Safety concerns surrounding skin-lightening agents have intensified following chemical leukoderma linked to rhododendrol. Here, we performed an in vitro safety and hazard profiling comparison of raspberry ketone (RK) and a total anthraquinone fraction from Fallopia multiflora var. cillinerve (Polygonum cillinerve) using an immortalized keratinocyte-melanocyte co-culture model (human HaCaT keratinocytes and murine B10.BR melanocytes, 3:1). Rhododendrol and arbutin were included as contextual references. Following viability-guided range finding, cells were exposed for 48 h and evaluated for melanocyte stress and injury, including ROS generation, UPR/ER-stress activation (PERK/eIF2α-ATF4-associated readouts: ATF4, Hmox1, GADD45a; and IRE1 phosphorylation), IL-8-related chemokine output (CXCL1/KC, a murine functional homolog of IL-8), cell-cycle perturbation, and Caspase-3-associated apoptosis. In parallel, targeted LC-MS metabolomics was performed to resolve pathway-level perturbations. High-dose RK elicited a rhododendrol-like in vitro stress/toxicity signature, characterized by elevated ROS, robust UPR engagement, inflammatory chemokine induction, cell-cycle dysregulation, and pro-apoptotic responses; under viability-adjusted conditions, these effects remained more evident than with arbutin. Metabolomics revealed convergent disturbances between RK and rhododendrol, highlighting purine metabolism as a prominent perturbed pathway and suggesting purine-related metabolites as candidate indicators associated with leukoderma-relevant cellular stress in vitro. In contrast, the anthraquinone fraction did not trigger oxidative or ER stress within the tested range and exhibited a more favorable in vitro safety profile, including reduced ROS.

Insomnia, as one of the most common sleep problems, seriously affects the normal life and work of individuals. Aromatherapy is regarded as a promising alternative medicine for improving sleep quality. Based on network pharmacology and data mining, this study screened natural raw materials for improving insomnia. Then, we developed an aromatherapy product informed by the screening results and investigated its mechanism for improving insomnia through network pharmacology. Five core insomnia targets were identified through literature. 1600 candidate compounds and 1757 candidate herbs related to the target were matched using HERB and TCMSP databases. By comparing with the Catalogue of Used Cosmetic Materials (2021 edition), 597 kinds of usable candidate materials were selected, including 85 raw materials related to target MTNR1A, 86 raw materials related to target MTNR1B, 120 raw materials related to target HTR1A, 7 raw materials related to target GABRB2, and 582 raw materials related to target GABRA1. Then based on the screening results, we selected sandalwood, lime, angelica sinensis, yilan, sage and lavender to design Pinghe Sleep Aromatherapy Product to improve insomnia. Network pharmacological analysis revealed that the main ingredients of the Pinghe Sleep Aromatherapy Product are beta-sitosterol, stigmasterol, isorhamnetin, luteolin, tanshinone IIA, D-limonene, and linalool. It exerts improvement effects by influencing targets such as IL6, TNF, AKT1, CASP3, TP53, and VEGFA, regulating signaling pathways such as AGE-RAGE, neuroactive ligand-receptor interactions, the HIF-1 signaling pathway, and the calcium signaling pathway. This study provides an idea of raw material screening and product development, which can save product development cost and shorten product development cycle by using network pharmacology and data mining.

Pentosidine, a key fluorescent advanced glycation end-product (AGE), serves as an indicator for glycation levels in medical and food research. Given the low cutaneous pentosidine levels and collection challenges, developing a non-invasive quantification method is essential. This study established a quantitative method for detecting pentosidine in facial skin using adhesive tape sampling coupled with LC-MS/MS analysis. The methodology was strategically optimized for enhanced sensitivity and stability, focusing on chromatographic conditions, mass spectrometric conditions, limit of detection (LOD), limit of quantification (LOQ), precision, and recovery rate were optimized. The established LC-MS/MS program had a duration of 2.2 min, with pentosidine eluting at 0.690 min. The method showed high sensitivity (LOD: 0.027 ng/mL; LOQ: 0.081 ng/mL), good recovery (83-109 %), and precision (CV: 2.46-7.42 %). demonstrating good accuracy. The pentosidine concentrations in the skin of the 10 subjects ranged from 0.3 to 1 ng/mL. These results demonstrate that adhesive tape sampling coupled with LC-MS/MS enables quantitative detection of pentosidine in skin. However, the detection results for the 10 subjects were close to the LOQ. Further optimizations can be made in the adhesive tape method to provide a basis for the development and efficacy evaluation of anti-glycation products in the future.

Hair loss is one of the skin conditions that can affect people’s mental health. Plant raw material extracts are of great interest due to their safety. In this study, we utilize reverse network pharmacology to screen for key targets of the Wnt/β-catenin signaling pathway and the TGFβ/BMP signaling pathway, as well as key differential lipids, for plant raw materials selection. The aim is to identify plant raw materials that may have anti-hair loss properties and to validate these findings through cell experiments. Licorice, salvia miltiorrhiza, mulberry leaf, ephedra and curcumae radix were found that may possess anti-hair loss effects. Licorice water extract (LWE), salvia miltiorrhiza water extract (SMWE), mulberry leaf water extract (MLWE), ephedra water extract (EWE) and curcumae radix water extract (CRWE) did not exhibit cytotoxicity on human dermal papilla cells (HDPCs). Through ALP staining, it was found that the expression of ALP in HDPCs treated with LWE, SMWE, MLWE, EWE and CRWE was enhanced. In addition, LWE, SMWE, MLWE, EWE and CRWE have reduced the expression of hair growth inhibitory factor TGF-β1 and inflammatory factor IL-6. Additionally, various water extracts can enhance the secretion of VEGF, with high concentrations of SMWE, EWE and CRWE exhibiting better efficacy. Furthermore, β-catenin, a key factor of the Wnt/β-catenin signaling pathway, was enhanced by LWE, SMWE, MLWE, EWE and CRWE treatment in cultured HDPCs. In conclusion, all five plant raw materials showed some anti-hair loss potential, providing theoretical support for their application in anti-hair loss products.

Sensitive scalp (SSC) is a common but often overlooked dermatological state, characterized by subjective symptoms such as pruritus, tingling, tightness, pain, or burning sensations. Primary SSC typically occurs in the absence of visible clinical inflammation. Numerous studies have suggested that the onset of SSC may be influenced by a variety of intrinsic and extrinsic factors, including physical (ultraviolet radiation, changes in temperature and humidity), chemical (cosmetic ingredients, environmental pollutants), and psychological factors (emotional stress). This article provides a narrative review of the current research on SSC, drawing on literature published between 1963 and 2024 in PubMed, Elsevier, and Web of Science databases. We summarize its hallmark symptoms, available evaluation methods, potential mechanisms, and contributing factors and propose corresponding scalp care recommendations. This review aims to offer theoretical insights into the pathogenesis of SSC and to support the development of effective protective strategies.

Purpose: To explore sensitive skin facial physiological parameters and lipid differences caused by skin aging. Methods: Female volunteers with sensitive skin were enrolled into the S1 group (22-28 years old) and the S2 group (29-35 years old). Skin surface lipid samples and physiological parameters were collected by non-invasive methods. Ultra-performance liquid chromatography quadrupole time-of-flight mass spectrometry (UPLC-Q-TOF-MS) techniques and partial least squares-discriminant analysis (PLS) were used to identify differential lipids. Results: Significant differences in skin elasticity, b* value and ITA was observed between S1 and S2 groups (p<0.05). In lipid profiling analysis, the two groups displayed a good degree of separation. There were five VIP lipids with significant differences between the two groups, including PA(20:0/22:2(13Z,16Z)) and Cer(d18:0/24:0). Lipids showed a significantly correlation with skin elasticity and ITA value (p<0.05). According to ROC analysis, the AUC values of PG(20:0/22:1 (11Z)) and Cer(d18:0/24:0) are greater than 0.7. The results showed that the prediction performance of these two lipids was better and more representative than other lipids. Conclusion: Compared with S1 group, the facial barrier function of the volunteers in S2 group did not change significantly, indicating that the effect of sensitive skin on the skin was stronger than the change of age on the skin barrier function in a certain period of time. Significant changes in elasticity, radiance and differential lipids involved in inflammation indicate that the volunteers in S2 group had exhibited a trend of early aging along with inflammatory aging.

Background: Sapindus mukorossi Gaertn is a deciduous tree with saponins as the main active ingredients and has been utilized in medicine and cosmetic industries. Currently, the investigations of S. mukorossi mainly focus on the pericarp and seed kernel parts, while other parts are yet to be studied and developed. This study aimed to investigate the anti-acne potential of S. mukorossi flower water extract (SMFW) by in vitro experiments. Methods and Results: The DPPH, ABTS, superoxide anion radical scavenging assay, and FRAP assay revealed the strong antioxidant activities of SMFW. The antibacterial activity of SMFW against Cutibacterium acnes has been evaluated with an inhibition diameter of 14.08 ± 0.63 mm. Furthermore, SMFW significantly inhibited the secretion of pro-inflammatory cytokines (TNF-α, IL-6, and IL-β) in lipopolysaccharide (LPS)-stimulated THP-1 macrophages. Transcriptome analysis showed that SMFW treatment reversed 448 LPS-upregulated DEGs and 349 LPS-downregulated DEGs, and KEGG enrichment analysis indicated that SMFW might exert its anti-inflammatory effect via NOD-like receptor and JAK-STAT signaling pathways. Conclusions: SMFW exhibited antioxidant, antibacterial, and anti-inflammatory properties in in vitro experiments. RNA-seq analysis indicated that SMFW may alleviate inflammation by regulating the NOD-like receptor and JAK-STAT signaling pathways. In summary, SMFW has shown potential for anti-acne efficacy and can be used as a natural raw material in cosmetics.

Type 2 diabetes is usually accompanied by premature grey hair. In this study, we analysed differences in the lipid composition of black and white hair follicles between women with type 2 diabetes and healthy populations, using lipidomic methods. We examined the correlation between the lipid composition of female grey hair follicles and type 2 diabetes mellitus, and we screened for potential grey-hair-delaying ingredients using network pharmacology. Forty-one female volunteers with type 2 diabetes (diabetes, D) and thirty-five healthy volunteers (healthy, H) aged 55-65 years were recruited. Hair roots, including the follicular portion, were collected from grey hair (D-W for diabetic volunteers and H-W for healthy volunteers) and black hair (D-B for diabetic volunteers and H-B for healthy volunteer). Lipids were extracted separately and analysed using UPLC-QTOF-MS (Ultra-Performance Liquid Chromatography-Tandem Time-of-Flight Mass Spectrometry), combined with an OPLS-DA (Orthogonal Partial Least Squares Discriminant Analysis) model to identify different lipids among different groups under VIP conditions (VIP > 1, p < 0.05, and fold change ≥ 2). Further screening was performed using the ROC (receiver operating characteristic) curve method, selecting lipids with an AUC (area under the curve) value greater than 0.8 and specificity plus sensitivity greater than 1.6. Finally, bioinformatics and reverse network pharmacology were used to screen relevant targets, ingredients, and herbs to find suitable raw materials with anti-grey-hair effects. We found the following: (1) Ten significant differential lipids were identified under VIP conditions in the D-W and D-B groups, and five potential differential lipids (1-O-alpha-D-glucopyranosyl-1,2-eicosandiol, emmotin A, odyssic acid, PI-Cer(t18:0/26:0(2OH)), and NAPE(18:1(9Z)/16:1(9Z)/18:0)) were further screened using ROC analysis. The levels of all five lipids were significantly higher in D-W than in D-B, and these elevated levels may have been related to the production of grey hair in diabetic patients. (2) Thirteen significantly different lipids were screened under VIP conditions in the H-W and H-B groups, and five potential differential lipids were screened via ROC analysis (PS(O-16:0/13:0), PA(12:0/16:1(9Z)), PS(13:0/20:3(8Z,11Z,14Z)), GlcCer(d18:1/24:1(15Z)), and PS(O-20:0/17:2(9Z,12Z))). The levels of all five lipids were significantly higher in H-B than in H-W, and we hypothesised that their reduced levels were associated with the production of grey hair in the healthy population. (3) Twelve significantly different lipids were screened under VIP conditions in the D-W and H-W groups, and two potential differential lipids were screened via ROC analysis (fucoxanthinol 3-heptadecanoate 3'-myristate and 2-(3-hydroxyphytanyl)-3-phytanyl-sn-glycerol). The contents of both lipids were significantly higher in H-W than in D-W, and there were differences in the lipid composition of grey hair in the D and H populations. (4) Important ingredients with possible therapeutic effects were obtained through lipid-matched target screening: resveratrol, calycosin, epigallocatechin 3-gallate, and herbs such as the fruit of the glossy privet, etc. In summary, the production of grey hair in the D and H populations may be affected by different lipids. The lipid components emmotin A and fucoxanthinol 3-heptadecanoate 3'-myristate were significantly higher in the D and H populations than in the same groups (D-B, H-B), and these are pregnenolone lipids (PRs). We hypothesised that PRs can influence the production of grey hair in both populations. The screening of important differential lipids may serve to provide diagnostic loci or therapeutic targets, while matching ingredients and herbs may provide a basis and direction for the subsequent development of anti-grey-hair ingredients.

Background: UPLC-Q-TOF-MS (Ultra-Performance Liquid Chromatography–Quadrupole Time-of-Flight Mass Spectrometry) is a high-precision, high-density technology for lipid analysis. Sensitive skin is a sub-stable condition, and it has been reported that the population of sensitive skin in China is predominantly female. Meanwhile, women with sensitive skin have different physiological parameters as well as lipid compositions at different ages. The Yellow Emperor’s Classic of Internal Medicine states that the number of women’s life cycles is seven, that major changes are manifested every 7 years, and that aging begins at age 35. At present, the correlation between facial lipid composition and aging indicators of sensitive skin in women aged 36–42 and 43–49 years has not been reported. Objective: This study reveals the relationship between key lipid composition of the facial skin and the aging of sensitive skin in women aged 36–42 and 43–49 years. Methods: We used UPLC-Q-TOF-MS technology to study the changes in lipid composition in the sensitive skin of woman aged 36–42 and 43–49 years, using a multi-probe adapter system with different types of skin-testing probes to test physiological parameters. Three types of multivariate data—questionnaires, physiological indicators, and lipid composition—were used together to assess differences in aging in a population of women with sensitive skin at different ages. Results: 1. In the questionnaire part, the T1 group was more susceptible to sunburn and the T2 group was more susceptible to tanning. 2. In the physiological index part, the aging characteristics of facial skin in the T2 group were obvious, with the b-value, as well as the brown area size, being significantly higher than the T1 group, while the TWEL, sebum, R2 value, ITA value, pore count, and concentration of the red area were significantly lower than the T1 group. 3. In the lipid part, the total facial lipid content was higher in the T2 group, with a significantly higher GP lipid, and the 47 VIP lipids obtained were analyzed by ROC curves, narrowing down to six lipids, PS(2-OMe-21:0/0:0), PS(O-18:0/20:5 (5Z,8Z,11Z,14Z,17Z)), PA(O-16:0/20:5 (5Z,8Z,11Z,14Z,17Z)), PS (P-16:0/12:0, PA (O-16:0/22:2 (13Z,16Z)), and PC (19:3 (10Z,13Z,16Z)/0:0)), and all six lipids were higher in the T2 group. 4. In Spearman correlation analysis, PS(O-18:0/20:5(5Z,8Z,11Z,14Z,17Z)), PS(P-16:0/12:0), PS(2-OMe-21:0/0:0), PA(O-16:0/20:5(5Z,8Z,11Z,14Z,17Z)), and PC(19:3( 10Z,13Z,16Z)/0:0), which are five lipids and skin aging indicators (TWEL, sebum, ITA value, b-value, pore count, concentration of red area, and brown area size) were significantly correlated. Conclusions: Through correlation analysis, it was found that changes in the composition of skin surface lipids (SSLs) in both age groups have an important influence on facial physiological indicators (aging manifestations) and played an important role in furthering the understanding of sensitive skin aging. Therefore, these lipid components also provide theoretical support for the development of cosmetic ingredients that slow down the aging of sensitive skin.

Advanced glycation end products (AGEs) formed via glycation reactions negatively impact skin health by diminishing barrier function and elasticity and causing dullness. This study systematically evaluated the inhibitory and degradative capabilities of 24 cosmetic ingredients against AGEs using BSA-glucose and ELISA-based screening systems. We identified 21 ingredients that inhibit fluorescent AGEs, 22 that degrade AGEs-collagen crosslinks, and 19 with both properties. Further investigation of six key ingredients, including freeze-dried Rosa rugosa powder (Rosa rugosa cv. Plena) and freeze-dried Camellia sinensis flower powder (Camellia sinensis (L.) O. Kuntze), revealed their notable ability to degrade AGEs monomers and dimers. Freeze-dried Rosa rugosa powder achieved a 19% inhibition rate in an MGO-induced HDFs glycation model. Our findings provide valuable insights for selecting anti-glycation agents and developing effective anti-glycation products.

Purpose: According to the life rhythm derived from the ancient Chinese medicine book Huangdi Neijing, female growth and development culminates between the age of 22-28, with strong muscles, bones and vigorous hair. To investigate the characteristics of facial lipid profile in oily skin of female at different developmental stages classified based on seven-year rhythm, and to provide the mechanistic insight into the aging theory of Huangdi Neijing.Methods: The facial lipid composition of two groups of healthy women with oily skin (O1 group: age of 22-28; O2 group: age of 29-35) was analyzed by ultra-performance liquid chromatography-quadrupole tandem time-of-flight mass spectrometry (UPLC-QTOF-MS). Differential lipids between O1 and O2 groups were identified using an orthogonal partial least squares discriminant analysis (OPLS-DA) model.Results: No significant difference in skin barrier function was found between the O1 and O2 groups. In contrast, skin elasticity and skin radiance displayed significant changes, with the O2 group showing decreased skin elasticity and dull skin, which is consistent with the description in Huangdi Neijing. In terms of lipid profile, among eight lipid main classes, seven lipid classes [FA], [GL], [GP], [PK], [PR], [SP] and [ST] showed significantly higher relative levels in the O2 group (p<0.05). Among the differential lipid species, myriocin, erucamide, phosphatidylserine, flavonoid compounds, and sphinganine were significantly and negatively correlated with skin elasticity (R2) and skin radiance (ITA) (p<0.05).Conclusion: The seven lipid species identified are important for targeting markers of skin aging and developing cosmetics that maintain skin elasticity and color.

BackgroundThe skin condition of women is different at different ages, and skin surface lipids are also different. According to the "7-7 theory" of the Huangdi Neijing, the physiological condition of women changes significantly every 7 years, and women aged 22-28 are in the "4-7" stage as mentioned in the "7-7 theory" of the Huangdi Neijing. Women's skin is in different states at different ages and produces different lipids.ObjectivesTo explore the key lipids that contribute to skin differences between women aged 22-28 and 29-35 years, and to explore the relationship with physiological parameters and daily routine.MethodsDifferential lipids were detected and screened between 22-28 year old (group D1) and 29-35 year old (group D2) dry-skinned women using UPLC-Q-TOF-MS and correlated between the two groups with questionnaires and physiological parameters based on basic information, lifestyle habits, work situation, and emotional stress.ResultsThe results showed that all of the eight major classes of lipids had the highest expression in the D2 group, with the largest differences in glycerophospholipids, glycerol esters, and fatty acids. The BMI value of D2 group was higher than that of D1 group, the skin elasticity index (R2) and brightness index (L, a, ITA values) were lower than that of D1 group, and Cer (d18:0/16:0) was positively correlated with the R2, L, a, and ITA, and LMSP01080056 (N,N-dimethyl-Safingol) was positively correlated with the b-value, the LMSPGP03020013, LMSPGP03020014, LMSP03020024 were significantly negatively correlated with R2.ConclusionsCer(d18:0/16:0) is a neurosphingol that inhibits elastase expression. N,N-dimethyl-Safingol readily undergoes oxidation to form yellow-brown solids. The macromolecular structure and excessive carbonyl structure of [LMGP0302] are susceptible to cross-linking and carbonyl stress reactions, which accelerate skin aging and reduce skin elasticity, and thus, they may be key lipids contributing to skin differences between the two age groups.

This review systematically summarizes research progress in the evaluation of the effectiveness and safety of the transdermal absorption of cosmetics, focusing on the classification, applicability, and relevant regulations of different evaluation methods. Transdermal absorption refers to the process in which active ingredients enter the epidermis, dermis, and other parts of the skin through the skin barrier and exert their effects. The article first classifies the in vitro and in vivo evaluation methods of transdermal absorption. It also provides a detailed overview of the regulations and standards for in vitro transdermal absorption, compares the standards of different institutions, and highlights the diffusion cell method, developed by scientists at Procter & Gamble, which is the mainstream method for in vitro testing. In addition, the paper summarizes the utilization of modern testing techniques such as high-throughput screening technology, mass spectrometry imaging, Raman spectroscopy, and confocal microscopy in the study of transdermal absorption and introduces the working principles of various instruments and their specific application cases in transdermal absorption studies.

OBJECTIVE:To elucidate the anti-ageing mechanism of the combination of eight ingredients on the skin from a multidimensional view of the skin. METHODS:The target pathway mechanisms of composition to delay skin ageing were investigated by a network pharmacology approach and experimentally validated at three levels: epidermal, dermal, and tissue. RESULTS:We identified 24 statistically significant skin ageing-related pathways, encompassing crucial processes such as epidermal barrier repair, dermal collagen and elastin production, inhibition of reactive oxygen species (ROS), as well as modulation of acetylcholine and acetylcholine receptor binding. Furthermore, our in vitro experimental findings exhibited the following outcomes: the composition promotes fibroblast proliferation and the expression of barrier-related genes in the epidermis; it also stimulated the expression of collagen I, collagen III, and elastic fibre while inhibiting ROS and β-Gal levels in HDF cells within the dermis. Additionally, Spilanthol in the Acmella oleracea extract contained in the composition demonstrated neuro-relaxing activity in Zebrafish embryo, suggesting its potential as an anti-wrinkle ingredient at the hypodermis level. CONCLUSIONS:In vitro experiments validated the anti-ageing mechanism of composition at multiple skin levels. This framework can be extended to unravel the functional mechanisms of other clinically validated compositions, including traditional folk recipes utilized in cosmeceuticals.

Preservatives are essential components in cosmetic products, but their safety issues have attracted widespread attention. There is an urgent need for safe and effective alternatives. Antimicrobial peptides (AMPs) are part of the innate immune system and have potent antimicrobial properties. Using machine learning-assisted rational design, we obtained a novel antibacterial peptide, IK-16-1, with significant antibacterial activity and maintaining safety based on β-defensins. IK-16-1 has broad-spectrum antimicrobial properties against Escherichia coli, Staphylococcus aureus, Pseudomonas aeruginosa, and Candida albicans, and has no haemolytic activity. The use of IK-16-1 holds promise in the cosmetics industry, since it can serve as a preservative synergist to reduce the amount of other preservatives in cosmetics. This study verified the feasibility of combining computational design with artificial intelligence prediction to design AMPs, achieving rapid screening and reducing development costs.

Skin aging refers to a degenerative process that can be affected and regulated by intrinsic and extrinsic factors. The mesenchymal stem cell secretome covers a considerable number of regenerative molecules with anti-aging effects in a wide variety of circumstances. However, it is complex, time-consuming, and costly to identify specific compounds from thousands of natural molecules using conventional methods. With the development of computational biology and machine learning, an efficient workflow was generated to identify novel peptides with anti-aging and skin restoration potential. One of the candidate peptides was discovered and subsequently truncated to a novel peptide named EQ-9, with promising anti-aging effects for topical applications at a concentration of 10 ppm validated by experimental validation. The above-described paradigm is expected to be further applied to the virtual screening of novel peptide molecules targeting specific biological functions from a wide variety of natural resources.

Regenerative medicine and anti-aging research have made great strides at the molecular and cellular levels in dermatology and the medical aesthetic field, targeting potential treatments with skin therapeutic and intervention pathways, which make it possible to develop effective skin regeneration and repair ingredients. With the rapid development of computational biology, bioinformatics as well as artificial intelligence (A.I.), the development of new ingredients for regenerative medicine has been greatly accelerated, and the success rate has been improved. Some application cases have appeared in topical skin regeneration and repair scenarios. This review will briefly introduce the application of bioactive peptides in skin repair and anti-aging as emerging ingredients in cosmeceutics and emphasize how A.I. based computational biology technology may accelerate the development of innovative peptide molecules and ultimately translate them into potential skin regenerative and anti-aging scenarios. Typically, two research routines have been summarized and current limitations as well as directions were discussed for border applications in future research.

网络药理学的出现是当前人工智能和大数据时代发展的结果,对医药领域疾病的治疗和新药的研发起着十分重要的作用,但未有关于网络药理学在化妆品领域中的相关应用研究.本文从药理学及中医药研究、复杂性疾病揭示、药物创制等几个方面回顾和梳理了网络药理学应用研究的发展现状,并对未来网络药理学在化妆品植物功效原料的选择、化妆品功效性评价、化妆品安全性评价三方面提出了应用设想.

通过监测2021-2022近1年间623 866条学生群体护肤相关网络舆情,分析了不同阶段学生人群护肤需求现状及未来发展趋势.结果表明,学生人群2021年舆情声量较2020年环比增加123%,呈现上升趋势,高中与大学时期护肤需求存在差异.高中时期,针对问题护肤和精简护肤为主流护肤认知,保湿、祛痘和控油为排名前3的功效需求.品类及品牌选择上,洁面、乳液、防晒位列前3,国产品牌占比高达62.5%;大学阶段学生人群护肤理念多元,但"平价护肤"仍以22.6%位列第1,对保湿、祛痘、祛斑美白、修复等功效均有所追求.在护肤品类中,面膜需求显著增加,以16.1%的占比仅次水乳位列第2,大牌热门单品及国产护肤品是该人群品牌选择趋势.以上结果有利于进一步了解学生人群护肤需求趋势,对产品市场定位有现实性的应用借鉴意义和经济价值.

Journal of the European Academy of Dermatology and VenereologyEarly View LETTER TO THE EDITOR Study on hair root lipids of female androgenetic alopecia based on UPLC-Q-TOF/MS results Xiao-qian Yu, Xiao-qian Yu orcid.org/0000-0001-5978-9227 Key Laboratory Cosmetics China National Light Industry, College of Chemistry and Materials Engineering, Beijing Technology and Business University, Beijing, China Beijing Key Lab of Plant Resources Research and Development, Beijing Technology and Business University, Beijing, ChinaSearch for more papers by this authorCong-fen He, Corresponding Author Cong-fen He [email protected] Key Laboratory Cosmetics China National Light Industry, College of Chemistry and Materials Engineering, Beijing Technology and Business University, Beijing, China Beijing Key Lab of Plant Resources Research and Development, Beijing Technology and Business University, Beijing, China Correspondence Cong-fen He, Key Laboratory Cosmetics China National Light Industry, College of Chemistry and Materials Engineering, Beijing Technology and Business University, Beijing, China. Email: [email protected] Yan Tian, Beijing Key Lab of Plant Resources Research and Development, Beijing Technology and Business University, Beijing, China. Email: [email protected]Search for more papers by this authorYan Tian, Corresponding Author Yan Tian [email protected] Department of Dermatology, Air Force Medical Center, PLA, Beijing, China Correspondence Cong-fen He, Key Laboratory Cosmetics China National Light Industry, College of Chemistry and Materials Engineering, Beijing Technology and Business University, Beijing, China. Email: [email protected] Yan Tian, Beijing Key Lab of Plant Resources Research and Development, Beijing Technology and Business University, Beijing, China. Email: [email protected]Search for more papers by this author Xiao-qian Yu, Xiao-qian Yu orcid.org/0000-0001-5978-9227 Key Laboratory Cosmetics China National Light Industry, College of Chemistry and Materials Engineering, Beijing Technology and Business University, Beijing, China Beijing Key Lab of Plant Resources Research and Development, Beijing Technology and Business University, Beijing, ChinaSearch for more papers by this authorCong-fen He, Corresponding Author Cong-fen He [email protected] Key Laboratory Cosmetics China National Light Industry, College of Chemistry and Materials Engineering, Beijing Technology and Business University, Beijing, China Beijing Key Lab of Plant Resources Research and Development, Beijing Technology and Business University, Beijing, China Correspondence Cong-fen He, Key Laboratory Cosmetics China National Light Industry, College of Chemistry and Materials Engineering, Beijing Technology and Business University, Beijing, China. Email: [email protected] Yan Tian, Beijing Key Lab of Plant Resources Research and Development, Beijing Technology and Business University, Beijing, China. Email: [email protected]Search for more papers by this authorYan Tian, Corresponding Author Yan Tian [email protected] Department of Dermatology, Air Force Medical Center, PLA, Beijing, China Correspondence Cong-fen He, Key Laboratory Cosmetics China National Light Industry, College of Chemistry and Materials Engineering, Beijing Technology and Business University, Beijing, China. Email: [email protected] Yan Tian, Beijing Key Lab of Plant Resources Research and Development, Beijing Technology and Business University, Beijing, China. Email: [email protected]Search for more papers by this author First published: 22 December 2022 https://doi.org/10.1111/jdv.18832Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinkedInRedditWechat Early ViewOnline Version of Record before inclusion in an issue RelatedInformation