Chromosomal karyotype analysis is crucial for diagnosing and managing hematologic malignancies, yet inconsistent protocols compromise reliability. To standardize practices, this consensus integrates international guidelines (WHO, ICC, ELN) with clinical expertise, providing evidence-based recommendations for specimen collection, cell culture, chromosome harvesting, banding techniques, karyotype analysis, and reporting. By establishing uniform operational standards, this initiative seeks to mitigate variability, improve detection rates, and support precision medicine in hematologic malignancies.

Pediatric Blood & CancerEarly View e30908 LETTER TO THE EDITOR Concurrent EPOR::IGH fusion gene and numerous cytoplasmic granules in BCR::ABL1-like B-lymphoblastic leukemia Fang Long, Fang Long orcid.org/0000-0001-7429-1996 Department of Clinical Laboratory, Sichuan Provincial Maternity and Child Health Care Hospital, The Affiliated Women's and Children's Hospital of Chengdu Medical College, Chengdu, Sichuan, ChinaSearch for more papers by this authorMingming Bai, Mingming Bai Department of Experimental Diagnostics, Shijiazhuang Pingan Hospital, Shijiazhuang, Hebei, ChinaSearch for more papers by this authorFan Zheng, Fan Zheng Department of Experimental Diagnostics, Shijiazhuang Pingan Hospital, Shijiazhuang, Hebei, ChinaSearch for more papers by this authorTing Li, Corresponding Author Ting Li [email protected] orcid.org/0000-0002-2027-9462 Department of Laboratory Medicine, Beijing Ludaopei Hospital, Beijing, China Correspondence Xiaohui Zhang, Department of Experimental Diagnostics, Shijiazhuang Pingan Hospital, No. 48 Cangfeng Rd, Yuhua District, Shijiazhuang, Hebei Province, 050021, China. Email: [email protected] Ting Li, Department of Laboratory Medicine, Beijing Ludaopei Hospital, No. 22 Tongji South Rd, Yizhuang Economic-Technological Development Area, Beijing 100176, China. Email: [email protected].Search for more papers by this authorXiaohui Zhang, Corresponding Author Xiaohui Zhang [email protected] orcid.org/0009-0006-9958-5310 Department of Experimental Diagnostics, Shijiazhuang Pingan Hospital, Shijiazhuang, Hebei, China Correspondence Xiaohui Zhang, Department of Experimental Diagnostics, Shijiazhuang Pingan Hospital, No. 48 Cangfeng Rd, Yuhua District, Shijiazhuang, Hebei Province, 050021, China. Email: [email protected] Ting Li, Department of Laboratory Medicine, Beijing Ludaopei Hospital, No. 22 Tongji South Rd, Yizhuang Economic-Technological Development Area, Beijing 100176, China. Email: [email protected].Search for more papers by this author Fang Long, Fang Long orcid.org/0000-0001-7429-1996 Department of Clinical Laboratory, Sichuan Provincial Maternity and Child Health Care Hospital, The Affiliated Women's and Children's Hospital of Chengdu Medical College, Chengdu, Sichuan, ChinaSearch for more papers by this authorMingming Bai, Mingming Bai Department of Experimental Diagnostics, Shijiazhuang Pingan Hospital, Shijiazhuang, Hebei, ChinaSearch for more papers by this authorFan Zheng, Fan Zheng Department of Experimental Diagnostics, Shijiazhuang Pingan Hospital, Shijiazhuang, Hebei, ChinaSearch for more papers by this authorTing Li, Corresponding Author Ting Li [email protected] orcid.org/0000-0002-2027-9462 Department of Laboratory Medicine, Beijing Ludaopei Hospital, Beijing, China Correspondence Xiaohui Zhang, Department of Experimental Diagnostics, Shijiazhuang Pingan Hospital, No. 48 Cangfeng Rd, Yuhua District, Shijiazhuang, Hebei Province, 050021, China. Email: [email protected] Ting Li, Department of Laboratory Medicine, Beijing Ludaopei Hospital, No. 22 Tongji South Rd, Yizhuang Economic-Technological Development Area, Beijing 100176, China. Email: [email protected].Search for more papers by this authorXiaohui Zhang, Corresponding Author Xiaohui Zhang [email protected] orcid.org/0009-0006-9958-5310 Department of Experimental Diagnostics, Shijiazhuang Pingan Hospital, Shijiazhuang, Hebei, China Correspondence Xiaohui Zhang, Department of Experimental Diagnostics, Shijiazhuang Pingan Hospital, No. 48 Cangfeng Rd, Yuhua District, Shijiazhuang, Hebei Province, 050021, China. Email: [email protected] Ting Li, Department of Laboratory Medicine, Beijing Ludaopei Hospital, No. 22 Tongji South Rd, Yizhuang Economic-Technological Development Area, Beijing 100176, China. Email: [email protected].Search for more papers by this author First published: 01 February 2024 https://doi.org/10.1002/pbc.30908Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onEmailFacebookTwitterLinkedInRedditWechat No abstract is available for this article. REFERENCES 1Borowitz MJ, Chan JKC, Downing JR. B-lymphoblastic leukemia/lymphoma with recurrent cytogenetic abnormalities. In: SH Swerdlow, E Campo, NL Harris, eds. WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues. Revised. 4th ed. IARC; 2017: 208. Google Scholar 2Conant JL, Czuchlewski DR. BCR-ABL1-like B-lymphoblastic leukemia/lymphoma: review of the entity and detection methodologies. Int J Lab Hematol. 2019; 41(1): 126-130. 10.1111/ijlh.13012 PubMedGoogle Scholar 3Pitman SD, Huang Q. Granular acute lymphoblastic leukemia: a case report and literature review. Am J Hematol. 2007; 82(9): 834-837. 10.1002/ajh.20922 PubMedWeb of Science®Google Scholar 4Cerezo L, Shuster JJ, Pullen DJ, et al. Laboratory correlates and prognostic significance of granular acute lymphoblastic leukemia in children. A Pediatric Oncology Group study. Am J Clin Pathol. 1991; 95(4): 526-531. 10.1093/ajcp/95.4.526 CASPubMedWeb of Science®Google Scholar 5Sun JB, Lu YY, Huang LL, et al. Characteristics of blood transfusion during induction remission in children with acute lymphoblastic leukemia: a single-center retrospective investigation. J Pediatr Hematol Oncol. 2020; 42(6): e410-e415. 10.1097/MPH.0000000000001741 CASPubMedWeb of Science®Google Scholar 6Chu J, Cai H, Cai J, et al. Prognostic significance of steroid response in pediatric acute lymphoblastic leukemia: the CCCG-ALL-2015 study. Front Oncol. 2022; 12:1062065. 10.3389/fonc.2022.1062065 CASPubMedGoogle Scholar 7Yang W, Cai J, Shen S, et al. Pulse therapy with vincristine and dexamethasone for childhood acute lymphoblastic leukaemia (CCCG-ALL-2015): an open-label, multicentre, randomised, phase 3, non-inferiority trial. Lancet Oncol. 2021; 22(9): 1322-1332. 10.1016/S1470-2045(21)00328-4 CASPubMedWeb of Science®Google Scholar 8Stein P, Peiper S, Butler D, et al. Granular acute lymphoblastic leukemia. Am J Clin Pathol. 1983; 79(4): 426-430. 10.1093/ajcp/79.4.426 CASPubMedWeb of Science®Google Scholar 9Invernizzi R, Rosanda C, Basso G, et al. Granular acute lymphoblastic leukemia in children. "AIEOP Cooperative Group for Cytology of Acute Leukemias." Haematologica. 1992; 77(1): 30-34. CASPubMedWeb of Science®Google Scholar Early ViewOnline Version of Record before inclusion in an issuee30908 ReferencesRelatedInformation

British Journal of HaematologyEarly View IMAGES IN HAEMATOLOGY Haematoidin in chronic myelomonocytic leukaemia during irregular treatment with hydroxycarbamide Xiaohui Zhang, Xiaohui Zhang Department of Experimental Diagnostics, Shijiazhuang Pingan Hospital, Shijiazhuang, Hebei, ChinaSearch for more papers by this authorChaoxin Tao, Chaoxin Tao Department of Experimental Diagnostics, Shijiazhuang Pingan Hospital, Shijiazhuang, Hebei, ChinaSearch for more papers by this authorFang long, Corresponding Author Fang long [email protected] orcid.org/0000-0001-7429-1996 Department of Clinical Laboratory, Sichuan Provincial Maternity and Child Health Care Hospital, The Affiliated Women's and Children's Hospital of Chengdu Medical College, Chengdu, Sichuan Province, ChinaSearch for more papers by this author Xiaohui Zhang, Xiaohui Zhang Department of Experimental Diagnostics, Shijiazhuang Pingan Hospital, Shijiazhuang, Hebei, ChinaSearch for more papers by this authorChaoxin Tao, Chaoxin Tao Department of Experimental Diagnostics, Shijiazhuang Pingan Hospital, Shijiazhuang, Hebei, ChinaSearch for more papers by this authorFang long, Corresponding Author Fang long [email protected] orcid.org/0000-0001-7429-1996 Department of Clinical Laboratory, Sichuan Provincial Maternity and Child Health Care Hospital, The Affiliated Women's and Children's Hospital of Chengdu Medical College, Chengdu, Sichuan Province, ChinaSearch for more papers by this author First published: 25 March 2024 https://doi.org/10.1111/bjh.19343Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onEmailFacebookTwitterLinkedInRedditWechat No abstract is available for this article. Early ViewOnline Version of Record before inclusion in an issue RelatedInformation

Data sharing is not applicable to this article as no new data were created or analyzed in this study.

Pediatric Blood & CancerEarly View e30512 LETTER TO THE EDITOR Cleaved lymphocytes in an infant with bilateral bronchopneumonia associated with Escherichia coli infection Yun Zhang, Yun Zhang Department of Clinical Laboratory, The District People's Hospital of Zhangqiu, Jinan, Shandong, ChinaSearch for more papers by this authorXiuchun Gong, Xiuchun Gong Department of Clinical Laboratory, The District People's Hospital of Zhangqiu, Jinan, Shandong, ChinaSearch for more papers by this authorXue Li, Xue Li Department of Health Ward, The District People's Hospital of Zhangqiu, Jinan, Shandong, ChinaSearch for more papers by this authorShichun Li, Shichun Li Department of Ultrasonography, The District People's Hospital of Zhangqiu, Jinan, Shandong, ChinaSearch for more papers by this authorFang Long, Fang Long Department of Clinical Laboratory, Sichuan Provincial Maternity and Child Health Care Hospital, The Affiliated Women's and Children's Hospital of Chengdu Medical College, Chengdu, Sichuan, ChinaSearch for more papers by this authorTing Li, Corresponding Author Ting Li [email protected] orcid.org/0000-0002-2027-9462 Department of Laboratory Medicine, Beijing Ludaopei Hospital, Beijing, China Correspondence Ting Li, Department of Laboratory Medicine, Beijing Ludaopei Hospital, No. 22 Tongji South Rd, Yizhuang Economic-Technological Development Area, Beijing, 100176, China. Email: [email protected]Search for more papers by this author Yun Zhang, Yun Zhang Department of Clinical Laboratory, The District People's Hospital of Zhangqiu, Jinan, Shandong, ChinaSearch for more papers by this authorXiuchun Gong, Xiuchun Gong Department of Clinical Laboratory, The District People's Hospital of Zhangqiu, Jinan, Shandong, ChinaSearch for more papers by this authorXue Li, Xue Li Department of Health Ward, The District People's Hospital of Zhangqiu, Jinan, Shandong, ChinaSearch for more papers by this authorShichun Li, Shichun Li Department of Ultrasonography, The District People's Hospital of Zhangqiu, Jinan, Shandong, ChinaSearch for more papers by this authorFang Long, Fang Long Department of Clinical Laboratory, Sichuan Provincial Maternity and Child Health Care Hospital, The Affiliated Women's and Children's Hospital of Chengdu Medical College, Chengdu, Sichuan, ChinaSearch for more papers by this authorTing Li, Corresponding Author Ting Li [email protected] orcid.org/0000-0002-2027-9462 Department of Laboratory Medicine, Beijing Ludaopei Hospital, Beijing, China Correspondence Ting Li, Department of Laboratory Medicine, Beijing Ludaopei Hospital, No. 22 Tongji South Rd, Yizhuang Economic-Technological Development Area, Beijing, 100176, China. Email: [email protected]Search for more papers by this author First published: 19 June 2023 https://doi.org/10.1002/pbc.30512Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onEmailFacebookTwitterLinkedInRedditWechat No abstract is available for this article. REFERENCES 1Funaki T, Miyairi I. Lymphocytosis in a baby with pertussis. Lancet Infect Dis. 2015; 15(1): 130. 2Kishimoto K, Kitamura T, Fujita K, Tate G, Mitsuya T. Cytologic differential diagnosis of follicular lymphoma grades 1 and 2 from reactive follicular hyperplasia: cytologic features of fine-needle aspiration smears with Pap stain and fluorescence in situ hybridization analysis to detect t(14;18)(q32;q21) chromosomal translocation. Diagn Cytopathol. 2006; 34(1): 11-17. 3Gonzalez H, Maloum K, Remy F, Merle-Beral H, Lesty C. Cleaved lymphocytes in chronic lymphocytic leukemia: a detailed retrospective analysis of diagnostic features. Leuk Lymphoma. 2002; 43(3): 555-564. 4Zhang R, Wang H, Li C, Chen Y, Xu G, Deng J. Utility of cleaved lymphocytes from peripheral blood smear in the diagnosis of pertussis. Int J Lab Hematol. 2021; 43(1): e26-e27. 5Bonacina D, Buoro S, Callegaro AP, Nacoti M. Lymphocyte morphology supports early diagnosis of Bordetella pertussis infection in neonates. Intensive Care Med. 2019; 45(6): 894-895. 6Dardick I, Sinnott NM, Hall R, Bajenko-Carr TA, Setterfield G. Nuclear morphology and morphometry of B-lymphocyte transformation. Implications for follicular center cell lymphomas. Am J Pathol. 1983; 111(1): 35-49. Early ViewOnline Version of Record before inclusion in an issuee30512 ReferencesRelatedInformation

British Journal of HaematologyVolume 201, Issue 6 p. 1018-1018 IMAGES IN HAEMATOLOGY Circulating tumor cells in clear cell sarcoma Yun Zhang, Yun Zhang orcid.org/0000-0001-5958-5494 Department of Clinical Laboratory, The District People’s Hospital of Zhangqiu, Jinan, ChinaSearch for more papers by this authorNa Guo, Na Guo Department of Blood Transfusion, The District People’s Hospital of Zhangqiu, Jinan, ChinaSearch for more papers by this authorNing Shen, Ning Shen Department of Medical Oncology, The District People’s Hospital of Zhangqiu, Jinan, ChinaSearch for more papers by this authorKechao Li, Kechao Li Department of Clinical Laboratory, The District People’s Hospital of Zhangqiu, Jinan, ChinaSearch for more papers by this authorJie Zheng, Jie Zheng orcid.org/0000-0001-9638-0199 Department of Hematology, The District People's Hospital of Zhangqiu, Jinan, Shandong Province, ChinaSearch for more papers by this authorTing Li, Ting Li orcid.org/0000-0002-2027-9462 Department of Flow Cytometry, Beijing Ludaopei Hospital, Beijing, ChinaSearch for more papers by this authorFang Long, Corresponding Author Fang Long [email protected] orcid.org/0000-0001-7429-1996 Department of Clinical Laboratory, Sichuan Provincial Maternity and Child Health Care Hospital, The Affiliated Women's and Children's Hospital of Chengdu Medical College, Chengdu, Sichuan Province, ChinaSearch for more papers by this author Yun Zhang, Yun Zhang orcid.org/0000-0001-5958-5494 Department of Clinical Laboratory, The District People’s Hospital of Zhangqiu, Jinan, ChinaSearch for more papers by this authorNa Guo, Na Guo Department of Blood Transfusion, The District People’s Hospital of Zhangqiu, Jinan, ChinaSearch for more papers by this authorNing Shen, Ning Shen Department of Medical Oncology, The District People’s Hospital of Zhangqiu, Jinan, ChinaSearch for more papers by this authorKechao Li, Kechao Li Department of Clinical Laboratory, The District People’s Hospital of Zhangqiu, Jinan, ChinaSearch for more papers by this authorJie Zheng, Jie Zheng orcid.org/0000-0001-9638-0199 Department of Hematology, The District People's Hospital of Zhangqiu, Jinan, Shandong Province, ChinaSearch for more papers by this authorTing Li, Ting Li orcid.org/0000-0002-2027-9462 Department of Flow Cytometry, Beijing Ludaopei Hospital, Beijing, ChinaSearch for more papers by this authorFang Long, Corresponding Author Fang Long [email protected] orcid.org/0000-0001-7429-1996 Department of Clinical Laboratory, Sichuan Provincial Maternity and Child Health Care Hospital, The Affiliated Women's and Children's Hospital of Chengdu Medical College, Chengdu, Sichuan Province, ChinaSearch for more papers by this author First published: 25 April 2023 https://doi.org/10.1111/bjh.18803Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onEmailFacebookTwitterLinkedInRedditWechat No abstract is available for this article. Volume201, Issue6June 2023Pages 1018-1018 RelatedInformation

with low blast count is seen very rarely and accurate data are not available. Concurrent secondary HLH and blast count below 20% in AML with RUNX1::RUNX1T1 is an extremely uncommon event. To date, only one pediatric case of AML with low blast count concomitant with HLH has been documented [4]. Thus, the rare adult case presented here highlights the importance of morphology and combining molecular techniques to characterize and confirm the diagnosis of AML with recurrent genetic abnormalities, especially in certain cases with low blast counts.

To the Editor: Rearrangements of the transcription factor zinc finger 384 (ZNF384) are found in 3%−4% of pediatric B-cell acute lymphoblastic leukemia (B-ALL)1 and approximately half of all childhood B/myeloid mixed phenotype acute leukemias (B/myeloid MPAL).2 Patients with ZNF384 rearrangements have particular immunophenotype profiles, often expressing myeloid markers with higher CD13 and CD33 proportion, and lower CD10 frequency than non-ZNF384 entities.3 Therefore, some scholars have suggested that they could be named as a new subtype of acute leukemia in the recent International Consensus Classification (ICC) classification, according to their unique clinical, immunophenotypic, cytogenetic and molecular characteristics.4 ZNF384 possesses numerous fusion partners, with EP300, TCF3, and TAF15 being the most common.5 As is well known, most patients with ALL can manifest with hematological symptoms, including pallor, fatigue, and bleeding signs, while some might present with significant musculoskeletal symptoms such as a limp and localized or diffuse bone pains.6 Osteomyelitis can occur in the initial or recurrent stages of leukemia. Here, we describe a pediatric B-ALL patient with infrequent ARID1B::ZNF384 gene fusion with multifocal osteomyelitis as his first symptom. A 12-year-old female was admitted with symptoms of bone pain at multiple sites: both lower limbs and left upper extremity. Physical examination revealed mild tenderness over the lower limbs and left upper extremity. A complete blood count demonstrated slight leukocytosis with white blood count 16.63 × 109/L, hemoglobin 149 g/L, and mild thrombocytosis with platelets 449 × 109/L. Magnetic resonance imaging of extremities showed slightly active metabolism with bone abnormalities in the upper part of right tibia. An initial diagnosis of osteomyelitis was established, and the child was treated with intravenous antibiotics. However, the effect was not satisfactory and she continued to have bone pain. Blood cultures were performed but without positive findings. Large numbers of blasts (comprising 44%) were noted on blood smear (Figure 1A–B), strongly suggestive of acute leukemia. Bone marrow aspiration revealed 60% blasts with a high nuclear-cytoplasmic ratio, round nuclei, scant light-blue cytoplasm, dispersed nuclear chromatin, and multiple variably prominent nucleoli (Figure 1C–D). Flow cytometry analysis indicated the abnormal blast cells were positive for CD34, CD19, and HLA-DR, partially positive for CD10, CD33, and CD20(dim), and negative for CD3, CD7, CD13, CD14, CD56, CD64, CD117, andmyeloperoxidase. Karyotype analysis

Pediatric Blood & CancerEarly View e30587 LETTER TO THE EDITOR A neonatal case of concurrent Enterobacter cloacae bacteremia and green neutrophil inclusions on peripheral blood smear Fang Long, Fang Long orcid.org/0000-0001-7429-1996 Department of Clinical Laboratory, Sichuan Provincial Maternity and Child Health Care Hospital, The Affiliated Women's and Children's Hospital of Chengdu Medical College, Chengdu, Sichuan Province, ChinaSearch for more papers by this authorTing Li, Ting Li orcid.org/0000-0002-2027-9462 Department of Laboratory Medicine, Beijing Ludaopei Hospital, Beijing, ChinaSearch for more papers by this authorLingsheng Meng, Lingsheng Meng Department of Clinical Laboratory, The District People's Hospital of Zhangqiu, Jinan, Shandong Province, ChinaSearch for more papers by this authorJiadong Yu, Jiadong Yu Department of Radiology, The District People's Hospital of Zhangqiu, Jinan, Shandong Province, ChinaSearch for more papers by this authorAichun Meng, Corresponding Author Aichun Meng [email protected] Department of Cardiology, The District People's Hospital of Zhangqiu, Jinan, Shandong Province, China Correspondence Yun Zhang, Department of Clinical Laboratory, The District People's Hospital of Zhangqiu, Jinan, Shandong Province, 250200, China. Email: [email protected] Aichun Meng, Department of Cardiology, The District People's Hospital of Zhangqiu, Jinan, Shandong Province, 250200, China Email: [email protected]Search for more papers by this authorYun Zhang, Corresponding Author Yun Zhang [email protected] orcid.org/0000-0002-0679-5348 Department of Clinical Laboratory, The District People's Hospital of Zhangqiu, Jinan, Shandong Province, China Correspondence Yun Zhang, Department of Clinical Laboratory, The District People's Hospital of Zhangqiu, Jinan, Shandong Province, 250200, China. Email: [email protected] Aichun Meng, Department of Cardiology, The District People's Hospital of Zhangqiu, Jinan, Shandong Province, 250200, China Email: [email protected]Search for more papers by this author Fang Long, Fang Long orcid.org/0000-0001-7429-1996 Department of Clinical Laboratory, Sichuan Provincial Maternity and Child Health Care Hospital, The Affiliated Women's and Children's Hospital of Chengdu Medical College, Chengdu, Sichuan Province, ChinaSearch for more papers by this authorTing Li, Ting Li orcid.org/0000-0002-2027-9462 Department of Laboratory Medicine, Beijing Ludaopei Hospital, Beijing, ChinaSearch for more papers by this authorLingsheng Meng, Lingsheng Meng Department of Clinical Laboratory, The District People's Hospital of Zhangqiu, Jinan, Shandong Province, ChinaSearch for more papers by this authorJiadong Yu, Jiadong Yu Department of Radiology, The District People's Hospital of Zhangqiu, Jinan, Shandong Province, ChinaSearch for more papers by this authorAichun Meng, Corresponding Author Aichun Meng [email protected] Department of Cardiology, The District People's Hospital of Zhangqiu, Jinan, Shandong Province, China Correspondence Yun Zhang, Department of Clinical Laboratory, The District People's Hospital of Zhangqiu, Jinan, Shandong Province, 250200, China. Email: [email protected] Aichun Meng, Department of Cardiology, The District People's Hospital of Zhangqiu, Jinan, Shandong Province, 250200, China Email: [email protected]Search for more papers by this authorYun Zhang, Corresponding Author Yun Zhang [email protected] orcid.org/0000-0002-0679-5348 Department of Clinical Laboratory, The District People's Hospital of Zhangqiu, Jinan, Shandong Province, China Correspondence Yun Zhang, Department of Clinical Laboratory, The District People's Hospital of Zhangqiu, Jinan, Shandong Province, 250200, China. Email: [email protected] Aichun Meng, Department of Cardiology, The District People's Hospital of Zhangqiu, Jinan, Shandong Province, 250200, China Email: [email protected]Search for more papers by this author First published: 17 July 2023 https://doi.org/10.1002/pbc.30587 Fang Long and Ting Li contributed equally to this work. Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onEmailFacebookTwitterLinkedInRedditWechat No abstract is available for this article. REFERENCES 1van der Meer W, Verwiel JM, Gidding CE, de Metz M, de Keijzer MH. Bacteria in blood smears: overwhelming sepsis or trivial contamination. Acta Haematol. 2002; 107(4): 220-223. 2Martins NNN, Jardim LL, Pereira LS, Rezende SM, Goncalves MLP. Blue-green cytoplasmic inclusions in neutrophils/monocytes of patients with yellow fever. Int J Lab Hematol. 2022; 44(4): e168-e171. 3Merino A, Molina A, Rodriguez-Garcia M, et al. Detection and significance of green inclusions in peripheral blood neutrophils and monocytes. Int J Lab Hematol. 2021; 43(2): e92-e94. 4Cantu MD, Towne WS, Emmons FN, et al. Clinical significance of blue-green neutrophil and monocyte cytoplasmic inclusions in SARS-CoV-2 positive critically ill patients. Br J Haematol. 2020; 190(2): e89-e92. 5Hodgson TO, Ruskova A, Shugg CJ, McCallum VJ, Morison IM. Green neutrophil and monocyte inclusions—time to acknowledge and report. Br J Haematol. 2015; 170(2): 229-235. 6Dalben M, Varkulja G, Basso M, et al. Investigation of an outbreak of Enterobacter cloacae in a neonatal unit and review of the literature. J Hosp Infect. 2008; 70(1): 7-14. 7van Rossem MC, de Waal WJ, van Hannen EJ, et al. Enterobacter colonisation in newborn infants: predictors, follow-up and implications for infection control. J Hosp Infect. 2007; 67(2): 142-148. 8Modi N, Damjanovic V, Cooke RW. Outbreak of cephalosporin resistant Enterobacter cloacae infection in a neonatal intensive care unit. Arch Dis Child. 1987; 62(2): 148-151. 9Fernandez-Baca V, Ballesteros F, Hervas JA, et al. Molecular epidemiological typing of Enterobacter cloacae isolates from a neonatal intensive care unit: three-year prospective study. J Hosp Infect. 2001; 49(3): 173-182. Early ViewOnline Version of Record before inclusion in an issuee30587 ReferencesRelatedInformation

Erythrophagocytosis by leukemic cells is an extremely uncommon phenomenon in acute myeloid leukemia (AML), with less than 1% in one previous research.This finding is typically associated with myelomonocytic or monocytic morphology (also designated as FAB-AML M4 or M5).The most common chromosomal anomalies includes the following: t(8;16) or its variants, inv(8)(p11q13) and t(16;21)(p11;q22), and less frequent in B-lymphoblastic leukemia (B-ALL) with ETV6-RUNX1 or BCR-ABL1.Besides, abundant cytoplasmic granules can occasionally occur in B-ALL, but rarely seen in T-lymphoblastic leukemia (T-ALL).Here, we describe a child diagnosed with de novo T-ALL with SIL-TAL1 fusion gene, with concurrence of numerous cytoplasmic granules and erythrophagocytosis by blast cells.This case emphasizes the great value of comprehensive diagnosis, with morphological as well as flow cytometry and molecular diagnostic technique playing a crucial role in the diagnosis of some leukemias with deceptive morphology.