基本信息
浏览量:2
职业迁徙
个人简介
We use baker’s yeast, Saccharomyces cerevisiae, as a model genetic organism in which to study the molecular mechanisms of stress signaling. The biomedical relevance of our work is two-fold. First, we seek to identify novel aspects of signal transduction that are evolutionarily conserved with humans and therefore tell us something about our own biology that may be useful in the treatment of disease. Second, when we identify aspects or components of signaling pathways that are unique to fungi, these often represent potential targets for antifungal drug discovery.
Our work centers on the molecular mechanisms involved in the activation and signaling output of two stress-activated MAP kinase (SAPK) pathways — the Cell Wall Integrity (CWI) pathway, which responds to cell wall challenges during growth and morphogenesis, and the High Osmolarity Glycerol (HOG) pathway, which responds to hyper-osmotic stress. We have found in recent studies that, like mammalian SAPK pathways, these two yeast pathways respond to a wide variety of stress conditions in addition to their well-understood functions in the maintenance of the cell wall and osmotic balance. These stresses include DNA damage, metal toxicity, oxidative stress, organic acid stress, and others. We are currently pursuing a very interesting pair of related questions. Specifically, what are the pathways by which such different types of stress stimulate the same SAPKs, and how does their stimulation by these diverse signals result in stress-specific signaling outputs?
研究兴趣
论文共 117 篇作者统计合作学者相似作者
按年份排序按引用量排序主题筛选期刊级别筛选合作者筛选合作机构筛选
时间
引用量
主题
期刊级别
合作者
合作机构
Paediatric anaesthesiano. 11 (2023): 938-945
Alexander Koven,Fardod O'Kelly,Ali El-Ghazzaoui,Jacob C Langer,David Levin, Aubie Diamond, Yisroel Goldstein, Ezriel Reichman,Martin A Koyle
加载更多
作者统计
合作学者
合作机构
D-Core
- 合作者
- 学生
- 导师
数据免责声明
页面数据均来自互联网公开来源、合作出版商和通过AI技术自动分析结果,我们不对页面数据的有效性、准确性、正确性、可靠性、完整性和及时性做出任何承诺和保证。若有疑问,可以通过电子邮件方式联系我们:report@aminer.cn