This study develops a reproducible, place-adaptable framework of industries exposed to water security and implements an input–output approach to measure their regional economic significance. We apply this framework to the Greater Everglades region in South Florida, a 16-county area where historic ecosystem alteration and ongoing restoration efforts make water management central to regional prosperity. Our framework combines a theory-based approach with data-driven and literature-based protocol to validate and screen industries into the Clean Water Economy. Results show the Clean Water Economy accounts for approximately 27% of total output, 24% of value added, and 19% of labor income in the region. This framework provides an economic baseline for tracking water-economy trends, recognizing stakeholders beyond traditional water users, and guiding investment decisions in regional water management.
