• Bulge progenitors’ cells (BPC) are multipotent cells that fuel hair follicle cycling, sebaceous turnover, and epidermal repair. • BPC activation from quiescence is governed by niche-derived Wnt/β-catenin (anagen entry), BMP antagonism (licensing transit), and TGF-β/Smad (catagen enforcement). • Preclinical models demonstrate de novo folliculogenesis using BPC- dermal papilla cell recombinants in 3D scaffolds, with > 70
