Single cell TCR sequencing (scRNASeq) from patient cardiac and skeletal muscle tissue

Differentially expressed genes (DEGs) in IL1B+ Myeloid cell subsets and association of frequency of cytotoxic CD8+ T cells with clinical outcomes

Supplementary Figure 7: Identification of IL-17-producing cell types

Cell-cell communication analysis from fibroblasts, endothelial cells, and myeloid cells to cytotoxic T cells in myocarditis

Supplementary Figure 10: IL-17 directly stabilizes B7-H4 mRNA

Supplementary Figure 6: Stemness signature in pancreatic epithelial cells lacking IL-17RA.

Comparison of myeloid cell subclusters in cardiac muscle with previously reported subsets in human heart

Clinical characteristics of control patients

Analysis of CD45- subpopulations in cardiac muscle

Cell-cell communication analysis from endothelial cells and myeloid cells to cytotoxic T cells in myositis

Clinical characteristics of patients with confirmed toxicities

Analysis of CD45- subpopulations in cardiac muscle

Supplementary Figure 2. IL-17RA in the pancreatic immune compartment is not required for tumorigenesis.

Landscape of CD45- (non-immune) populations from patient cardiac and skeletal muscle tissues

Comparison of myeloid cell subclusters in skeletal muscle with previously reported subsets

Supplementary Figure 3. IL-17RA deletion results in an increase in apoptosis, but not proliferation at 30 week time point.

Clinical characteristics of individual patients with immune-related myocarditis and/or myositis

Supplementary Figure 4. Immunoprofiling of KC mice receiving Wild-Type (WT) Bone Marrow (BM) or Bone Marrow from IL-17RA Knock-Out (KO) Mice.

Hierarchical clustering based on Euclidean distance of expression in CD45- cells

Analysis of total CD45+ immune cell populations