基本信息
浏览量:0
职业迁徙
个人简介
My scientific training was in the field of mitochondrial biochemistry in disease under the supervision of John Morgan-Hughes and John Clark (PhD 1987) at the Institute of Neurology, London. I characterisation the defects in patients with mitochondrial disorders which led to the identification of the first mtDNA deletions (Holt et al 1988, 1989),
In 1990 I was appointed as Lecturer in the Department of Protein and Molecular Biology at the Royal Free Hospital Medical School, and subsequently in 1994 as Senior Lecturer in the department of Clinical Neurosciences. In 2010 I was appointed as Reader in Neurodegenerative diseases in the department of Clinical Neurosciences UCL Institute of Neurology.
Mitochondrial function continued to play an important role in my research, studying Leber’s hereditary Optic Neuropathy (Cock et al 1995) and various other mtDNA mutations (Morten et al 1993) and demonstrated mtDNA depletion syndrome was a nuclear gene disorder (Bodnar et al 1993). I generated an in vivo model to recapitulate the biochemical phenotypes (Cooper et al 1988) and therapeutic evaluation (Cooper et al 1992).
Mitochondrial function in neurodegenerative diseases continues to play a larg part of my research covering ;PD (Schapira et al 1989), Alzheimer’s disease (Cooper et al 1993), HD (Gu et al 1996), Friedreich's ataxia (Bradley et al 2000), Wilson’s disease (Gu et al 2000), ageing (Cooper et al 1992) ;oxidative stress (Thomas et al 1993, Rafique et al 2001) and increased iron (Hartley et al 1993).
Friedreich’s Ataxia (FRDA) research made up a significant part of my work.We confirmed the role of mitochondrial dysfunction, iron accumulation (Bradley et al 2000) and oxidative damage (Bradley et al 2004) in patients with FRDA. Using 31P MRS in collaboration with Raphaele Lodi we were able to detect the mitochondrial ox phos defects in vivo in skeletal muscle (Lodi et al 1999) and cardiac muscle (Lodi et al 2001). We obtained extensive clinical data on over 70 FRDA patients involving neurological, cardiac (Rajagopalan et al 2010), speech and limb co-ordination evaluations and evaluation of quality of life and activities of daily living for the cross sectional analysis of the natural history of FRDA (Cooper et al 2008). Long term vitamin E and coenzyme Q10 therapy trials identified an improvement in mitochondrial function (Lodi et al 2001, Hart et al 2005) and clinical scores (Cooper et al 2008). We have evaluated the ICARS scale for the evaluation of FRDA (Cano et al 2005, Metz et al 2013) and generated a new validated patient scale – Friedreich’s Ataxia Impact Scale (FAIS) (Cano et al 2009). I have collaborated with Mark Pook in the analysis of a transgenic mouse model (Pook et al 2001, Al-Mahdawi et al 2006).
In 1990 I was appointed as Lecturer in the Department of Protein and Molecular Biology at the Royal Free Hospital Medical School, and subsequently in 1994 as Senior Lecturer in the department of Clinical Neurosciences. In 2010 I was appointed as Reader in Neurodegenerative diseases in the department of Clinical Neurosciences UCL Institute of Neurology.
Mitochondrial function continued to play an important role in my research, studying Leber’s hereditary Optic Neuropathy (Cock et al 1995) and various other mtDNA mutations (Morten et al 1993) and demonstrated mtDNA depletion syndrome was a nuclear gene disorder (Bodnar et al 1993). I generated an in vivo model to recapitulate the biochemical phenotypes (Cooper et al 1988) and therapeutic evaluation (Cooper et al 1992).
Mitochondrial function in neurodegenerative diseases continues to play a larg part of my research covering ;PD (Schapira et al 1989), Alzheimer’s disease (Cooper et al 1993), HD (Gu et al 1996), Friedreich's ataxia (Bradley et al 2000), Wilson’s disease (Gu et al 2000), ageing (Cooper et al 1992) ;oxidative stress (Thomas et al 1993, Rafique et al 2001) and increased iron (Hartley et al 1993).
Friedreich’s Ataxia (FRDA) research made up a significant part of my work.We confirmed the role of mitochondrial dysfunction, iron accumulation (Bradley et al 2000) and oxidative damage (Bradley et al 2004) in patients with FRDA. Using 31P MRS in collaboration with Raphaele Lodi we were able to detect the mitochondrial ox phos defects in vivo in skeletal muscle (Lodi et al 1999) and cardiac muscle (Lodi et al 2001). We obtained extensive clinical data on over 70 FRDA patients involving neurological, cardiac (Rajagopalan et al 2010), speech and limb co-ordination evaluations and evaluation of quality of life and activities of daily living for the cross sectional analysis of the natural history of FRDA (Cooper et al 2008). Long term vitamin E and coenzyme Q10 therapy trials identified an improvement in mitochondrial function (Lodi et al 2001, Hart et al 2005) and clinical scores (Cooper et al 2008). We have evaluated the ICARS scale for the evaluation of FRDA (Cano et al 2005, Metz et al 2013) and generated a new validated patient scale – Friedreich’s Ataxia Impact Scale (FAIS) (Cano et al 2009). I have collaborated with Mark Pook in the analysis of a transgenic mouse model (Pook et al 2001, Al-Mahdawi et al 2006).
研究兴趣
论文共 16 篇作者统计合作学者相似作者
按年份排序按引用量排序主题筛选期刊级别筛选合作者筛选合作机构筛选
时间
引用量
主题
期刊级别
合作者
合作机构
Food and chemical toxicology (2021): 112164-112164
Daniel J. Klionsky,Kotb Abdelmohsen, Akihisa Abe,Joynal Abedin,Hagai Abeliovich,Abraham Acevedo Arozena,Hiroaki Adachi,Christopher M. Adams,Peter D. Adams,Khosrow Adeli,Peter J. Adhihetty,Sharon G. Adler,Galila Agam,Rajesh Agarwal,Manish K. Aghi,Maria Agnello,Patrizia Agostinis,Patricia V. Aguilar,Julio Aguirre-Ghiso, Edoardo M. Airoldi,Slimane Ait-Si-Ali,Takahiko Akematsu,Emmanuel T. Akporiaye,Mohamed Al-Rubeai, Guillermo M. Albaiceta,Chris Albanese,Diego Albani,Matthew L. Albert,Jesus Aldudo,Hana Algül,Mehrdad Alirezaei,Iraide Alloza,Alexandru Almasan,Maylin Almonte-Beceril,Emad S. Alnemri,Covadonga Alonso,Nihal Altan-Bonnet,Dario C. Altieri,Silvia Alvarez,Lydia Alvarez-Erviti,Sandro Alves,Giuseppina Amadoro,Atsuo Amano,Consuelo Amantini,Santiago Ambrosio,Ivano Amelio,Amal O. Amer,Mohamed Amessou,Angelika Amon,Zhenyi An,Frank A. Anania,Stig U. Andersen,Usha P. Andley,Catherine K. Andreadi,Nathalie Andrieu-Abadie,Alberto Anel,David K. Ann,Shailendra Anoopkumar-Dukie,Manuela Antonioli,Hiroshi Aoki,Nadezda Apostolova,Saveria Aquila,Katia Aquilano,Koichi Araki,Eli Arama,Agustin Aranda,Jun Araya,Alexandre Arcaro,Esperanza Arias,Hirokazu Arimoto,Aileen R. Ariosa,Jane L. Armstrong,Thierry Arnould, Ivica Arsov,Katsuhiko Asanuma,Valerie Askanas,Eric Asselin,Ryuichiro Atarashi,Sally S. Atherton,Julie D. Atkin,Laura D. Attardi,Patrick Auberger,Georg Auburger,Laure Aurelian,Riccardo Autelli,Laura Avagliano,Maria Laura Avantaggiati, Limor Avrahami, Neelam Azad,Suresh Awale,Tiziana Bachetti,Jonathan M. Backer,Dong Hun Bae, Jae Sung Bae,Ok Nam Bae,Soo Han Bae,Eric H. Baehrecke,Seung Hoon Baek,Stephen Baghdiguian,Agnieszka Bagniewska-Zadworna,Hua Bai,Jie Bai,Xue Yuan Bai,Yannick Bailly, Kithiganahalli Narayanaswamy Balaji,Walter Balduini,Andrea Ballabio,Rena Balzan,Rajkumar Banerjee,Gábor Bánhegyi,Haijun Bao,Benoit Barbeau,Maria D. Barrachina,Esther Barreiro,Bonnie Bartel, Alberto Bartolomé,Diane C. Bassham,Maria Teresa Bassi, Robert C. Bast,Alakananda Basu,Maria Teresa Batista,Henri Batoko,Maurizio Battino, Kyle Bauckman,Bradley L. Baumgarner,K. Ulrich Bayer,Rupert Beale,Jean François Beaulieu, George R. Beck,Christoph Becker, J. David Beckham, Pierre André Bédard,Patrick J. Bednarski,Thomas J. Begley,Christian Behl,Christian Behrends,Georg M.N. Behrens,Kevin E. Behrns,Eloy Bejarano,Amine Belaid,Francesca Belleudi,Giovanni Bénard,Guy Berchem,Daniele Bergamaschi,Matteo Bergami,Ben Berkhout,Laura Berliocchi,Amélie Bernard,Monique Bernard,Francesca Bernassola,Anne Bertolotti, Amanda S. Bess,Sébastien Besteiro,Saverio Bettuzzi,Savita Bhalla,Shalmoli Bhattacharyya,Sujit K. Bhutia, Caroline Biagosch,Michele Wolfe Bianchi,Martine Biard-Piechaczyk,Viktor Billes,Claudia Bincoletto,Baris Bingol,Sara W. Bird,Marc Bitoun,Ivana Bjedov,Craig Blackstone,Lionel Blanc, Guillermo A. Blanco,Heidi Kiil Blomhoff,Emilio Boada-Romero, Stefan Böckler,Marianne Boes,Kathleen Boesze-Battaglia,Lawrence H. Boise, Alessandra Bolino,Andrea Boman,Paolo Bonaldo,Matteo Bordi,Jürgen Bosch,Luis M. Botana,Joelle Botti,German Bou,Marina Bouché,Marion Bouchecareilh,Marie Josée Boucher,Michael E. Boulton,Sebastien G. Bouret,Patricia Boya,Michaël Boyer-Guittaut,Peter V. Bozhkov,Nathan Brady,Vania M.M. Braga,Claudio Brancolini,Gerhard H. Braus, José M. Bravo-San-Pedro,Lisa A. Brennan,Emery H. Bresnick,Patrick Brest,Dave Bridges,Marie Agnès Bringer,Marisa Brini, Glauber C. Brito,Bertha Brodin,Paul S. Brookes,Eric J. Brown,Karen Brown,Hal E. Broxmeyer,Alain Bruhat,Patricia Chakur Brum,John H. Brumell,Nicola Brunetti-Pierri,Robert J. Bryson-Richardson,Shilpa Buch,Alastair M. Buchan,Hikmet Budak,Dmitry V. Bulavin,Scott J. Bultman,Geert Bultynck, Vladimir Bumbasirevic,Yan Burelle,Robert E. Burke,Margit Burmeister,Peter Bütikofer,Laura Caberlotto,Ken Cadwell,Monika Cahova,Dongsheng Cai,Jingjing Cai,Qian Cai,Sara Calatayud,Nadine Camougrand,Michelangelo Campanella, Grant R. Campbell,Matthew Campbell,Silvia Campello,Robin Candau,Isabella Caniggia, Lavinia Cantoni,Lizhi Cao,Allan B. Caplan,Michele Caraglia,Claudio Cardinali,Sandra Morais Cardoso,Jennifer S. Carew,Laura A. Carleton,Cathleen R. Carlin,Silvia Carloni,Sven R. Carlsson,Didac Carmona-Gutierrez,Leticia A.M. Carneiro,Oliana Carnevali,Serena Carra,Alice Carrier,Bernadette Carroll,Caty Casas,Josefina Casas,Giuliana Cassinelli,Perrine Castets,Susana Castro-Obregon,Gabriella Cavallini,Isabella Ceccherini,Francesco Cecconi,Arthur I. Cederbaum,Valentín Ceña,Simone Cenci,Claudia Cerella,Davide Cervia,Silvia Cetrullo,Hassan Chaachouay, Han Jung Chae,Andrei S. Chagin, Chee Yin Chai, Gopal Chakrabarti,Georgios Chamilos,Edmond Y.W. Chan, Matthew T.V. Chan,Dhyan Chandra, Pallavi Chandra,Chih Peng Chang,Raymond Chuen Chung Chang,Ta Yuan Chang,John C. Chatham,Saurabh Chatterjee,Santosh Chauhan,Yongsheng Che,Michael E. Cheetham,Rajkumar Cheluvappa,Chun Jung Chen,Gang Chen,Guang Chao Chen,Guoqiang Chen,Hongzhuan Chen,Jeff W. Chen,Jiankang Chen,Min Chen,Mingzhou Chen,Peiwen Chen,Qi Chen,Quan Chen, Shang Der Chen,Si Chen,Steve S.L. Chen,Wei Chen, Wei Jung Chen,Wen Qiang Chen,Wenli Chen,Xiangmei Chen, Yau Hung Chen,Ye Guang Chen,Yin Chen,Yingyu Chen,Yongshun Chen,Yu Jen Chen,Yue Qin Chen,Yujie Chen,Zhen Chen,Zhong Chen,Alan Cheng, Christopher H.K. Cheng,Hua Cheng,Heesun Cheong,Sara Cherry,Jason Chesney,Chun Hei Antonio Cheung,Eric Chevet, Hsiang Cheng Chi,Sung Gil Chi,Fulvio Chiacchiera, Hui Ling Chiang,Roberto Chiarelli,Mario Chiariello,Marcello Chieppa,Lih Shen Chin,Mario Chiong, Gigi N.C. Chiu,Dong Hyung Cho,Ssang Goo Cho,William C. Cho, Yong Yeon Cho,Young Seok Cho, Augustine M.K. Choi,Eui Ju Choi,Eun Kyoung Choi,Jayoung Choi,Mary E. Choi,Seung Il Choi,Tsui Fen Chou,Salem Chouaib,Divaker Choubey,Vinay Choubey, Kuan Chih Chow,Kamal Chowdhury,Charleen T. Chu, Tsung Hsien Chuang,Taehoon Chun,Hyewon Chung,Taijoon Chung,Yuen Li Chung, Yong Joon Chwae,Valentina Cianfanelli,Roberto Ciarcia,Iwona A. Ciechomska,Maria Rosa Ciriolo,Mara Cirone,Sofie Claerhout,Michael J. Clague, Joan Cl ria,Peter G.H. Clarke,Robert Clarke,Emilio Clementi,Cédric Cleyrat,Miriam Cnop,Eliana M. Coccia,Tiziana Cocco,Patrice Codogno,Jörn Coers,Ezra E.W. Cohen,David Colecchia,Luisa Coletto,Núria S. Coll,Emma Colucci-Guyon,Sergio Comincini,Maria Condello,Katherine L. Cook,Graham H. Coombs, Cynthia D. Cooper,J. Mark Cooper,Isabelle Coppens,Maria Tiziana Corasaniti,Marco Corazzari,Ramon Corbalan,Elisabeth Corcelle-Termeau,Mario D. Cordero,Cristina Corral-Ramos,Olga Corti,Andrea Cossarizza,Paola Costelli,Safia Costes,Susan L. Cotman,Ana Coto-Montes, Sandra Cottet,Eduardo Couve,Lori R. Covey,L. Ashley Cowart,Jeffery S. Cox,Fraser P. Coxon,Carolyn B. Coyne,Mark S. Cragg, Rolf J. Craven,Tiziana Crepaldi,Jose L. Crespo,Alfredo Criollo,Valeria Crippa,Maria Teresa Cruz,Ana Maria Cuervo,Jose M. Cuezva,Taixing Cui,Pedro R. Cutillas,Mark J. Czaja,Maria F. Czyzyk-Krzeska,Ruben K. Dagda,Uta Dahmen,Chunsun Dai,Wenjie Dai,Yun Dai,Kevin N. Dalby,Luisa Dalla Valle,Guillaume Dalmasso,Marcello D'amelio,Markus Damme,Arlette Darfeuille-Michaud,Catherine Dargemont,Victor M. Darley-Usmar,Srinivasan Dasarathy,Biplab Dasgupta,Srikanta Dash,Crispin R. Dass,Hazel Marie Davey,Lester M. Davids,David Dávila,Roger J. Davis,Ted M. Dawson,Valina L. Dawson,Paula Daza,Jackie de Belleroche,Paul de Figueiredo,Regina Celia Bressan Queiroz de Figueiredo,José de la Fuente,Luisa De Martino,Antonella De Matteis,Guido R.Y. De Meyer,Angelo De Milito,Mauro De Santi,Wanderley de Souza,Vincenzo De Tata,Daniela De Zio,Jayanta Debnath,Reinhard Dechant,Jean Paul Decuypere,Shane Deegan,Benjamin Dehay, Barbara Del Bello,Dominic P. Del Re,Régis Delage-Mourroux,Lea M.D. Delbridge,Louise Deldicque,Elizabeth Delorme-Axford,Yizhen Deng,Joern Dengjel,Melanie Denizot,Paul Dent,Channing J. Der,Vojo Deretic,Benoît Derrien, Eric Deutsch,Timothy P. Devarenne,Rodney J. Devenish,Sabrina Di Bartolomeo,Nicola Di Daniele,Fabio Di Domenico,Alessia Di Nardo,Simone Di Paola,Antonio Di Pietro,Livia Di Renzo, Aaron Di Antonio,Guillermo Díaz-Araya,Ines Díaz-Laviada,Maria T. Diaz-Meco, Javier Diaz-Nido,Chad A. Dickey,Robert C. Dickson,Marc Diederich
user-5ebe282a4c775eda72abcdce(2016)
引用27浏览0引用
27
0
Michael W.J. Cleeter,Kai-Yin Chau, Caroline Gluck,Atul Mehta,Derralynn A. Hughes,Michael Duchen,Nicholas William Wood,John Hardy,J. Mark Cooper,Anthony Henry Schapira
Miriam Cnop,Mariana Igoillo-Esteve,Myriam Rai, Audrey Begu,Yasmina Serroukh,Chantal Depondt,Anyishai E Musuaya,Ihsane Marhfour,Laurence Ladrière,Xavier Moles Lopez, Dionysios Lefkaditis,Fabrice Moore,Jean-Pierre Brion,J Mark Cooper,Anthony H V Schapira,Anne Clark,Arnulf H Koeppen,Piero Marchetti,Massimo Pandolfo,Décio L Eizirik,Françoise Féry
semanticscholar(2009)
引用0浏览0引用
0
0
加载更多
作者统计
#Papers: 17
#Citation: 1058
H-Index: 13
G-Index: 15
Sociability: 6
Diversity: 2
Activity: 2
合作学者
合作机构
D-Core
- 合作者
- 学生
- 导师
数据免责声明
页面数据均来自互联网公开来源、合作出版商和通过AI技术自动分析结果,我们不对页面数据的有效性、准确性、正确性、可靠性、完整性和及时性做出任何承诺和保证。若有疑问,可以通过电子邮件方式联系我们:report@aminer.cn