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The main interest of our group is directed towards understanding underlying physical causes and biological mechanisms responsible for the spatial organization of genomes, starting with arrangements of DNA in phage capsids and ending with interphase chromosomes of higher eukaryotes. We are especially interested in the mechanism of formation of topologically associated domains (TADs) in eukaryotic chromosomes. We also study effects of such topological constraints as supercoiling and knotting on the properties of DNA molecules and chromatin fibers. We are also interested in the mechanism of folding and function of knotted proteins. Numerical simulations constitute the main method applied by our group.
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论文共 357 篇作者统计合作学者相似作者
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MOLECULESno. 22 (2023): 7462-7462
Annales Universitatis Mariae Curie-Sklodowska, sectio B – Geographia, Geologia, Mineralogia et Petrographia (2021): 95-125
Science Advancesno. 9 (2020)
Folia Turistica (2020): 99-127
Folia Turistica (2020): 99-127
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