In our research, we synthesized a novel series of quinoline–triazole hybrids rationally designed to improve antiproliferative activity against breast cancer (BC). The compounds were tested in vitro against MCF-7 and...
A new series of paracetamol-derived 4-hydroxyphenylamino-pyridine-3-carbonitrile hybrids (3a-o) was designed and synthesized in good yields (35.3-76.7%) through the reaction of N-(4-hydroxyphenyl)acetamide (1) with various arylidenemalononitriles (2) in the presence of...
Pharmaceutical process-related impurities are generally regarded as undesirable by-products, yet their structural diversity may provide an underexplored source of bioactive scaffolds for medicinal chemistry. Herein, we demonstrate an impurity-driven lead...
With the continuous increase in the aging population and the number of immunocompromised individuals, invasive fungal infections (IFIs) caused by Candida albicans have become increasingly severe, highlighting an urgent clinical...
Benzamides containing benzoxazole nuclei were synthesized using two complementary synthetic approaches and subsequently evaluated for their in vitro antiproliferative, antibacterial, and antioxidant activities. Several compounds exhibited pronounced antiproliferative activity across...
