目的 探讨手术协同5-氨基酮戊酸光动力疗法(ALA-PDT)治疗面部非黑色素瘤皮肤癌(NMSC)的效果,为临床提供参考.方法 按随机数字表法将 2020年12月至2022年12 月内蒙古科技大学包头医学院第一附属医院收治的 100例面部NMSC患者分为对照组(给予手术治疗)和观察组(在对照组的基础上联合ALA-PDT治疗),各 50例.比较两组患者的临床疗效、临床愈合情况和血清肿瘤因子水平.结果 观察组患者整体疗效优于对照组,总有效率高于对照组(P<0.05).两组患者伤口一期愈合率比较,差异无统计学意义(P>0.05);观察组患者创面愈合时间短于对照组(P<0.05);术后 3 周,两组患者皮损面积小于术前,且观察组小于对照组(P<0.05).术后 3 周,两组患者血清胚胎成形素(Nodal)、转录中介因子 1-γ(TIF1-γ)、转化生长因子-β1(TGF-β1)及白细胞介素-1β(IL-1β)水平均低于术前,且观察组低于对照组(P<0.05).结论 手术联合ALA-PDT治疗面部NMSC的效果显著,能有效促进创面愈合,降低相关血清肿瘤因子水平.

目的 探讨光动力疗法对中重度痤疮患者体内Toll样受体及皮脂腺分泌的影响.方法 收集18例中重度痤疮患者行光动力治疗,临床有效性通过对治疗前后痤疮皮损的严重程度、皮脂腺分泌进行评估.在第一次治疗前与最后一次治疗后行皮损病理取材,通过免疫组织化学来观察Toll样受体2(Toll-like receptor 2,TLR2)、Toll样受体4(Toll-like receptor 4,TLR4)和Fas的表达情况.结果 炎症性皮损治疗后显著减少(P＜0.01),皮脂油脂分泌在治疗后第2周显著减少(P＜0.05).治疗后TLR2与TLR4表达均明显减少.结论 光动力疗法对中重度痤疮的作用可能与TLR2和TLR4的表达减少有关.

Psoriasis, a common skin inflammatory disorder, is characterized by the aberrant growth and differentiation of keratinocytes. Ar-Turmerone, a main bioactive ingredient of Curcuma longa , has been found to alleviate skin inflammation in psoriasis-like mice. However, the effects and underlying mechanism of ar-turmerone on keratinocytes remain unknown. The effects of ar-turmerone alone or combined with recombinant human sonic hedgehog (rhShh) on cell proliferation, apoptosis, and inflammatory cytokine secretion were explored by MTT, flow cytometry analysis, and ELISA, respectively. The mRNA and protein levels of Shh, glioblastoma-1 (Gli1), and smoothened (SMO) were determined by RT-qPCR and western blot analysis, respectively. Results disclosed that ar-turmerone dose-dependently suppressed proliferation, facilitated apoptosis, and reduced TNF-α-mediated production of interleukin (IL)–1β, IL-6, and IL-8 in HaCaT cells. Ar-turmerone blocked Hedgehog pathway in HaCaT cells, as evidenced by the reduced expression of Shh, Gli1, and SMO. Moreover, activation of the Hedgehog pathway by rhShh abolished the effects of ar-turmerone on the proliferation, apoptosis, and TNF-α-mediated inflammatory cytokine expression in HaCaT cells. In conclusion, ar-turmerone suppressed cell proliferative ability and attenuated inflammatory cytokine expression by inactivating Hedgehog pathway in HaCaT cells, contributing to better understanding the potential anti-psoriasis effects of ar-turmerone on psoriasis.

Aristaless-like homeobox1 (ALX1), a member of the ALX family, is capable of mediating survival and development of mesenchyme-derived elements in vertebrates and its mutation will prevent the fusion of frontonasal and maxillary elements. Recently, ALX1 has been reported to be associated with cancer progression. However, the specific roles of ALX1 in melanoma remain unclear. In this study, we investigated the expression pattern and biological functions of ALX1 in melanoma. We found that ALX1 was highly expressed in melanoma tissues and cell lines. Knockdown of ALX1 suppressed the proliferation and invasion of melanoma cells. Furthermore, we showed that ALX1 knockdown reversed the epithelial-mesenchymal transition (EMT) process in melanoma cells, which might be attributed to inactivation of the Wnt/β-catenin pathway. Taken together, this study provided a new insight into the role of ALX1 as a therapeutic target for melanoma treatment.

Objective To indentify the cognitive status of Chinese patients to acne and the influencing factors to theirs' cognitive status,so as to provide solid evidences for the prevention and treatment of acne.Methods A self-designed questionnaire was made to conduct this survey of 16,156 acne patients,who seeked to the treatment in the dermatological departments from 112 hospitals in China.The survey consisted of several parts,including the general status of patients,the patients' cognition of occurrence,development and risk factors of acne,whether the first choice was seeking treatment at the hospital when the patients had acne and the condition of selection of skin care products.The factors were analyzed,which could impact the cognition of the patients' behavior of treatment,how did the patients' cognition to influence their medical behavior and skin care as well as the consistency of assessment of the severity of acne by doctors and patients themselves.Results The acne patients studied had the best knowledge of "acne is a skin disease","it not only occurs in the period of adolescence" and "the disease can be prevented and cured",which accordingly accounted for 80.65％,69.16％ and 65.49％ of the total patients respectively.However,the awareness of acne patients to heredity,high sugar and dairy products as risk factors for acne was insufficient,which accounted for 48.72％,42.40％ and 18.25％ of the total patients,respectively.Gender,age,educational level,occupation and health knowledge were the main factors affecting the cognitive level of patients;the survey also found that men,patient with educational level of junior high or even lower educational condition,occupation of labor workers or farmers and patients were lack of health education with poor knowledge of the genetics and dietary were risk factors for acne;patients with age over 36 years or with mild illness had poor knowledge of dietary risk factors for acne;the difference was statistically significant (P＜0.05).The analysis of the influence of cognitive status on medical treatment behavior and skin care showed that the better the cognition,the higher the probability of patients would choose medical treatment as the first choice as well as choosing functional skin care products;the difference was statistically significant (P＜0.05).The consistency of assessment of the severity of acne by doctors and patients was poor (Kappa value ＜0.4),and the assessment of severity of acne by patients was more serious than doctors' assessment.Conclusions Patient's cognitive status will affect their medical behavior and skin care,and there is also a phenomenon that patients have a more serious assessment of their acne condition.It is suggested that health education for acne patients should be strengthened in clinical medicine so as to improve their knowledge of acne as well as preventing from acne effectively.

Objective To assess the efficacy and safety of alpha hydroxyl acid combined with acne extrusion for close acne.Methods One hundred and thirty-three subjects mainly with close acne were randomly divided group A treated with ache extrusion alone and group B treated with alpha hydroxyl acid combined with acne extrusion.Both groups were treated once every 3 weeks,4 treatments per course.Results Mter two treatments,the effective and cure rates were similar between group A and B(effective rate:17.46％ vs.20.00％;cure rate:4.76％ vs.5.71％).But after four treatments,both effective and cure rates were significantly higher in group B than in group A(effective rate:65.71％ vs.46.03％,P ＜0.05;cure rate:42.86％ vs.23.81％,P ＜ 0.05).The effective rates were higher after 4 treatments than 2 treatments.High incidence of adverse reactions occurred following treatment with high concentration of alpha hydroxyl acid in group B,while localized pain developed on the extrusion sites in group A.Conclusion Treatments with alpha hydroxyl acid combined with acne extrusion are safe and effective for close acne.High concentration of alpha hydroxyl acid is more effective,but with a higher incidence of adverse reactions.

目的:探讨包头地区儿童特应性皮炎(AD)与肥胖的相关性,为儿童AD的治疗提供新的思路.方法:212例AD患儿,年龄0～9岁,对照组为随机选取的424例同期进行健康体检的同龄儿童.采用免疫印迹方法检测血清特异性IgE抗体水平;测量身高及体重,评估年龄段体重指数百分度;采用湿疹面积及严重度指数(EASI)评分评估皮损严重程度;采用条件逻辑归因分析评估AD与肥胖的相关性.结果:经调整多种潜在性干扰因素后,肥胖与AD(OR=4.1,95％CI:2.23～5.76,P＜0.01)及AD皮损严重程度(OR=2.15,95％CI:1.31～3.56,P＜0.01)均密切相关.结论:儿童AD的发生发展与肥胖密切相关;肥胖是儿童AD皮损加重的危险因素之一.

目的 观察不同浓度果酸换肤治疗的疗效与副作用,评估其安全性及治疗效果.方法 选取闭合性痤疮患者68例,利用果酸换肤术治疗,治疗后1周行粉刺挤压术.果酸治疗每3周1次,4次为1个疗程.结果 治疗1次后,有效率1.5％;治疗2次后,有效率7.4％;治疗3次后,有效率23.5％;治疗4次后,有效率38.2％.治疗2次和4次时的有效率进行比较,后者较前者明显增高,差异有统计学意义.结论 果酸换肤术可以有效的治疗闭合性痤疮,较高浓度的果酸可以增强治疗效果.

目的 分析临床常见的诱发药疹的致敏药物种类以及药疹的临床表现.方法 回顾性分析我院收治的药疹病人的临床资料,归纳诱发药疹的药物种类及临床表现.结果 临床常见的致敏药物为抗生素类,其次为解热镇痛类和抗痛风类,中成药类也有较多致敏病例.药疹类型主要为麻疹型或猩红热型药疹,其次为荨麻疹样皮疹和多形性红斑、固定型红斑.结论 临床上很多药物可诱发药疹的发生,对于好发药疹的抗生素类等药物服用时应严格遵守其禁忌症,尽量减少药疹的发生,一旦药疹发生应立刻停药就医.对于中药类等温和药物的致敏作用也不容忽视.

患者女,22岁.躯干、四肢出现皮疹1个月,水疱半个月.皮损组织病理示:表皮下水疱,伴有大量淋巴细胞、中性粒细胞浸润,真皮浅层血管及附件周围大量淋巴细胞、中性粒细胞浸润.大疱性类天疱疮自身抗体Bp180抗体检测(-).完善抗核抗体谱及直接免疫荧光检查,ANA:颗粒型(+),胞浆型1∶320;Sm:(+);SS-A(天然60kDa):(+);SS-A(重组Ro52kDa):(+).直接免疫荧光结果:IgA,IgM,C3基底膜荧光(+).诊断:大疱性系统性红斑狼疮.

目的 对53例老年人皮肤鳞状细胞癌的临床及病理特征进行综合分析,提高对本病的认识及诊治水平.方法 收集2008年6月至2013年10月经我院皮肤科诊断明确的53例皮肤鳞状细胞癌病例,就患者的性别、发病年龄、皮损部位、临床误诊及临床表现、病理特征进行回顾性分析.结果 53例皮肤鳞癌患者中,男性多于女性,且以中老年多见;好发部位为暴露部位,且在不同年龄间有统计学差异;肿瘤有无溃疡在不同临床分型中不存在显著并异;皮肤鳞状细胞癌与外伤等刺激相关;各临床类型中以结节隆起型最易误诊.结论 (1)鳞癌主要发生在中老年人,以60～79岁为发病高峰.(2)慢性长期阳光照射与皮肤鳞状细胞癌发生密切相关.(3)皮肤鳞癌常继发于烧伤、外伤性瘢痕、慢性溃疡等基础上.

目的 观察308nm准分子光治疗白癜风的临床疗效,评估其安全性.方法 选取内蒙古地区白癜风患者30例,皮疹位于颈、躯干、四肢的非关节、非肢端、非骨隆起部位,共63片,利用308nm准分子光治疗,1次/周,5次为一个疗程,共4个疗程.结果 治疗5次后,有效率和显效率为7.93％和0;治疗10次后,有效率和显效率为17.46％和4.76％;治疗15次后,有效率和显效率为33.33％和15.87％;治疗20次后,有效率和显效率为46.03％和23.81％.治疗10次和20次时的有效率、显效率进行比较,后者较前者明显增高,差异有统计学意义.结论 内蒙地区白癜风患者颈部、躯干、四肢的非关节、非肢端及非骨隆起部位的白斑,应用308nm准分子光治疗时,有效率及显效率偏低,色素恢复随疗程的延长而增加.

目的 探讨直接免疫荧光检查对自身免疫性大疱性皮肤病的诊断价值.方法 对26例自身免疫性大疱性皮肤病患者的皮损采用鼠抗人免疫球蛋白(IgG,IgM,IgA)及补体C3进行直接免疫荧光检查,对结果进行回顾性分析.结果 天疱疮15例和大疱性类天疱疮11例.天疱疮IgG沉积为100％;IgM和补体C3沉积较少,分别为20％及40％;IgA未见沉积.大疱性类天疱疮IgG和补体C3沉积分别为88％及70％;IgM罕见沉积,IgA未见沉积,免疫荧光具有特征性.结论 直接免疫荧光检查对自身免疫性大疱性皮肤病的诊断、鉴别诊断、预后判断具有重要的意义.

皮肤性病学是临床医学生必修的专业课程,其专业性强、涉及面广、临床运用多.随着经济的发展,皮肤性病学专业正由传统向现代皮肤性病学发展,因此在教学内容上有了很多的更新.但从医学生全局教学来看,皮肤性病学专业的学时并不多,要使医学生更好地掌握皮肤性病学知识,需要我们更多地探讨教学方法、更新教学观念、优化教学资源,寻求知识性、实用性、趣味性与科学性相结合的教学方法.

目的 探讨异维A酸治疗6种皮肤病临床疗效.方法 对我院2010年1月到2012年1月收治的中度痤疮、重度痤疮、掌跖角化症、脂溢性皮炎、寻常型银屑病、原发性皮肤淀粉样变患者共100例的临床资料进行回顾性分析.结果 中度痤疮、重度痤疮、掌跖角化症、脂溢性皮炎、寻常型银屑病、原发性皮肤淀粉样变采用异维A酸治疗,总有效率为91％.结论 异维A酸治疗中度痤疮、重度痤疮、掌跖角化症、脂溢性皮炎、寻常型银屑病、原发性皮肤淀粉样变疗效确切.

目的 观察308nm准分子光联合外用铜制剂治疗内蒙古地区稳定期白癜风的疗效.方法 选取稳定期白癜风患者60例,共129片,随机分成2组:A组单用308nm准分子光治疗;B组308nm准分子光联合外用铜制剂治疗.每周1次,10次一疗程,共2疗程,每次疗程结束后拍照、疗效评价,记录结果.结果 两组的有效率和显效率在20次之后呈现统计学差异,B组的疗效优于A组.结论 内蒙地区白癜风患者颈、躯干、四肢的非关节、非肢端及非骨隆起部位的白斑,应用308nm准分子光治疗时,有效率及显效率偏低,联合外用铜制剂后可提高疗效.

反常性痤疮为一种好发于顶浆分泌腺密集部位的特殊的化脓性炎症,临床表现为反复发作的痛性皮下结节、脓肿、溃疡、窦道及瘢痕生成,目前认为其发病与遗传、免疫、感染及吸烟等因素有关.

目的:观察308 nm准分子光联合外用复方补骨脂酊治疗内蒙古地区稳定期白癜风的疗效.方法:选取稳定期白癜风患者60例,共133片皮损.将其随机分成2组:A组单用308 nm准分子光治疗;B组给予308 nm准分子光联合复方补骨脂酊治疗.复方补骨脂酊治疗每日两次,光疗频率每周1次,10次一疗程,共2疗程,每次疗程结束后拍照、疗效评价,记录结果.结果:治疗10次后,A组的有效率和显效率分别为17.46％和4.76％,B组分别为20.00％和5.71％;治疗20次后,A组的有效率和显效率分别为46.03％和23.81％,B组分别为65.71％和42.86％.两组治疗10次后的有效率和显效率比较差异均无统计学意义(P＞0.05),治疗20次后的有效率和显效率均显著高于其治疗10次后(P＜0.05),B组治疗20次后的有效率和显效率均显著高于A组(P＜0.05).所有患者的皮损均未出现严重不良反应.结论:308 nm准分子光联合复方补骨脂酊外用可提高内蒙地区白癜风患者颈、躯干、四肢的非关节、非肢端及非骨隆起部位的白斑的疗效,且安全性较好.

探讨腹腔镜技术在腹部外科的应用及展望。通过探讨腹腔镜技术在腹部外科的应用，介绍腹腔镜微创技术的国内外发展现状及优越性，展望腹腔镜技术的美好未来。

目的探讨妊娠合并梅毒的早期诊疗方法及对其新生儿预后的影响.方法回顾性我院收治的35例妊娠合并梅毒患者的诊疗资料，对照组均未进行产前检查及孕期治疗，观察组均经产前检查，且孕期给予积极治疗，观察两组的产妇的妊娠结局及新生儿预后的不同.结果观察组足月产率94.74%，显著高于对照组25.00%(P<0.01)，而先天梅毒患儿率5.26%，显著低于对照组37.50%(P<0.05)，两组比较差异显著具有可比性.结论妊娠合并梅毒患者应尽早诊断，并给予有效的抗梅毒治疗，可降低先天梅毒患儿的发生率，提高优生优育生平.