The journal retracts the article titled “Repurposing Diltiazem for Its Neuroprotective Anti-Dementia Role against Intra-Cerebroventricular Streptozotocin-Induced Sporadic Alzheimer’s Disease-Type Rat Model” [...]
The Journal retracts the article “Secukinumab and Black Garlic Downregulate OPG/RANK/RANKL Axis and Devitalize Myocardial Interstitial Fibrosis Induced by Sunitinib in Experimental Rats” [...]
The present study aimed to design, synthesize, and evaluate a new series of thieno[3,2-d]pyrimidin-4(3H)-one-based Schiff bases as potential antileishmanial agents against Leishmania major (L. major). A series of twenty thieno[3,2-d]pyrimidine Schiff base derivatives were synthesized and characterized using FTIR, NMR, and HRMS techniques. Their antipromastigote activities were evaluated in vitro against L. major, while cytotoxic effects were assessed on HUVECs to determine selectivity indices. The most active compound was further investigated using molecular docking against several L. major proteins. Among the tested compounds, compound 12, bearing a 2-hydroxy-5-bromophenyl moiety, exhibited the most potent activity against L. major promastigotes with an IC50 value of 13.7 µM, along with a favorable selectivity index (SI = 17.5), outperforming the reference drug miltefosine (IC50 = 31 µM and SI = 0.2). Docking studies demonstrated that compound 12 showed the strongest binding affinity toward phosphodiesterase B1, supported by a docking score of −9.042 kcal/mol and an MM-GBSA value of −67.21 kcal/mol. This study highlights thieno[3,2-d]pyrimidin-4(3H)-one as a promising scaffold in the context of in vitro antileishmanial screening and suggests the role of ortho-phenolic substitution in enhancing activity and selectivity. Compound 12 emerges as a promising lead, warranting further optimization and biological evaluation in future studies.
Capillary malformation–arteriovenous malformation syndrome is a rare spectrum of vascular anomalies characterized by capillary malformations and high-flow vascular malformations, caused by loss-of-function mutations in the RASA1 and/or EPHB4 genes. These mutations disrupt vascular differentiation and lead to complex malformations involving the brain, skin, and systemic vasculature. Since the first description in 2003, more than 200 cases have been reported, but intracranial arteriovenous shunts during the neonatal period remain extremely rare, as well as reports of the dual mutation RASA1 + EPHB4 or the immunological impact of the EPHB4 mutation. We report three cases of neonates presenting with early-onset high-flow shunts, each exhibiting a distinct genetic signature: CM-AVM1 (RASA1 mutation), CM-AVM2 (EPHB4 mutation), and dual variant (combined EPHB4 and RASA1 mutations). We analyzed and compared the clinical evolution, Doppler ultrasound trends, EEG, MRI and genetic data to highlight the distinct genotype–phenotype spectrum. Early multimodal hemodynamic evaluation of neonates with CM-AVM allows the identification and optimum management of life-threatening shunts at the earliest possible stage.
Background: This study aimed to compare the effects of unstable strength training (UST) and traditional strength training (TST) on lower-body stability in adolescent volleyball players in China. Methods: This stratified randomized controlled trial recruited 62 eligible athletes from Shandong Province. Participants were assigned to either the UST group or the TST group, and both groups completed a 10-week training program. Results: Multivariate analysis of variance (MANOVA) for within-group effects revealed statistically significant improvements in all dependent variables for both the UST and TST groups (p < 0.05), FMS [F = 35.112, p < 0.001, η2 = 0.377]; and balance ability differences, left-side score (LS) [F = 8.268, p < 0.001, η2 = 0.125], right-side score (RS) [F = 8.094, p < 0.001, η2 = 0.122]. Furthermore, after controlling for covariates, MANCOVA analysis for between-group effects still showed statistically significant differences between the UST and TST groups on all post-test dependent variables. These differences included: functional differences, FMS [F = 34.412, p < 0.001, η2 = 0.389]; LS [F = 8.079, p < 0.01, η2 = 0.130]; and RS [F = 8.532, p < 0.001, η2 = 0.136]. Conclusion: UST is more effective than TST in improving athletes’ lower-body stability performance. Future studies should explore the application of UST in other sports and examine its effects on parameters beyond functional movement and balance.
