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个人简介
I am a Ph.D. student, currently working in the Department of Pediatric Endocrinology, Diabetology and Metabolism, University's Children Hospital, Bern Switzerland.
My research topic involves Identification and Targeting of Novel Mechanisms for the Treatment of Castration-Resistant Prostate Cancer (CRPC). High levels of circulating Androgens are linked to CRPC and Polycystic Ovary Syndrome (PCOS). An enzyme, Cytochrome P450 c17 (CYP17A1) plays an important role in the production of Androgen and its precursors through its 17,20 Lyase activity in the human steroidogenic pathway. Prostate cancer (PCa) is driven in parts by its responsiveness to androgens, CYP17A1 is a major target for most of the inhibitors used in the treatment of PCa. Currently, FDA approved drug, Abiraterone inhibits CYP17A1 activity, but it has few off-targets like drug-metabolizing CYPs as well as CYP21A2 which results in low cortisol levels in the body. Therefore, it is important to look for small non-steroid like molecules that can specifically inhibit CYP17A1 Lyase activity with reduced side effects.
研究兴趣
论文共 10 篇作者统计合作学者相似作者
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JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2023)
Tomasz M. Wrobel,Katyayani Sharma, Iole Mannella,Simonetta Oliaro-Bosso, Patrycja Nieckarz,Therina Du Toit,Clarissa Daniela Voegel,Maria Natalia Rojas Velazquez,Jibira Yakubu, Anna Matveeva,Soren Therkelsen,Flemming Steen Jorgensen,Amit V. Pandey,Agnese C. Pippione,Marco L. Lolli,Donatella Boschi,Fredrik Bjorkling
BIOMOLECULESno. 9 (2023): 1349-1349
Journal of medicinal chemistryno. 10 (2023): 6542-6566
Jimena Lopez Dacal,Nora Sanguineti,Roxana Marino,Pablo Ramirez,Natalia Perez Garrido,Elisa Vaiani,Maria Natalia Rojas Velazquez,Katyayani Sharma,Gabriela Guercio,Paula Scaglia,Maria Esnaola Azcoiti,Agustin Izquierdo,Gabriela Sanso,Marcela Bailez,Maria Gabriela Ropelato,Mariana Costanzo,Alicia Belgorosky,Ignacio Bergada,Rodolfo A. Rey,Amit V. Pandey,Romina P. Grinspon
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#Papers: 10
#Citation: 34
H-Index: 3
G-Index: 3
Sociability: 4
Diversity: 1
Activity: 6
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