目的 观察麝香保心丸对冠心病心绞痛病人血脂及血清炎症因子的影响.方法 将150例冠心病心绞痛病人按随机原则分为两组,各75例,对照组给予常规药物治疗,观察组在常规药物治疗基础上加用麝香保心丸,治疗疗程为4周.观察两组治疗前后白介素-6(IL-6)、白介素-10(IL-10)、肿瘤坏死因子-α(TNF-α)、超敏C-反应蛋白(hs-CRP)、总胆固醇(TC)、三酰甘油(TG)、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)水平变化,同时观察两组治疗前后心绞痛症状改善情况.结果 治疗后,观察组TC、TG均低于对照组,HDL-C高于对照组,差异均有统计学意义(P<0.05);治疗后,观察组心绞痛发作频率、持续时间、心绞痛积分、硝酸甘油用量都少于对照组,差异均有统计学意义(P<0.01);治疗后,观察组血清IL-6、TNF-α、hs-CRP均低于对照组,血清IL-10高于对照组,差异均有统计学意义(P<0.05).结论 麝香保心丸具有调节血脂,减轻病人冠状动脉血管局部炎症反应的作用.

目的 探讨经皮腔内冠状动脉成形术(PTCA)联合尿激酶原对急性心肌梗死(AMI)患者心肌再灌注及预后的影响.方法 连续入选2017年6月至2018年2月于南阳市中心医院心内科收治的AMI患者98例,随机分为PTCA组与联合组,每组49例.PTCA组给予PTCA治疗,联合组先行尿激酶原注射,后行PTCA治疗.评价两组患者术后心肌梗死溶栓(TIMI)血流分级、心肌灌注分级(TMP),检测肌酸激酶同工酶(CK-MB)水平.另外观察住院期间和出院后6个月发生主要不良心脏事件的情况.结果 联合组PTCA后TIMI血流分级、TMP分级均显著优于PTCA组(P均<0.05).与术前比较,两组术后12 h、24 h血清CK-MB水平均显著上升(P均<0.05);联合组术后12 h血清CK-MB水平显著低于PTCA组(P<0.05).住院期间联合组再发心绞痛发生率4.08％,显著低于PTCA组的18.37％(P<0.05),出血率两组比较无显著差异(P>0.05).联合组出院后6个月恶性心律失常发生率显著低于PTCA组(P<0.05).结论 PTCA联合尿激酶原能明显改善AMI患者心肌再灌注,且不增加出血风险,可有效减少不良心脏事件发生.

目的 探讨南阳地区空巢老年糖尿病患者自我管理水平与生活质量的相关性.方法 2016年1月-2017年12月借助中文版糖尿病自我管理行为量表(SDSCA)和中国糖尿病患者生存质量特异性量表(DSQL),对位于南阳市下设管辖区(宛城区、卧龙区及高新区)的3个南阳市中心医院社区门诊部就诊的224例空巢老年糖尿病患者进行问卷调查.结果 南阳地区空巢老年SDSCA得分为(34.87±2.05)分,得分较高的维度有特殊饮食和运动管理,得分较低的维度有普通饮食、服药管理、血糖自我监测及足部护理.年龄、文化程度、家庭年收入、亲人看望频率、性别等因素对患者自我管理水平均有一定影响.南阳地区空巢老年糖尿病患者DSQL得分为(65.41±3.63)分.相关性分析结果显示,普通饮食、运动管理、服药管理及足部护理与生活质量存在相关性(P＜0.01).结论 南阳地区空巢老年糖尿病患者自我管理水平及生活质量均处于较低水平,护理人员应重视并提高本地区空巢老年糖尿病患者对特殊饮食、运动管理、服药管理及足部护理等方面的自我管理,进而改善该类患者生活质量.

目的 探讨双心护理联合放松训练对老年冠心病介入治疗患者心理应激、睡眠质量和意外事件的影响.方法 选择2015年3月-2017年7月在我院接受介入治疗的116例老年冠心病患者,采用随机数字表法分为观察组和对照组各58例,对照组给予心血管介入治疗常规护理,观察组在常规护理的基础上实施双心护理联合放松训练,借助焦虑自评量表(SAS)、抑郁自评量表(SDS)和匹兹堡睡眠质量指数(PSQI)对两组患者实施相应护理前后心理应激指标和睡眠质量进行评价,并比较两组患者桡动脉穿刺成功率、并发症发生情况及介入意外事件发生率.结果 护理前两组患者均存在不同程度的焦虑、抑郁、睡眠质量差等心理应激反应,组间SAS、SDS和PSQI评分比较,差异无统计学意义(P＞0.05).经护理干预后,两组患者心理负面情绪均得到改善,观察组SAS和SDS评分明显较对照组低(P＜0.05);入睡时间、睡眠质量、睡眠时间等指标,观察组下降较对照组明显(P＜0.05);观察组桡动脉穿刺成功率高于对照组(P＜0.05);介入治疗并发症及意外事件发生率低于对照组(P＜0.05).结论 双心护理联合放松训练能够有效缓解老年冠心病介入治疗患者焦虑、抑郁、紧张情绪,降低心理应激程度,提高睡眠质量和桡动脉穿刺成功率,降低血管痉挛、穿刺部位血肿等意外事件发生率,对保证手术顺利完成具有重要意义.

Objective To investigate the change of lecithin cholesterol aeyltransferase (LCAT ) in diabetic patients with acute coronary syndromes (ACS) and analysis the relationship between LACT and cardiovascular event . Methods A total of 399 subjects were enrolled in this study and divided into three groups :diabetes mellitus with ACS group (DM + ACS ,n= 179) ,diabetes mellitus without ACS group (DM ,n= 120) and healthy subjects selected from medical examination center as normal control group (NC ,n=100) .Clinical characteristics and biochemical index were gathered from all the subjects .LCAT level was tested by ELISA .Then according to LCAT levels ,DM + ACS group were further divided into three groups by tertiles :low tertile subgroup (27.46 ～ 35.25 mg/ml ,n= 55 ) ,middle tertile subgroup (35.26～ 43.06 mg/ml ,n= 67)and the high tertile subgroup (43.07 ～ 50.86 mg/ml ,n= 57) . The relationship between different levels of LCAT and cardiovascular events were analyzed .Multivariate linear regression was used to analysis the influencing factors for LACT . Results (1)The percentage of insulin ,aspirin and CCB treatment were higher in DM +ACS group than in DM group[141(78.77％ )vs 65 (54.17％ );179(100.00％ )vs 114(95.00％ );88(49.16％ )vs 40(33.33％ ) ,P<0.05] .The levels of WC , BMI ,FPG ,HbA1c ,TC and LDL-C were higher ,while HDL-C and LCAT were lower in DM + ACS group and DM group than in NC group .Meanwhile ,the FPG ,HbA1 c ,TC and LDL-C were higher ,HDL-C and LCAT were lower in DM +ACS group than in DM group(P<0.05 or P<0.01);(2) Along with the rise of LCAT levels ,FPG ,2 hPG ,HbA1c ,TC and TG were reduced and HDL-C were increased (P<0.05) . During 6 months ,the number of cardiovascular events were lower in middle tertile subgroup and high tertile subgroup than in low tertile subgroup (0.49 vs 0.83 vs 1.84 time/n ,P<0.01);(3) Multivariate linear regression analysis showed that age ,FPG ,HbA1c and HDL-C were influence factors for LCAT (P<0.05 or P<0.01) . Conclusion The LCAT level was reduced in diabetic patient ,especially in diabetic patients with ACS .LCAT level maybe a predictor of cardiovascular event in diabetic patients with ACS . Age ,FPG ,HbA1 c and HDL-C were influence factors for LCAT .

目的 探讨灯盏花素注射液对急性心肌梗死患者细胞免疫、红细胞免疫及体液免疫的影响.方法 将74例急性心肌梗死患者按随机数字表法分为两组,每组37例.对照组接受常规对症治疗,观察组在对症治疗基础上静脉滴注灯盏花素注射液治疗.比较两组患者的临床疗效、治疗前后的细胞免疫、红细胞免疫与体液免疫指标.结果 观察组总有效率显著高于对照组(P<0.05).治疗前两组患者细胞免疫、红细胞免疫与体液免疫指标比较差异均无统计学意义(P>0.05);治疗后两组均较治疗前显著改善(P<0.05),观察组显著优于对照组(P<0.05).结论 灯盏花素注射液对急性心肌梗死患者细胞免疫、红细胞免疫及体液免疫的影响更为积极,对于综合免疫状态的调节作用突出,应用价值较高.

目的 探讨静脉注射尼可地尔联合常规治疗对急性心力衰竭(AHF)的疗效与安全性.方法 选取AHF患者128例,根据治疗方法不同分为尼可地尔组63例和对照组65例.两组均进行强心利尿、扩血管减轻心脏前负荷等常规治疗,尼可地尔组在常规治疗基础上加用尼可地尔静注,5 min内注射0.2 mg/kg,然后以0.2 mg/(kg· h)维持注射24 h.观察两组治疗过程中不良反应发生情况,采用超声心动图评价两组患者治疗前后的心功能变化,采用李克特5分量表法评价两组患者呼吸困难改善程度,比较两组患者3个月全因病死率和再入院率.结果 治疗过程中,两组均无严重不良反应.治疗6 h时尼可地尔组李克特量表评分低于对照组(P<0.05),1 h和6 h尼可地尔组李克特量评分较治疗前改善程度优于对照组(P均<0.05).尼可地尔组在1 h时二尖瓣血流速度值低于对照组(P<0.05),在1 h和24 h时二尖瓣血流速度与舒张早期二尖瓣环运动速度的比值较治疗前改善程度高于对照组(P均<0.05).尼可地尔组与对照组各有3例与2例患者失访,随访率95.31%.尼可地尔组与对照组3个月全因病死率[3.33%(2/60)vs 6.35%(4/63)]及再住院率[8.33%(5/60)vs 9.68%(6/63)]比较差异均无统计学意义(P均>0.05).结论 尼可地尔静脉注射联合常规治疗可改善急性心力衰竭患者呼吸困难及左室舒张功能,治疗过程中安全性良好,但不会改善患者3个月临床预后.

目的 探讨血清炎性指标和脂类指标在冠状动脉粥样硬化性心脏病患者中随病情进展水平及关系.方法 收集南阳市中心医院2013年3月-2017年3月收治的334例冠状动脉粥样硬化性心脏病患者,根据冠状动脉SYNTAX评分分为高危组87例、中危组115例,低危组132例.采用酶联免疫吸附法检测MCP-1、RANTES、CTRP1、ox-LDL水平,循环酶法检测HCY水平,免疫透射比浊法检测Lp(α)水平,分析冠状动脉粥样硬化性心脏病患者血清炎性指标与血脂指标水平变化及相关性.结果 冠状动脉粥样硬化性心脏病高危组血清MCP-1、RANTES、CTRP1水平明显高于中危组和低危组(P＜0.05);中危组血清MCP-1、RANTES、CTRP1水平高于低危组(P＜0.05).冠状动脉粥样硬化性心脏病高危组血清Lp(α)、HCY、ox-LDL水平明显高于中危组和低危组(P＜0.05);中危组血清Lp(α)、HCY、ox-LDL水平高于低危组(P＜0.05).经Pearson检验,血清MCP-1、RANTES、CTRP1水平与血清Lp(α)、HCY、ox-LDL水平呈显著相关性(P＜0.05).结论 血清新型炎性指标和脂类指标在冠状动脉粥样硬化性心脏病患者中随病情进展水平不断升高,两者间呈显著相关性,对冠状动脉粥样硬化性心脏病危险程度判断具有一定的指导意义.

Objective To assess the trends in clinical characteristics, management and outcomes for in-hospital patients with acute ST-segment elevation myocardial infarction (STEMI) of Nanyang Central Hospital from 2001 to 2016. Methods Acute myocardial infarction(AMI) patients who were admitted in Nanyang Central Hospital in 2001, 2006, 2011 and 2016 were randomly selected. We analyzed patients' clinical characteristics, management and outcomes of STEMI. Results 758 AMI patients including 558 STEMI were enrolled. From 2001 to 2016, the risk factors for cardiovascular disease such as hypertension, dyslipidemia and smoking substantially increased (P<0.05). The median onset time to admission shortened from 24 h to 12 h (P<0.0001). The proportion of patients who did not receive reperfusion did not change significantly, 38.9% in 2001, 16.7% in 2006, 35.7% in 2011, 38.4% in 2016 (P=0.34). The rate of primary PCI application increased from 0% to 39.4% (P<0.002). Administration of aspirin within 24h increased from 79.2% to 96.9% (P<0.001). Administration of clopidogrel/ticagrelor increased from 0 to 96.9% (P<0.001). Administration of statins increased from 0 to 96.6% (P<0.0001). Administration of β-blockers increased from 52.1% to 72.4% (P<0.001), but the application of ACEI/ARB decreased from 54.9% to 43.3% (P<0.002). In 2001,2006,2011 and 2016, The in-hospital mortalities were 8%, 10.2%, 9.2% and 7.1% (P=0.76), and the rates of death or treatment withdrawal because of terminal status were 2%,6.1%,7.3% and 8.1% (P=0.53). Conclusion The quality of medical care for STEMI was improved in the hospital from 2001 to 2016, while there were still obvious gaps from the guideline. The outcomes had not change significantly.

冠心病 (CHD) 高发于中老年人群, 且易并发心律失常等疾病, CHD患者在并发心律失常后, 若得不到有效控制则可诱发恶性心血管疾病, 严重影响患者生命健康[1].然而传统西药治疗心律失常在抑制早搏时具有一定负性传导反应, 长期治疗效果不理想, 故临床现开始尝试使用中西医结合方式以提高抗心律失常疗效, 均取得较好效果[2].基于此, 本研究选取郑州大学附属南阳医院收治的104例CHD心律失常患者为研究对象, 旨在探讨参松养心胶囊联合索他洛尔对CHD心律失常患者的治疗效果及对其QT离散度 (QTd) 和血管内皮功能的影响, 现报告如下:

Objective To investigate the effect of hypertension on major adverse cardiac events (MACE)in patients with ST-segment elevation myocardial infarction(STEMI).Methods According to with hypertension or not,217 patients with STEMI admitted to our hospital in 2001,2006 and 2011 were divided into hypertension group(73 cases)and non-hypertension group(144 cases).The incidences of MACE were compared between hypertension group and non-hypertension group.The incidences of MACE and the use of antihypertensive drugs on admission were compared among patients in hypertension group in 2001,2006 and 2011.Results The incidences of total MACE,unstable angina pectoris,heart failure and death of patients in hypertension group were significantly higher than those in non-hypertension group (P<0.05),but there was no significant difference in the incidence of recurrent myocardial infarction between two groups(P >0.05). The incidences of total MACE,in-hospital heart failure,proportion of patients who used angiotensin converting enzyme inhibitors(ACEI)/angiotensin Ⅱ receptor antagonists (ARB)and β-receptor blockers on admission were significantly different between 2001,2006 and 2011 in hypertension group(P<0.05).From 2001 to 2011,the incidence of heart failure in hypertension group showed a downward trend,while the proportions of patients who used ACEI/ARB and β-receptor blockers on admission showed an upward trend.There were no significant differences in incidences of unstable angina pectoris,recurrent myocardial infarction,death,proportions of patients who used diuretics and calcium antagonists on admission in hypertension group among 2001,2006 and 2011(P>0.05).Conclusion Hypertension increases the incidence of in-hospital MACE of STEMI patients.From 2001 to 2011,the rates in using ACEI/ARB and β-receptor blockers in STEMI patients with hypertension in our hospital show a upward trend,while the incidence of heart failure showes an downward trend.

目的 探讨H型高血压病人血浆超敏C-反应蛋白(hs-CRP)、白介素-6(IL-6)水平与颈动脉粥样硬化的关系及临床意义.方法 选择192例高血压病病人,根据血浆同型半胱氨酸(Hcy)水平分为H型高血压组131例和单纯高血压组61例,选择30名健康体检者作为健康对照组.测定血浆hs-CRP、IL-6、Hcy水平和颈动脉内膜中层厚度(IMT).结果 与健康对照组比较,H型高血压组和单纯高血压组病人血浆hs-CRP、IL-6、Hcy水平及IMT均显著增加(P＜0.05);与单纯高血压组比较,H型高血压组病人血浆中hs-CRP、IL-6、Hcy水平及IMT显著增加(P＜0.05).结论 H型高血压病人颈动脉粥样硬化与炎性反应、血管内皮功能受损密切相关.

目的 分析应用有创机械通气与无创机械通气治疗的心源性休克(CS)患者的临床特征与预后.方法 纳入在我院心内科重症监护室(intensive care unit,ICU)住院治疗的386例CS患者.根据患者转入ICU 24 h内通气支持的方式不同,将患者分为3组:有创机械通气组(n=241)、无创机械通气组(n=52)与补氧组(n=93).比较有创机械通气组与无创机械通气组患者的临床特征、治疗方法和预后.结果 有创机械通气组更易发生谵妄[200(83.0％) vs.16(30.8％),x2 =60.199,P ＜0.001],动脉血乳酸水平更高[3.9(2.4,7.1)mmol/L vs.1.9(1.6,2.8) mmol/L,U=13.700,P＜0.001],代谢性酸中毒更严重(HCO3指标更低)[19.7(15.8,21.6)mmol/L vs.22.1 (20.6,24.1) mmol/L,U=3.134,P=0.002],提示接受有创机械通气治疗的患者存在较严重的组织低灌注和休克.无创机械通气组患者具有更高的N端前脑钠肽水平[7376.8(2054.6,17373.7) pg/mL vs.2368.3(558.2,8564.7) pg/mL,U=2.261,P=0.023],提示接受无创机械通气治疗的患者可能存在心室扩张和充盈压增高.两组患者的90 d累计病死率比较差异无统计学意义(Log rank P=0.163).多变量Logistic回归分析显示,患者90d死亡的独立相关因素为:谵妄、冠状动脉搭桥手术、急性冠状动脉综合征、动脉血乳酸与动脉血二氧化碳分压(PaO2)(均P ＜0.05).通气方式与患者90 d死亡无相关性(P =0.856).结论 CS患者可使用无创机械通气治疗呼吸衰竭,通气方式与患者预后无关.

Objective:To investigate the effects of Ginsenoside Rg1 on arrhythmias following ischemic/reperfusion injury in rats and the related mechanism.Method:The myocardial ischemia/reperfusion injury model rats were divided into sham-operated group (SO group),ischemia/reperfusion group (I/R group),Ginsenoside Rg1 with low dose group (Rg3-L,20 mg · kg-1 · d-1,ip),Ginsenoside Rg1 with high dose group (Rg3-H,40 mg ·kg-1 · d-1,ip) and metroprolol succinate group (MS group,20 mg · kg-1 · d-1,ip).The severity of arrhythmia was judged by arrhythmias scores and the myocardial infarction area was investigated by TTC staining method.The mRNA expressions of Bax and Bcl-2 were determined by qPCR.The expressions of Cleaved-PARP,Cleaved-caspase-9 and Cleaved-caspase-3 were determined by Western blot.Result:There were occasional occurrences of premature ventricular contraction (PVC) and ventricular tachycardia (VT) in SO,Rg1-L,Rg1-H and MS group,while frequent occurrences of PVC,VT and ventricular fibrillation (VF) in I/R group.The ischemic arrhythmia score in SO,I/R,Rg1-L,Rg1-H and MS group was 0.37,4.2,1.9,0.46 and 0.42,respectively.TTC stating showed that,the myocardial infarct size in I/R group was obviously increased compared with SO group,while obviously decreased in Rg1-L,Rg1-H and MS group compared with I/R group (all P＜0.05).Compared with I/R group,the expression levels of Bcl-2 mRNA increased while Bax mRNA,Cleaved-PARP,Cleaved-caspase-9 Cleaved-caspase-3 protein decreased in Rg1-L and Rg1-H group,the phenomenon was more obvious in Rg1-H group.Conclusion:Ginsenoside Rg1 could significantly improve the occurrence ratio of arrhythmias and the myocardial infarct size after ischemia/reperfusion injury,the mechanism may be related to the regulation of regulate endogenous mitochondrial apoptosis pathway.

Objective:To investigate the quality of life of patients with anxiety and depression state after percutaneous coronary interventional (PCI) and the impact of Yixinshu capsules.Methods:A total of 1 367 patients with PCI operation were selected from Nanyang Central Hospital from January 2014 to August 2015.According to Self-Rating Depression Scale (SDS) and Self-Rating Anxiety Scale (SAS),anxiety were found in 287 patients,depression in 256 patients,and anxiety and depression in 183 cases.The patients with anxiety and depression were divided into the experimental and control groups.The control group received conventional treatment,and the experimental group received Yixinshu capsules three times a day in addition to the conventional treatment.The therapeutic effects of Yixinshu capsules on the quality of life and incidence of anxiety and depression and the adverse reactions were observed.Results:The baseline data,quality of life,HAMA score,and HRSP score before treatment had no significant difference between the two groups.After 1 month of therapy,the score of quality of life in the experimental group had significant (P ＜ 0.05) or extremely significant (P ＜ 0.01) difference compared with the control group;the HAMA scores and HRSP score were significantly lower than the control group (P ＜ 0.05).After 3 months of treatment,the scores of quality of life,HAMA scores,and HRSP scores had extremely significant difference between the two groups (P ＜ 0.01).Conclusion:A high incidence of anxiety and depression exists after PCI.Yixinshu capsules can relieve anxiety and depression and improve the quality of life of the patients.

Objective To evaluate the effects of Xinmailong injection (XMLI) on cardiac function and plasma N-terminal-pro B type natriuretic peptide (NT-proBNP) levels in patients with coronary heart disease with chronic heart failure (CHF).Methods One hundred and sixteen patients admitted to the departments of cardiology of Nanyang city central Hospital from 2015 to 2016 were selected and randomly divided into two groups:control group(n=58) treated with routine treatment,and treatment group (n=58) treated with XMLI and routine treatment for 14 days.The cardiac function,6 minutes walking test,left ventricular diastolic dysfunction(LVDd),left ventricular ejection fraction(LVEF) and plasma NT-proBNP were detected in the two groups before and after treatment.Results After treatment,the 6 minutes distance,LVDd,LVEF improved in two groups(P＜0.05).The 6 minutes distance,LVDd,LVEF improved degree of treatment group were higher than that in control group(P＜0.05).Plasma NT-proBNP level was reduced in two groups(P＜0.05),which was lower in treatment group than that in control group(P＜0.05).Conclusion XMLI can improve cardiac function and reduce the level of plasma NT-pro BNP in patients with CHF.

目的 评价2001~2011年辽宁省急性心肌梗死(AMI)住院患者他汀使用情况及其影响因素.方法 调查辽宁省7家协作医院2001、2006和2011 3个特定年份研究病历,以提取临床信息.结果 7家医院共计1 284例适宜他汀治疗的AMI患者病历纳入研究.AMI患者院内他汀的使用率从2001年的43.18%增加到2006年的93.44%和2011年的96.22%(P<0.000 1).不同低密度脂蛋白胆固醇(LDL-C)水平患者他汀使用率均逐年增加(均P<0.05).未检测LDL-C患者他汀使用率显著低于LDL-C检测的患者(P<0.000 1).院内强化他汀的使用率由2001年的1.75%增加到2006年的25.96%和2011年的57.99%(P<0.000 1).多因素模型中,高脂血症患者更容易接受他汀治疗(OR=1.53,95%CI 1.09~2.13,P=0.013).接受经皮冠状动脉介入(PCI)患者较非PCI患者更容易接受他汀治疗(OR=2.70,95%CI 1.99~3.66,P<0.001).心源性休克患者他汀治疗率明显降低(OR=0.43,95%CI 0.20~0.93,P=0.033).结论 2001~2011年辽宁省AMI患者他汀类药物应用率明显增加,但2011年仍然有超过40%患者未接受强化他汀治疗.

Objective:To investigate the combination therapeutic effect of sitagliptin and ezetimibe on atherosclerosis in apoE-/-mice and explore the related mechanisms.Methods:T-he 6-week apoE / mice were randomly divided into 5 groups:normal group,high-fat diet group,Sitagliptin group,Ezetimibe group,and combination therapy group.The levels of blood glucose and lipid were detected by biochemical detector.Atherosclerotic plaque area in aortas were measured by oil red O staining.The concentration of vascular cell adhesion molecule-1 (VCAM-1),monocyte chemoattractant protein-1 (MCP-1) and TNF-α in serum were determined by ELISA assay.The expressions of NF-κB p65 were analyzed by Western blot.Results:Compared to sitagliptin or ezetimibe,combination therapy group can further inhibited high-fat diet-induced the increase of total cholesterol (TC) and low density lipoprotein cholesterin (LDL-C) levels (P＜0.05),while increased the level of high density lipoprotein cholesterol (HDL-C) (P＜0.05).Moreover,the inhibition of atherosclerotic plaque formation,VCAM-1,MCP-1 and TNF-α concentration,and NF-κB p65 protein expression were more much pronounced in combination therapy group (P＜0.05).Conclusion:Our data demonstrates that combination of sitagliptin and ezetimibe can further inhibit the atherosclerotic plaque formation and prevent atherosclerosis in apoE-/-mice,which may through activation of NF-κB signaling pathway.

Objective: To investigate the patients′ state of anxiety-depression symptom and quality of life after acute myocardial infarction and the influence of Yixinshu Capsule on patients.Methods: Five hundred and seventeen patients with acute myocardial infarction were included from Nanyang Central Hospital from January 2014 to December 2015. Based on Self-Rating Depression Scale (SDS) and Self-Rating Anxiety Scale (SAS), 102 patients with anxiety, 89 patients with depression, and 63 patients with anxiety and depression were selected.Patients with both anxiety and depression were randomly divided into the experimental and control group.Patients in the control group received conventional treatment, while patients in the experimental group additionally received Yixinshu Capsule.The therapeutic effects and adverse reactions and the impact on patients′ quality of life and incidence of anxiety and depression were observed.Results: The baseline data no significant difference between two groups (P>0.05), Quality of life and HAMA score, HRSP score before treatment no significant difference (P>0.05).After one-month′s treatment, the quality of life of the treatment group showed significant difference compared with that of the control group (P<0.05, P<0.01);HAMA scores and HRSP score of the treatment group was significantly lower than those of the control group (P<0.05).After 3 months′ treatment, scores for quality of life, HAMA scores and HRSP scores showed remarkably significant difference between the two groups (P<0.01).Conclusion: Yixinshu Capsule may relieve anxiety and depression and improve quality of life in patients with acute myocardial infarction.

Objective To analyze the trend of drug use for inpatients with acute myocardial infarction (AMI) from 2001 to 2011,in order to provide reference for the rational use of drags.Methods The medical records of inpatients in the year 2001,2006 and 2011 were reviewed.The uses of aspirin,clopidogrel,stain,β blocker and angiotensin-converting-enzyme inhibitors (ACEI)/angiotensin receptor blockers (ARB) were assessed.Results A total of 234 cases were enrolled.There were significant increases in the use of aspirin (80.0％,86.0％,94.8％,P =0.013),clopidogrel (0％,50.9％,87.8％,P ＜0.001),and stain (34.0％,81.8％,95.6 ％,P ＜0.001) in 2001,2006 and 2011.The utilization rates of β blocker (51.1％,64.7 ％,56.4％,P =0.401) and ACEI/ARB (62.5 ％,72.2％,60.9％,P =0.262) were still relatively low,with no statistical difference in the past decade.Conclusion During the past decade,the uses of aspirin,clopidogrel and stain are significantly increased in Nanyang Central Hospital,but there is still gap between clinical practice and guideline in the uses of β blocker and ACEI/ARB.