BETH Israel Hospital is the real name of a Harvard Medical School teaching hospital that I shall assume is known to everyone attending this seminar. Northbridge is the fictitious name of a city in the Greater Boston area that is also known, at least by (real) name, to many of us. Both are profoundly affected by the widely advertised crisis in health care in the United States.Instead of considering that crisis in the abstract, as has been done so frequently in recent months, I shall focus on the resultant difficulties and challenges for the Beth Israel Hospital and for . . .

RECOGNITION of the role of human hemoglobin variants in the pathogenesis of disorders associated with sickling and with thalassemia constituted one of the most important advances in hematology during the last 20 years. More recent has been the realization that variants of human hemoglobin may be associated with other clinical syndromes: variants having altered oxygen equilibria, such as the M hemoglobins, may produce cyanosis or erythrocytosis, whereas unstable variants are associated with congenital Heinz-body anemias.In few fields of clinical investigation can one so clearly relate the clinical presentation of the patient to the molecular aspects of his disorder. However, . . .

THAT man has daily rhythms of body temperature, excretion and many other functions has been known for a very long time. Only recently has it been widely appreciated, however, that these rhythms are driven from within by a elocklike mechanism — that they are not simply a response to the environmental periodicities associated with the rotation of the earth, to which all life on this planet is subjected and wherein it has evolved. The role and importance of these living clocks in human physiology is only beginning to be appreciated. Today especially, in the age of jet and space travel, . . .

HomeCirculationVol. 22, No. 4CIRCULATION Free AccessResearch ArticlePDF/EPUBAboutView PDFSections ToolsAdd to favoritesDownload citationsTrack citationsPermissions ShareShare onFacebookTwitterLinked InMendeleyReddit Jump toFree AccessResearch ArticlePDF/EPUBCIRCULATION AN OFFICIAL JOURNAL OF THE AMERICAN HEART ASSOCIATION HERRMAN L. BLUMGART, EDITH E. PARRIS, STANFORD WESSLER and PAUL M. ZOLL HERRMAN L. BLUMGARTHERRMAN L. BLUMGART Editor-in-Chief 330 Brookline Avenue, Boston 15, Mass.Assistant EditorASSOCIATE EDITOR, Boston, Mass. , EDITH E. PARRISEDITH E. PARRIS Editor-in-Chief 330 Brookline Avenue, Boston 15, Mass.Assistant EditorASSOCIATE EDITOR, Boston, Mass. , STANFORD WESSLERSTANFORD WESSLER Editor-in-Chief 330 Brookline Avenue, Boston 15, Mass.Assistant EditorASSOCIATE EDITOR, Boston, Mass. and PAUL M. ZOLLPAUL M. ZOLL Editor-in-Chief 330 Brookline Avenue, Boston 15, Mass.Assistant EditorASSOCIATE EDITOR, Boston, Mass. Originally published1 Oct 1960https://doi.org/10.1161/01.CIR.22.4.693Circulation. 1960;22:693–847FootnotesCorrespondence concerning editorial matters should be addressed to the Editor-in-Chief, at the above address. All communications concerning business matters, including change of address, should be addressed to the Publishing Director, American Heart Association, 44 East 23rd Street, New York 10, N. Y. Previous Back to top Next FiguresReferencesRelatedDetails October 1, 1960Vol 22, Issue 4 Advertisement Article InformationMetrics © 1960 American Heart Association, Inc.https://doi.org/10.1161/01.CIR.22.4.693 Originally publishedOctober 1, 1960 PDF download Advertisement