基本信息
浏览量:151
职业迁徙
个人简介
Dendritic cells are essential for presentation of foreign antigens to T cells to illicit an immune response. They sample their peripheral tissue environment by engulfing large volumes of the surrounding mileu by macropinocytosis. Macropinosomes form from the aggregation of many actin-driven ruffles. This process is down regulated in mature dendritic cells which migrate to secondary lymphoid organs for antigen presentation to T cells. During the initial encounter with antigen there is a brief burst of enhanced macropinocytosis accompanied by a loss of podosomes-cell substrate adhesive structures that are also actin rich. The main thrust of our research is to understand how these two types of actin structures are regulated. Novel regulators of the actin cytoskeleton will be identified and localised by advanced microscopy techniques. (Collaborative project with Colin Watts)
See Fig. A. below - Dendritic cell labelled for F-actin with phalloidin. Projection of a z-series colour coded for depth. Membrane ruffles associated with macropinosome formation rise up from the surface of the cell (coloured green and blue). Podosomes associated with the base of the cell near the substrate are coloured orange.
See Fig. A. below - Dendritic cell labelled for F-actin with phalloidin. Projection of a z-series colour coded for depth. Membrane ruffles associated with macropinosome formation rise up from the surface of the cell (coloured green and blue). Podosomes associated with the base of the cell near the substrate are coloured orange.
研究兴趣
论文共 327 篇作者统计合作学者相似作者
按年份排序按引用量排序主题筛选期刊级别筛选合作者筛选合作机构筛选
时间
引用量
主题
期刊级别
合作者
合作机构
Dipti Ranjan Lenka, Shakti Virendra Dahe,Odetta Antico,Pritiranjan Sahoo,Alan R Prescott,Miratul M K Muqit,Atul Kumar
eLife (2024)
Autophagy reportsno. 1 (2024)
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICAno. 20 (2023)
Journal of cell scienceno. 21 (2022)
JOURNAL OF CELL SCIENCEno. 6 (2022)
加载更多
作者统计
#Papers: 322
#Citation: 18180
H-Index: 72
G-Index: 127
Sociability: 7
Diversity: 3
Activity: 33
合作学者
合作机构
D-Core
- 合作者
- 学生
- 导师
数据免责声明
页面数据均来自互联网公开来源、合作出版商和通过AI技术自动分析结果,我们不对页面数据的有效性、准确性、正确性、可靠性、完整性和及时性做出任何承诺和保证。若有疑问,可以通过电子邮件方式联系我们:report@aminer.cn