Predicting the folded structures of RNA molecules poses greater challenges than proteins, but steady progress continues.

For Nature Methods’ 20th anniversary, our current and past editors reminisce about their favorite papers, initiatives and projects at the journal.

Emerging algorithms are extracting information about macromolecular motions from cryo-EM data.

simple ‘binder/tag’ approach allows tracking of individual protein conformation changes in live cells.

combination of heat denaturation and mass spectrometry is applied to monitor protein-complex dynamics in the cell.