基本信息
浏览量:2
职业迁徙
个人简介
Dr. Pisegna’s main research interest is the molecular pharmacology of hormones and receptors in the gastrointestinal tract. These research and clinical interests derive from research in the biochemistry and molecular physiology of neuroendocrine tumors as well as an understanding of the molecular interaction of peptide hormones and their receptors. His clinical efforts are currently focused on the management of gastric hypersecretory conditions, neuroendocrine tumors of the GI tract, and Zollinger Ellison Syndrome (ZES), medical conditions that derive from alterations in the expression of gastrointestinal hormones. Dr. Pisegna cloned the receptor for human cholecystokinin A (CCKA), the cholecystokinin B (CCKB or gastrin) receptor and the pituitary adenylate cyclase activating polypeptide (PACAP) receptor. He has previously demonstrated that PACAP is a potent stimulant of gastric acid secretion and is expressed on neurons innervating the stomach, on enterochromaffin-like cells (ECL) of the stomach expressing receptors for PACAP. Using mice lacking the PAC1 receptor, he has demonstrated that the mice develop a gastric acid hypersecretory condition resulting from hypergastrinemia. Recently his lab is focused on understanding the role of peptide hormones in the development of obesity, metabolic syndrome and NAFLD. Dr. Pisegna's research interests extend to understanding the molecular mechanisms involved in satiety and metabolic syndrome including the role of the gastrointestinal microbiome.
研究兴趣
论文共 136 篇作者统计合作学者相似作者
按年份排序按引用量排序主题筛选期刊级别筛选合作者筛选合作机构筛选
时间
引用量
主题
期刊级别
合作者
合作机构
Simer Shera, David Zhang, Shrey Pawar, Madelaine Leitman,Claudia P. Sanmiguel,Erik Dutson,Arpan A. Patel,Julianne C. Yang,Candace Chang,Emeran A. Mayer,Joseph R. Pisegna,Jihane N. Benhammou,
Gastroenterologyno. 5 (2024): S-1570
American journal of physiology. Gastrointestinal and liver physiologyno. 3 (2023): G239-G250
Gastro Hep Advancesno. 2 (2023): 232-241
引用0浏览0WOS引用
0
0
eBioMedicine (2023): 104620-104620
引用0浏览0WOS引用
0
0
AMERICAN JOURNAL OF GASTROENTEROLOGYno. 12 (2023): 2144-2145
加载更多
作者统计
合作学者
合作机构
D-Core
- 合作者
- 学生
- 导师
数据免责声明
页面数据均来自互联网公开来源、合作出版商和通过AI技术自动分析结果,我们不对页面数据的有效性、准确性、正确性、可靠性、完整性和及时性做出任何承诺和保证。若有疑问,可以通过电子邮件方式联系我们:report@aminer.cn