( Obstet Gynecol . 2026 Mar 1;147(3):336-343. doi: 10.1097/AOG.0000000000006143) One of the most common complications of pregnancy is diabetes mellitus, with pregestational diabetes having a prevalence of 1-2% and gestational diabetes accounting for 86% of diabetes during pregnancy. The prevalence of diabetes continues to increase in patients of reproductive age, making the management of diabetes during pregnancy of vital importance to reduce adverse outcomes for both mothers and babies. Diabetes can result in diabetic ketoacidosis (DKA), which most commonly affects individuals with type 1 diabetes, though it can affect any person with diabetes regardless of type. Pregnancy-related DKA can occur at lower glucose levels and develop more quickly, and is associated with significant adverse outcomes for both mothers and babies. Euglycemic DKA occurs due to an imbalance between insulin and other hormones and can occur more frequently in pregnant individuals. It is expected that in the coming years, clinicians will more frequently encounter euglycemic DKA, and this article is a review of the physiology and current evidence surrounding the diagnosis and management of euglycemic DKA during pregnancy.
( Anesthesiology 2025 Oct 1;143(4):827–834. doi: 10.1097/ALN.0000000000005634) An important current issue in pediatric anesthesiology is the possible neurotoxic effects of anesthetic agents in early childhood; studies have demonstrated that exposure to these agents during critical brain development periods can cause nerve cell damage, disrupt brain connectivity, and lead to lasting issues with memory and learning. Though many studies on this topic have been published, the true effects of these agents are still largely unknown, necessitating further research. This study was designed to assess intelligence and behavioral assessment outcomes between sevoflurane alone and dexmedetomidine and remifentanil combined with sevoflurane during a single exposure.
( Anesth Analg 2026 Apr 1;142(4):653–663. doi: 10.1213/ANE.0000000000007718) A retrospective cohort study examined outcomes among patients undergoing major noncardiac surgery within a German hospital network, comparing 3 distinct care approaches: transfusion-free blood management (TFBM) for nontransfusable patients, patient blood management (PBM) for transfusable patients, and standard care without PBM. The primary goal was to evaluate differences between nontransfusable and transfusable patients, while the secondary objective was to compare PBM with no-PBM in transfusable individuals.
( Int J Obstet Anesth 2025 Aug:63:104693. doi:10.1016/j.ijoa.2025.104693) This prospective qualitative study explored how mothers experience a category 1 cesarean delivery (CD) performed under general anesthesia (GA) when their partner is present in the operating room. Category 1 CDs are conducted in situations involving an immediate threat to the life of the mother and/or infant and must meet a rapid decision-to-delivery interval of no more than 15 minutes in Denmark. To achieve this timeframe, GA is routinely used. Traditionally, partners were excluded from the operating room; however, since 2021, the study hospital has allowed partners to remain with the mother throughout the entire procedure. While prior research showed that partners strongly preferred being present, little was known about how mothers experienced this practice.
( Obstet Gynecol . 2026 Apr 1;147(4):479–490. doi: 10.1097/AOG.0000000000006084) The life expectancy of individuals with cystic fibrosis (CF) has increased drastically in the last few decades, meaning more individuals with CF are able to have children. Overall health in CF has also improved, meaning pregnancy has become more achievable and common. This is a direct reflection of the CF transmembrane conductance regulator (CFTR) therapy. This article is a review discussing considerations for reproductive health and the use of CF therapeutics in these patients during pregnancy in this population. It includes an overview of CF, genetics and inheritance involved in the condition, novel therapies, fertility, counseling, and the management of CF before and during pregnancy, as well as potential effects on developing fetuses and ongoing areas of research.
