Stoma outlet obstruction (SOO) is a notable complication following diverting loop ileostomy (DLI) for colorectal cancer. However, no definitive risk factors for SOO have been identified. This study aimed to determine the risk factors associated with SOO. This retrospective study included 167 consecutive patients who underwent elective colorectal cancer surgery with DLI at Chiba University Hospital between January 2010 and October 2024. We evaluated the patient, tumor, and surgical factors along with the computed tomography-based anatomical measurements. These included rectus abdominis muscle (RAM) thickness, subcutaneous adipose tissue (SAT) thickness, stoma penetration angles, penetration site through the RAM, and proximal limb orientation measurements. SOO occurred in 21 (12.6
Early predictive biomarkers for response to atezolizumab plus bevacizumab (Atez+Bev) in advanced hepatocellular carcinoma (HCC) remain unclear. We investigated the prognostic significance of early thyroid-stimulating hormone (TSH) dynamics and the aspartate aminotransferase-to-platelet ratio index (APRI) in patients receiving Atez+Bev. We retrospectively analyzed 32 patients with advanced HCC treated with Atez+Bev. TSH ratios after 1 and 2 treatment cycles were calculated relative to baseline. Cutoff values were determined using receiver operating characteristic analysis. Progression-free survival (PFS) was evaluated using Kaplan–Meier analysis and Cox proportional hazards models. Landmark analysis was performed to minimize immortal time bias. The objective response rate was 25
Multiple arterial coronary artery bypass grafting (CABG) has been associated with superior long-term outcomes compared with single arterial CABG. However, randomized trials comparing percutaneous coronary intervention (PCI) with CABG have largely evaluated single arterial grafting strategies, leaving evidence comparing multiple arterial CABG with PCI limited. This systematic review and meta-analysis was registered prospectively in PROSPERO (CRD42025106759). MEDLINE, Embase, and the Cochrane Central Register of Controlled Trials were searched for studies published from inception through September 30, 2025, that compared outcomes between multiple arterial CABG and PCI in patients with multivessel coronary artery disease. Study-level meta-analyses and reconstructed individual patient data (IPD) meta-analyses were performed. The primary outcome was all-cause mortality, and the secondary outcome was major adverse cardiovascular and cerebrovascular events (MACCE). Ten observational studies were included. Study-level meta-analysis showed higher all-cause mortality with PCI (hazard ratio [HR] 1.78, 95
To evaluate the visualization rates of the hypogastric and pelvic splanchnic nerves using magnetic resonance neurography (MRN) and to identify associated factors. This study included patients with rectal carcinoma who underwent preoperative MRN at our institution between December 2019 and September 2020. Two gastrointestinal surgeons evaluated the visibility of the hypogastric and pelvic splanchnic nerves on a per-nerve basis, with scores of “excellent” or “good” defined as successful visualization. The visualization rates of the hypogastric and pelvic splanchnic nerves were 21.6
Lower extremity arterial disease (LEAD) is a risk factor in patients undergoing coronary artery bypass grafting (CABG); however, the impact of chronic limb-threatening ischemia (CLTI), its most advanced stage, remains unclear. We evaluated early and long-term outcomes of CABG in CLTI. We retrospectively analyzed 334 consecutive patients who underwent isolated CABG between 2014 and 2024. Patients were stratified into three groups: CLTI (n = 22), non-CLTI LEAD (n = 41), and non-LEAD (n = 271). The primary endpoint was long-term survival; the secondary endpoints were 30-day mortality and major adverse cardiac and cerebrovascular events. The CLTI group had higher rates of diabetes mellitus (90.9
