Two zinc-based metal-organic gels (MOGs) were synthesized via coordination-driven self-assembly of a methoxy-functionalized terpyridine ligand with Zn(II) ions in the presence of the amino acids L-alanine or L-proline, forming three-dimensional supramolecular networks. Both MOGs were characterized using spectroscopic, microscopic, thermal, and rheological techniques to establish their morphology and physicochemical stability. The gels exhibit photoluminescence that is modulated in the presence of anions (Cl−, NO₃−, F−, SCN−, I−, and Br−), enabling qualitative assessment of anion-responsive behaviour. Apparent optical band gaps estimated from Tauc's analysis suggest semiconducting-like optical transitions. The observed mechanical strength, reproducible optical response, and anion-dependent emission behaviour indicate that these MOGs are promising candidates for environmental sensing and flexible optoelectronic applications.
Platinum(IV) prodrugs can modulate stability, tissue distribution, reduction kinetics and release behaviour through axial-ligand design and have long been considered a feasible strategy for broadening the therapeutic window of platinum drugs. Tumour microenvironment (TME)-responsive designs offer further opportunities for selective activation. However, a responsive signal, increased total platinum accumulation or enhanced cytotoxicity does not, by itself, establish local activation at the lesion level. Focusing on three issues—local evidence for Pt species, release sequence and translational boundaries—this critical review re-examines enzyme-responsive, redox- and hypoxia-responsive, multi-responsive and exogenously triggered platinum(IV) systems from medicinal-chemistry and translational perspectives. We argue that the value of TME-responsive platinum(IV) prodrugs depends less on the number of triggers or the magnitude of endpoint efficacy than on whether exposure, activation, release and pharmacodynamic output can be connected into an interpretable and testable evidence chain. This evidence-calibration framework may aid mechanistic attribution, candidate selection and translational decision-making for related systems.
Persistent organic pollutants such as dyes, antibiotics, and pharmaceuticals are difficult to remove from water due to their chemical stability and low biodegradability. Semiconductor photocatalysis offers an effective approach to transform these pollutants through light-driven oxygen reduction reactions. Zirconium-based materials have attracted particular attention in this field. This has progressed from ZrO₂ to modified ZrO₂ and zirconium-based metal-organic frameworks (Zr-MOFs). Although ZrO₂ is chemically stable, its wide band gap limits the use of visible light. Zr-MOFs offer tunable porosity and surface chemistry, making them ideal platforms for coupling pollutant adsorption with photocatalytic processes. This review focuses on Zr-MOF-based photocatalysts and their composites for the transformation of organic pollutants in water systems. Particular attention to the interactions between material structure, adsorption, charge separation, and interfacial charge transfer. Remaining challenges in stability, recovery, process understanding, and practical wastewater treatment are also discussed.
In this work, a hydrogen-bonded supramolecular 3D Ni-based coordination polymer, {[Ni(H₂O)₆][Ni(H₂O)₄(btc)]0.4(H2O2)}ₙ (AF-25), was successfully synthesized via a template-assisted strategy at room temperature using 1,2,4,5-benzenetetracarboxylic acid as an oxygen donor ligand. Comprehensive characterization using elemental analysis, X-ray diffraction (SCXRD) analysis, FT-IR, PXRD, TGA, SEM, and EDX confirms the robust structural integrity of AF-25. It exhibits excellent iodine uptake in vapor, and organic phases, achieving a maximum adsorption capacity of 566 mg g−1 under dry conditions at 70 °C because of π-electron-rich aromatic rings and accessible oxygen donor sites. Under humid conditions, it retains a high iodine uptake capacity of 302 mg g−1 at 70 °C whereas in organic solvents it achieves 91–92% iodine removal efficiency. Motivated by free carboxylate groups, Ni-Coordination network was examined for metal capture in aqueous media and, among various metal salts, displayed superior selectivity and capture efficiency toward hard, highly polarizing Fe3+ ions in solution environments.
The hexacoordinated [Cu(DMPT)(H2O)2OClO3]ClO4.2H2O; 1, [Co(DMPT)(H2O)3](NO3)2.H2O; 2, and [Ni(DMPT)(NCS)2H2O]; 3 complexes were obtained by self-assembly of the corresponding related metal salts with 2,4-bis(morpholin-4-yl)-6-[(E)-2-[1-(pyridin-2-yl)ethylidene]hydrazin−1-yl] − 1,3,5-triazine ligand (DMPT). The structures of these complexes have been confirmed using FT-IR, elemental analysis, and single-crystal X-ray diffraction (SCXRD). Each complex contains one unit of the neutral tridentate NNN-chelate (DMPT) and three monodentate ligands. 1 exhibits Jahn-Teller distortion, showing a significantly elongated octahedral configuration around Cu(II). Hydrogen bonding plays a major role in the crystal packing of 1 and 2 via O‧‧‧H contacts (45.8 and 33.4%, respectively), while van der Waals interactions are predominant and significant in the packing of 3 via S‧‧‧H contacts (21.5%). The M-N and M-O bonds in all complexes exhibit partially covalent character, based on the atoms in molecule study. Cytotoxicity evaluation revealed that 1 exhibited potent anti-proliferative activity against HCT − 116 and A-549 carcinoma cells (IC50 = 9.58 ± 0.54 and 18.87 ± 1.13 μM, respectively), comparable to cis-platin. Antimicrobial examinations showed that 1 and 2 produced inhibition zones of 21–26 mm, comparable to those of gentamicin (24–26 mm) where the best action was found for 1 against B. subtilis (MIC = 156.25 μg/mL)).
