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个人简介
Maria's research interests have been focused on studying the behaviour of progenitor cells in the mouse oesophagus as a model to unveil the basic rules underlying squamous epithelial cell fate. Her work in the field has revealed how this tissue is maintained under homeostatic conditions, and how these rules switch upon injury.
More recently she has been able to identify how progenitor cells alter and adapt their behaviour in response to preneoplastic mutations, reflecting their remarkable cellular plasticity. Investigating the cellular and molecular mechanisms governing this dynamic behaviour and the potential implications for early cancer development will constitute the basis of my research programme.
To answer these questions, she plans to make use of a combination of in vivo lineage tracing techniques, transcriptional network analysis, as well as 3D organoid and explant culture systems.
More recently she has been able to identify how progenitor cells alter and adapt their behaviour in response to preneoplastic mutations, reflecting their remarkable cellular plasticity. Investigating the cellular and molecular mechanisms governing this dynamic behaviour and the potential implications for early cancer development will constitute the basis of my research programme.
To answer these questions, she plans to make use of a combination of in vivo lineage tracing techniques, transcriptional network analysis, as well as 3D organoid and explant culture systems.
研究兴趣
论文共 31 篇作者统计合作学者相似作者
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Albert Herms,David Fernandez-Antoran,Maria P. Alcolea, Argyro Kalogeropoulou, Ujjwal Banerjee,Gabriel Piedrafita,Emilie Abby, Jose Antonio Valverde-Lopez, Inês S. Ferreira,Stefan C. Dentro,Swee Hoe Ong,Bartomeu Colom,
biorxiv(2023)
Maria T. Bejar, Paula Jimenez-Gomez,Ilias Moutsopoulos,Bartomeu Colom,Seungmin Han,Fernando J Calero-Nieto, Berthold Göttgens,Irina Mohorianu,Benjamin D. Simons,Maria P. Alcolea
biorxiv(2021)
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