基本信息
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职业迁徙
个人简介
My Research
KEYWORDS
molecular, cellular & translational neuroscience, synaptic physiology, channels and transporters
SUMMARY
My laboratory studies synaptic mechanisms underlying the control of movement. Our goal is to reveal how the nervous system generates movement and how disorders of movement control—such as Parkinson’s disease—corrupt this process.
I am particularly interested in understanding how a collection of brain nuclei known as the basal ganglia (BG) participates in the selection, execution, and reinforcement of voluntary movement at the level of synapses, cells, and circuits. The BG have been extensively implicated in the control of movement both clinically and experimentally, but the precise neural mechanisms by which goal-directed movement is enabled and learned remain poorly understood.
Our current studies focus on how dopamine-releasing neurons, which play a critical role in the function and plasticity of motor circuits, modulate the activity of target neurons within the BG. We have shown that synaptic transmission from dopaminergic neurons is more complex than previously thought, extending beyond the sole release of dopamine.
Specifically, we found that dopaminergic neurons silence striatal projection neurons by co-releasing the inhibitory neurotransmitter gamma-aminobutyric acid, or GABA, and that they modulate the activity of striatal cholinergic interneurons by co-releasing dopamine and another neurotransmitter.
KEYWORDS
molecular, cellular & translational neuroscience, synaptic physiology, channels and transporters
SUMMARY
My laboratory studies synaptic mechanisms underlying the control of movement. Our goal is to reveal how the nervous system generates movement and how disorders of movement control—such as Parkinson’s disease—corrupt this process.
I am particularly interested in understanding how a collection of brain nuclei known as the basal ganglia (BG) participates in the selection, execution, and reinforcement of voluntary movement at the level of synapses, cells, and circuits. The BG have been extensively implicated in the control of movement both clinically and experimentally, but the precise neural mechanisms by which goal-directed movement is enabled and learned remain poorly understood.
Our current studies focus on how dopamine-releasing neurons, which play a critical role in the function and plasticity of motor circuits, modulate the activity of target neurons within the BG. We have shown that synaptic transmission from dopaminergic neurons is more complex than previously thought, extending beyond the sole release of dopamine.
Specifically, we found that dopaminergic neurons silence striatal projection neurons by co-releasing the inhibitory neurotransmitter gamma-aminobutyric acid, or GABA, and that they modulate the activity of striatal cholinergic interneurons by co-releasing dopamine and another neurotransmitter.
研究兴趣
论文共 36 篇作者统计合作学者相似作者
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Cell reportsno. 3 (2024): 113834-113834
Cell reportsno. 8 (2023): 112901-112901
Nature communicationsno. 1 (2023)
bioRxiv (Cold Spring Harbor Laboratory) (2022)
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作者统计
#Papers: 36
#Citation: 3630
H-Index: 19
G-Index: 28
Sociability: 5
Diversity: 2
Activity: 27
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