The authors build on configuration theory to argue that the alignment of a customer-centric strategy and a customer-centric structure allows a firm to increase firm performance through new product portfolio innovativeness. They further contend that the influence of customer-centric strategy-structure alignment on new product portfolio innovativeness can be amplified by increasing the firm’s strategic resource emphasis toward R D, relative to advertising. The model is tested using a 9-year panel dataset (2011–2019) involving 695 firm-year observations comprising 8,899 product launches across 91 firms. The findings indicate that new product portfolio innovativeness mediates the positive effect of customer-centric strategy-structure alignment on firm performance, and that the increase in strategic resource emphasis toward R D amplifies the effect of customer-centric strategy-structure alignment on new product portfolio innovativeness. Implications for theory and practice are discussed.

The emergence of conflict is a complex issue with numerous drivers and interactions playing a role. Exploratory dimension-reduction techniques can reveal patterns of association in such complex data. In this study, an existing dataset was reanalyzed using factor analysis for mixed data to visualize the data in two-dimensional space to explore the conditions associated with high levels of conflict. The first dimension was strongly associated with resilience index, control of corruption, income, income inequality, and regime type, while the second dimension was strongly associated with oil production, regime type, conflict level, political terror level, and water stress. Hierarchical clustering from principal components was used to group the observations into five clusters. Country trajectories through the two-dimensional space provided examples of how movement in the first two dimensions reflected changes in conflict, political terror, regime type, and resilience index. These trajectories correspond to the evolution of themes in research on conflict, particularly in terms of considering the importance of climate or environmental variables in stimulating or sustaining conflict. Understanding conditions associated with high conflict can be helpful in guiding the development of future models for prediction and risk assessment.

The perinatal transmission of HIV is preventable through a regimen that includes testing of all pregnant individuals, antiretroviral treatment (ART) for the pregnant individual, prophylactic or preventative ART for the infant, and cesarean section delivery for mothers with HIV viremia at the time of delivery. Under this protocol, the United States has seen a significant decline in the perinatal transmission of HIV and achieved a perinatal HIV transmission rate of 0.9% in 2019. However, despite this progress nationally and after zero transmissions in 2021, Maryland recorded 6 cases of perinatal HIV diagnoses in 2022. Each of the 3 major referral centers for pediatric HIV patients in Maryland reported 2 new cases in 2022. A root cause analysis of the cases identified risk factors including delayed entry into perinatal and HIV care, premature birth, maternal adherence challenges in the setting of substance use and other adverse social determinants of health, and failure to diagnose maternal HIV infection in a timely way. All patients were successfully linked to care and initiated on ART. Multiple factors contributed to the 2022 increase in cases of perinatal HIV in Maryland. To achieve and then sustain the elimination of perinatal HIV transmission, the constancy of systems that eliminate barriers for all pregnant people to access testing, prevention, and treatment is critical.

In response to socio-ecological challenges, commercial fishers have developed narratives that emphasize environmental stewardship based on traditional and local ecological/environmental knowledge (T/LEK) of coastal and marine natural and social environments. Observers of small- and medium-scale fishing families have characterized these narratives as advocacy for sustainable fisheries that present holistic understandings of environmental phenomena that both contrast with and complement fisheries science and fisheries management, primarily critical of focusing on individual species in fishery management plans and privatizing fishing resources through permitting and quota systems. Privatization, in turn, dovetails with the three interrelated processes of commodification, proletarianization, and globalization, all of which contribute to the challenges that commercial fishing attempts to counter in its narratives and in the changing fishing practices of younger fishers entering the industry. Along with considering approaches that emphasize stewardship, knowledge, and advocacy, a focus on value in fisheries is a helpful way of making sense of what fishers emphasize and what they ignore in their narratives.

Purpose Cross-border e-commerce continues to garner much attention within the international marketing literature as the world becomes hyperconnected through digital channels. Although there is an abundance of international marketing research on cross-border e-commerce, there is a lack of information regarding the influences of meta-institutional factors, such as a country’s level of globalization, on the relationship between digital advertising and cross-border e-commerce buyers. The objective of this research is to examine the effects of digital media ad spend at the country level on cross-border e-commerce buyers across countries under differing degrees of formal (i.e. political) and informal (i.e. cultural) institutional globalization. Design/methodology/approach This work examines the influence of digital ad spend at the country level and the degree of the country’s formal and informal institutional globalization on the share of cross-border e-commerce buyers. We examine this issue within a 21-country, 8-year, unbalanced panel dataset. Findings We find that there is substantive heterogeneity in degrees of formal (i.e. political) and informal (i.e. cultural) institutional globalization and cross-border e-commerce across countries. Digital ad spend at the country level is positively associated with cross-border e-commerce buyers within a country. A country’s level of political globalization enhances, but cultural globalization was found to dampen the positive association. The results indicate that political and cultural globalization of a country both contribute to increased interconnectedness with the global market, yet the nature of the interconnection differs. Originality/value The findings are informative to international marketing managers navigating the digital landscape and highlight the importance of institutions in international marketing activities. The study specifically demonstrates the varying effects of the meta-institutional factors of a country’s level of political and cultural globalization on the association between digital ad spend and cross-border e-commerce buyers at the country level, across a wide variety of countries, thus also contributing to the effort to improve generalizations from multi-country comparisons in international marketing research.

To cope with industry pressures and rising costs/risks of R&D, collaborations between manufacturers for new product development have become increasingly common. However, extant research presents contrasting opinions regarding product development within coopetitive relationships, characterized by simultaneous competition and collaboration. Drawing on the literature on coopetition and Resource Based View, we argue that to effectively develop new products within coopetitive relationships that are novel and meaningful, firms must understand the different roles that the shadow of the past and future play and how their influence changes under conditions of competitive intensity and market dynamism. We find, based on a survey of U.S. managers in 224 manufacturer collaborations, that a relationship's past and future have very different and often opposing effects in relation to novelty and meaningfulness. We also find that shadow of the past becomes an important resource under different environmental conditions than shadow of the future, highlighting the importance to treat each shadow as distinct. Further, we theoretically and empirically demonstrate that novelty and meaningfulness relate to different resource sharing mechanisms. For instance, we discover that competitive intensity affects the relationship between both shadows and novelty, while dynamism affects the relationship between both the shadows and meaningfulness.

Social media companies have become some of the most prominent multinational enterprises over the last few decades. In response to calls in the international business literature for a greater understanding of the externalities of multinational enterprises' activities, we employ the micro-macro level theory of purposeful group formation within society and the affordance-based framework to understand the association between the use of three popular global social media platforms (i.e., Facebook, Twitter, Instagram) and the prevalence of anxiety at the country-level while accounting for heterogeneity in country institutional environments, using a 30-country, eleven-year, unbalanced panel dataset. We further explore whether informal institutional elements (i.e., national culture) are associated with the prevalence of anxiety and/or moderate the association between the use of social media and the prevalence of anxiety. Our findings indicate that the use of all three social media platforms, when considered as a percentage of the population using each platform, are negatively associated with the prevalence of anxiety in a country, with Twitter having the strongest association. We also find that the informal institutional elements have important moderating effects when considering the influence of the use of social media on the prevalence of anxiety across countries.

Estuaries and coastal forests, including the coastal fisheries they support, are among the most biodiverse and productive ecosystems on Earth. In Southern Puerto Rico (SPR), there is a culturally significant emic category of estuarine/coastal forest resource utilization known as “Pesca de monte” (tropical coastal forest fisheries, TCF fisheries hereafter) that constitute a parallel activity to commercial fisheries underreported in fishery statistics. Our three years of field research revealed that SPR communities derive considerable value from TCF resources, showing multiple engagements with these environments and wide-spectrum resource dependency. The value generated by TCF use includes the social and cultural acts of production and exchange in households, neighborhoods, and communities, whether the resources are sold, bartered, given as gifts, or consumed directly. Coastal policy that fails to protect productive TCF landscapes or hinders community access to these resources risks degrading human well-being around the coast. We discuss the implication of our findings for coastal policy in TCF fishery dependent regions such as SPR.

PurposeThe COVID-19 pandemic highlights the influence that nation-states can have on the engagement of international marketing activities. The purpose of this study is to understand the influence of the institutional response to the COVID-19 pandemic on international marketing activities and to highlight the need to formally incorporate institutional economics into the study of international marketing phenomena.Design/methodology/approachThe paper uses institutional economics as the environmental element of the general theory of competitive rationality to present a foundation for understanding how state actions influence marketing and international marketing activities. Data are presented and empirically tested, demonstrating the heterogeneity of government influence on personal and economic freedoms during the pandemic, both of which influenced international marketing activities. To broaden the implications of this work, we also provide anecdotal illustrations unrelated to the COVID-19 pandemic to demonstrate the breadth of nation-state influence on international marketing activities.FindingsHeterogeneity in nation-state formal and informal institutional elements influence international marketing activities during the COVID-19 pandemic. However, other incidents, unrelated to the COVID-19 pandemic, demonstrate the importance of contextualizing international marketing activities under a holistic institutional framework.Originality/valueThe paper employs the general theory of competitive rationality along with institutional economics to provide a theoretical foundation to better understand the differential impact on international marketing as a result of formal and informal institutional influences. This general framework can be employed to provide a holistic understanding of both international and cross-national marketing activities.

The marketing literature has long recognized the positive relationship between advertising spending and sales at the firm level. However, this literature overlooks country-level heterogeneity of both the advertising channel and retail format evolution, limiting global managers’ understanding of the heterogeneity and evolution of advertising channels and retail formats across country markets and, therefore, managers’ ability to effectively formulate a global marketing strategy that adjusts for such differences. The authors call for a glocal approach when considering the association between ad spend by media channels and retail format sales at the country level, accounting for country institutional environments. They explore this topic using a 29-country, seven-year unbalanced panel data set. The authors find that there is substantive heterogeneity in ad spend by media channels and retail format sales across countries. Further, they find that changes in ad spend in specific media channels are positively associated with changes in related retail format sales at the country level, whereas the associations between changes in ad spend in media channels with unrelated retail format sales are more nuanced. The findings are informative to international marketing managers navigating the complex and ever-evolving retail landscape and highlight the importance of thinking globally while acting locally.

The synthesis of imidazole fused spirocyclic ketones as templates for acetyl-CoA carboxylase (ACC) inhibitors is reported. By completing the spirocyclic ring closure via divergent pathways, the synthesis of these regioisomers from common intermediates was developed. Through an aldehyde homologation/ transmetalation strategy, one isomer was formed selectively. The second desired isomer was obtained via an intramolecular aromatic homolytic substitution reaction. Preparation of these isomeric spiroketones provided templates which, upon elaboration, led to key structure-activity relationship (SAR) points for delivery of potent ACC inhibitors.

Research on migration has become more challenging due to at least four factors: (1) more complex migration traditions; (2) the development of migration economies that engage many types of migrants from ever more social and cultural backgrounds; (3) increasing likelihood of climate change-driven environmental migration; and (4) increasing likelihood of conflict-based migration in some contexts. These developments have shaken economic theories of migration and have encouraged interdisciplinary, methodologically mixed, qualitative and quantitative research and analysis. From a review of the literature, we have gleaned 11 common themes about environmental, economic and conflict migration that we differentiate by process (migration behaviours that are still evolving) and patterns (migration behaviours that have become customary). We then consider how positive and negative dimensions of migration can be captured and represented with close attention to livelihood constellations (multiple economic activities combined by individuals, households and families). Finally, focusing on Somalia and agro-pastoral peoples generally, where recent environmental and conflict migration have been added to decades of economic migration and centuries of seasonal, environmental migration associated with pastoralism, we combine historical and qualitative work to demonstrate the value of a livelihood constellation perspective.

Concerns have been raised as to the potentially deleterious effects of advertising on society. We examine this issue given the recent calls to explore the societal effects of international business activities, the substantive nature of advertising spending globally, and the movement by governments to hold businesses accountable for societal harms. We build upon the general theory of competitive rationality, suggesting a positive relationship between advertising spending and happiness at the country level. We integrate an institutional economics framework into the general theory of competitive rationality to understand country effects. We explore whether institutional environments (i.e., political, regulatory, and social) are associated with happiness and/or moderate the relationship between advertising spending and happiness. We empirically examine these relationships using a 34-country, 9-year unbalanced panel dataset. Our findings indicate that advertising spending at the country level is positively associated with happiness, even when accounting for country-level institutional direct and moderating effects. We discuss our results in comparison to prior findings, highlighting implications for international marketing theory and practice, and setting forth a foundation for debate and research in the field.

Traditional wage labor has experienced a significant decline in industrialized countries over the past few decades. The spread of temporary work, the proliferation of subcontracting arrangements, the use of artificial intelligence (AI), the shipment of manufacturing jobs overseas, and the employment of foreign contract workers are among the key factors driving this decline. The result is a rise of labor insecurity and fragmentation among increasingly diverse forms of flexible labor arrangements. This book examines this important transformation by considering the impact of foreign contract labor on temporary migrant workers in their places of employment and home communities. It assesses work as a source of value in capitalist, reproductive, domestic, and cultural economics, and argues for a new, work-centric field of economics. Rich in examples, it is a sophisticated anthropological appreciation of the many forms that work can take and what these forms mean for the creation of value in people's lives.

Peptide agonists of the glucagon-like peptide-1 receptor (GLP-1R) have revolutionized diabetes therapy, but their use has been limited because they require injection. Herein, we describe the discovery of the orally bioavailable, small-molecule, GLP-1R agonist PF-06882961 (danuglipron). A sensitized high-throughput screen was used to identify 5-fluoropyrimidine-based GLP-1R agonists that were optimized to promote endogenous GLP-1R signaling with nanomolar potency. Incorporation of a carboxylic acid moiety provided considerable GLP-1R potency gains with improved off-target pharmacology and reduced metabolic clearance, ultimately resulting in the identification of danuglipron. Danuglipron increased insulin levels in primates but not rodents, which was explained by receptor mutagensis studies and a cryogenic electron microscope structure that revealed a binding pocket requiring a primate-specific tryptophan 33 residue. Oral administration of danuglipron to healthy humans produced dose-proportional increases in systemic exposure (NCT03309241). This opens an opportunity for oral small-molecule therapies that target the well-validated GLP-1R for metabolic health.

Purpose Social media is a product that is co-created by consumers and multinational enterprises, that partially manage the customer experience and that has garnered significant attention in the field of international marketing. However, international marketing scholars have yet to address the societal costs of the use of social media, even as academics in other disciplines and business leaders are raising alarm that social media has created a digital ecosystem that may harm individuals within the global market. The objective of this research is to examine the generalizability of the relationship between the use of social media and the prevalence of depression across countries. Design/methodology/approach Employing social cohesion theory and the social network approach of the strength of ties, this work examines the relationship between the use of social media and time spent on social media at the country level and the prevalence of depression. The authors examine this issue within a 28-country, eight-year, unbalanced panel dataset, accounting for cultural, economic and structural factors. Findings The authors find that as more people within a country use social media, the prevalence of depression in that country increases. However, the authors also find that as the average time spent on social media in a country increases the deleterious relationship between the use of social media and the prevalence of depression diminishes. Originality/value Answering the calls in the international marketing literature for a greater understanding of the externalities (i.e. consumer well-being effects) of marketing activities of multinational companies, this study demonstrates the varying relationships of the use of and time spent on social media and the prevalence of depression at the population level, across a wide variety of countries, thus also contributing to the effort to improving generalizations from multi-country comparisons in international research.

Building strong relationships is central to the development and maintenance of effective industrial channels. However, while the relationship marketing literature is vast, our understanding of how multidyadic industrial channels impact relationship marketing models is limited. As many OEM supplier relationships are formed via component supplier specification by its industrial buyer, where freedom to enter and exit a relationship is externally restricted, the current relationship marketing literature is somewhat limited in explaining these relationships. This study examines the underlying differences in relationship marketing across the cases of component supplier specification and non-component supplier specification. We discuss key relationship variable differences across cases within the phases of relationship development, and the extant relationship marketing literature. We then present a research agenda for advancing our understanding of multidyadic industrial channels.

Cultural distance is an important element in the study of international marketing phenomena. However, scholars have voiced significant concerns with its use. Although reviews of cultural distance have been conducted, no research has yet directly addressed how the choices that scholars make in relation to the conceptualization and operationalization of cultural distance influence our understanding of its role in international marketing phenomena. In this work, the authors review concerns pertaining to cultural distance and use them as a foundation to systematically analyze 83 articles referencing cultural distance in the international marketing literature to understand the choices that have been made. They find significant heterogeneity in conceptualization and operationalization of cultural distance. Then, they examine the empirical consequences of this choice heterogeneity within a single data set of 148 suppliers to a European original equipment manufacturer. The findings demonstrate that differences in conceptualizations and operationalizations significantly influence the observed effects of cultural distance and, thus, the understanding of its role in international marketing phenomena. Last, the authors put forth a series of recommendations aimed to enhance the discipline's ability to build a strong foundation of knowledge of cultural distance's role in international marketing phenomena.