,AI outperforms conventional clinical approaches.However,factors such as the lack of comprehensive database retrieval,large-scale clinical validation,and immature technology have hindered the large-scale application and implementation of AI.This article provides a systematic summary for the technological transformation and academic development of AI in orthopedics,and also looks ahead to new directions and prospects.
Diabetic kidney disease(DKD),one of the most severe microvascular complications of diabetes,has become the leading cause of chronic kidney disease and end-stage kidney disease in China. Branched-chain amino acid(BCAA),essential amino acid in humans,constitutes an important part of amino acid metabolism. Accumulating evidence indicates that abnormal BCAA metabolism plays a critical role in the initiation and progression of DKD and is closely related to the injury of glomerular podocytes and renal tubular epithelial cells,whereas the relevant pathogenic mechanisms have not been systematically summarized. This review elaborates on BCAA metabolic pathways and the mechanisms by which disturbed BCAA metabolism induces renal damage in DKD,and discusses the therapeutic potential of BCAA and their key metabolic enzymes as intervention targets,so as to provide novel ideas for clinical treatment of DKD.
Objective To explore the efficacy and safety of Lingjiao Gouteng Decoction combined with pidotimod in the treatment of children with hand,foot,and mouth disease and to provide a reference for clinical treatment.Methods A total of 80 children with hand,foot,and mouth disease admitted to Wuhan Eighth Hospital from June 2019 to June 2022 were selected as the research subjects,and were randomly divided into two groups using a random number table method.The control group(n=40)was treated with pidotimod for one week continuously,and the study group(n=40)was treated with Lingjiao Gouteng Decoction for the first three days on the basis of pidotimod treatment in the control group.The clinical efficacy,T lymphocyte subsets,serum levels of neuron-specific enolase(NSE)and astrocyte derived protein(S100B),time to clinical symptom resolution,and medication safety were compared between two groups.Results After a week of treatment,the total effective rate in the study group was higher than that in the control group(95.00％vs 75.00％,x2=6.275,P=0.012).After treatment,CD8+in two groups was lower than that before treatment,while CD3+,CD4+,and CD4+/CD8+were higher than those before treatment(P＜0.05).CD3+,CD4+,and CD4+/CD8+in the study group were higher than those in the control group after treatment,and CD8+was lower than that in the control group after treatment(P＜0.05).After treatment,the levels of serum NSE and S100B in two groups were lower than before treatment(P＜0.05),and the levels in the study group were lower than in the control group(P＜0.05).Compared to those on pidotimod alone,the time to rash dissipation,ulcer healing and fever reduction in the study group were significantly reduced(P＜0.05).None of the subjects had serious adverse reactions.Conclusion The Lingjiao Gouteng Decoction combined with pidotimod is effective in treating children with hand,foot,and mouth disease.It can improve the immune function,protect brain nerves,quickly dissipate herpes,eliminate ulcers,reduce fever,and has no obvious adverse reactions.
Colon cancer is one of the top three malignant tumors worldwide. The most common site of distant metastasis is the liver.Early detection of metachronous liver metastasis after surgery and the adoption of reasonable treatment strategies are particularly important. The clinical management of metachronous liver metastasis from colon cancer has gradually evolved from a single lesion-oriented treatment to an integrated diagnosis and treatment model that integrates multidisciplinary and multi-omics information. The established diagnosis and treatment system still faces core challenges in advancing towards"precision medicine",including incomplete guideline details and difficulty in standardizing individualized treatment plans. This article systematically reviews the definition,diagnosis,treatment and risk factors of metachronous liver metastasis from colon cancer,aiming to provide a reference for early prediction and comprehensive management in clinical practice.
Objective To evaluate the accuracy of acetabular anterior column screw placement under robotic navigation,so as to provide a reference for clinical treatment.Methods A total of 78 patients who underwent anterior column screw placement with robotic navigation at Gansu Provincial Hospital from January 2022 to January 2024 were retrospectively collected.The patients were divided into observation group(44 cases)and control group(34 cases)according to different surgical methods.Screws were placed under robotic navigation in the observation group,while screws were inserted freehand under fluoroscopic guidance in the control group.Postoperative examinations were completed.Excellent placement was defined as accurate screw position according to the accuracy evaluation criteria.The numbers of accurately placed anterograde anterior column screws,retrograde anterior column screws and total screws were counted,and the screw placement accuracy rates were compared between the two groups.Results Compared with the control group,the observation group showed slightly higher accuracy placement rates of anterograde anterior column screws(92.0％vs 80.0％,x2=0.54,P=0.462),retrograde anterior column screws(94.7％vs 85.7％,P=0.561),and overall screws(93.2％vs 82.4％,x2=1.27,P=0.260),but none of these differences were statistically significant.Conclusion Compared with freehand percutaneous screw insertion under fluoroscopy,the accuracy of percutaneous screw placement assisted by robotic navigation is somewhat higher,but the difference is not statistically significant.
