Objective To assess the effectiveness of modified Cangfu Daotan Decoction combined with metformin on polycystic ova-ry syndrome(PCOS)with obesity by Meta-analysis.Methods Data bases containing CBM,CNKI,WF,VIP,PubMed and Embase were searched to retrieve randomized controlled trials(RCTs)that MDCC combined with metformin(trial group)versus metformin a-lone in the treatment of PCOS.The search time was set from January 2000 to December 2021.Revman 5.4 software was used to con-duct Meta-analysis after data extraction and quality evaluation with Cochrane 5.1.0 bias risk evaluation tool and Jadad scale.Results Fourteen literatures meeting the requirements were included and they are in total of 980 cases of patients.Meta-analysis results sug-gested that the treatment group was superior to the control group in improving total response and ovulation rate,reducing BMI index,insulin resistance index,follicle-stimulating hormone,luteinizing hormone,testosterone and estradiol levels,with statistical signifi-cance.However,no statistically significant in prolactin.Conclusion Compared with using metformin alone,mofified Cangfu Daoton Decoction with metformin in the treatment of obese PCOS patients possessed better curative effect.
Professor Han Ming xiang is a master of traditional Chinese medicine.He has been working in Xinglin for 60 years.He has rich clinical experience and clear thinking,and has unique views on internal diseases of traditional Chinese medicine.He be-lieves that thyroid nodules and benign breast nodules belong to the category of"abdominal mass"in traditional Chinese medicine,its common pathogenesis is"liver dysfunction".Qi stagnation,blood stasis and phlegm turbidity are the main pathological products.Treatment can start with the theory of"liver governing",based on soothing the liver,taking into account the elimination of symptoms,resolving phlegm and promoting blood circulation.
Through the collation and study of the relevant literature and monographs,the external treatment of Zhuang medicine has many kinds and characteristics,and it has certain advantages in clinic,in the theory,clinical research has achieved good results,it is worth in the clinical and experimental further research and promotion.
Objective To establish the contamination method of aflatoxin B1,B2,G,and G2 in EQUI PENIS ET TESTIVULUS by immunoaffinity column clean-up and HPLC-FLD with post-column photochemical derivatization.Methods After extraction with 70％Methanol and purification by immunoaffinity columns,aflatoxin B1,B2,G1 and G2 in samples were anlyzed by HPLC-FLD with post-column photochemical derivatization.Results The linearity of Aflatoxin B,was at 0.0104-0.0520 ng(r=0.9999),Af-latoxin B2 was at 0.0038-0.0190 ng(r-0.9998),Aflatoxin G1 was at 0.0108-0.0540 ng(r=0.9998),Aflatoxin G2 was at 0.0038～0.0190 ng(r=0.9998),The average recoveries were within 89.68％-101.44％with RSD≤3.5％.Conclusion The a-bove method has demonstrated convenient operation,good repeatability,highsensitity and accuracy.This method is suitable for the determination of AF in Renshenguipi pills.
Objective To explore the effect of Yajie Yizai(Xin)Recipe on blood lipid,inflammation,oxidation factors,and the possible mechanism of anti AS in atherosclerosis model rats.Methods The AS model was established by intraperitoneal injection of VD3+high-fat feed,and was randomly divided into control group,model group,simvastatin group,and Yajie Yizai(Xin)recipe high-dose and low-dose groups.Detect the levels of TG,LDL-C,and HDL-C in serum of rats,use ELISA method to detect the activities of superoxide dismutase(SOD),catalase(CAT),glutathione peroxidase(GSH-PX)and the influence of malondialdehyde(MDA)content in serum of rats in each group,and detect the levels of IL-6 and TNF in serum-α Content.Results Compared with the model group,the high and low dose Yajie Yizai(Xin)groups showed a decrease in serum TG and rat LDL content,while the HDL content increased.The difference between the two groups was statistically significant(P＜0.01 or P＜0.05).Compared with the mod-el group,both high-dose and low-dose Yajie Yizai(Xin)groups were able to increase GSH-PX,SOD,CAT activity,and reduce MDA content,with statistical significance(P＜0.05 or P＜0.01);Compared with the model control group,the Yajie Yizai(Xin)high-dose group,Yajie Yizai(Xin)low-dose group,and simvastatin group had TNF-a、The content of IL-6 significantly de-creased,and the differences were statistically significant(P＜0.01 or P＜0.05).Conclusion Yajie Yizai(Xin)has a significant anti AS effect.The mechanism of action may be that it can reduce the lipid peroxidation damage of arterial endothelial cells,improve the inflammato-ry reaction,reduce the inflammatory reaction,and inhibit the atherosclerosis process by regulating the lipid metabolism of rat models.
