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Molecular Mechanisms in Inherited Disorders of Platelet Signal Transduction (NIH and March of Dimes). A. Koneti Rao, MD [PI] - Patients with inherited platelet bleeding disorders are not uncommonly encountered in clinical practice. However, in the vast majority of these patients, the underlying molecular mechanisms leading to the platelet dysfunction are unknown. Our studies have focused on platelet signaling processes in these patients and have delineated hitherto undescribed abnormalities in key signaling proteins, including phospholipase C-beta-2, GTP binding protein G-alpha-q and protein kinase-C-theta. In addition we have focused over the last several years on the genes regulated in megakaryocytes and platelets by transcription factor RUNX1. Our studies show that MYL9. ALOX12, PF4, and PRKCQ are direct targets of RUNX1. The insights from these studies will lead to better understanding of the normal platelet mechanisms and the identification of novel targets to develop newer antiplatelet agents.
Molecular Mechanisms in Inherited Disorders of Platelet Signal Transduction (NIH and March of Dimes). A. Koneti Rao, MD [PI] - Patients with inherited platelet bleeding disorders are not uncommonly encountered in clinical practice. However, in the vast majority of these patients, the underlying molecular mechanisms leading to the platelet dysfunction are unknown. Our studies have focused on platelet signaling processes in these patients and have delineated hitherto undescribed abnormalities in key signaling proteins, including phospholipase C-beta-2, GTP binding protein G-alpha-q and protein kinase-C-theta. In addition we have focused over the last several years on the genes regulated in megakaryocytes and platelets by transcription factor RUNX1. Our studies show that MYL9. ALOX12, PF4, and PRKCQ are direct targets of RUNX1. The insights from these studies will lead to better understanding of the normal platelet mechanisms and the identification of novel targets to develop newer antiplatelet agents.
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Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature (2023)
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Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature (2022)
Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature (2022)
A Koneti Rao,Fabiola Del Carpio-Cano, Sumalaxmi Janapati,Huaqing Zhao,Helen Voelker, Xiaoning Lu,Gerard Criner
Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature (2021)
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