基本信息
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职业迁徙
个人简介
Dr. Marcus is leading the effort to stimulate critical thinking and enthusiasm for sciences in children, kindergarten through 12th grade, in the state of Georgia. Along with Theresa Gillespie, PhD, he received a $1.2 million R25 Science Education Partnership Award (SEPA) from the National Institutes of Health in 2016. The grant led to the creation of the Center for Advancing Health and Diversity through Citizen Science where he serves as co-director.
Research
Dr. Marcus' laboratory studies how cancer cells invade and metastasize using a combination of molecular and imaging-based approaches. His work is focused on the lung cancer tumor suppressor protein and epithelial signaling protein, LKB1. This serine/threonine kinase is mutated in 30% of patients with non-small cell lung cancer; however, the functional significance of LKB1 loss in lung cancer is unknown. His group has shown that LKB1 plays a central role in cancer cell migration by behaving as a dynamic, actin-associated protein that regulates the cell polarity and adhesion pathway. Currently his work is focused on understanding how LKB1 mutations impact metastasis in mouse models and use this information to develop new treatments that can be specific for LKB1-inactivated tumors.
Dr. Marcus also focuses on developing natural compounds that preclude breast cancer cell metastasis and have minimal toxicity to normal cells. This work has identified the natural compound Withaferin A and its root extract as a potential anti-metastatic agent in breast cancer. A Phase 0 trial is currently under development using the root extract. His team envisions that this agent can be used in high-risk metastatic patients and/or combined with traditional cytotoxics to inhibit both metastasis and tumor growth.
Dr. Marcus' laboratory has been funded by National Cancer Institute, National Center for Complementary and Integrative Health, American Cancer Society, and private donations.
Research
Dr. Marcus' laboratory studies how cancer cells invade and metastasize using a combination of molecular and imaging-based approaches. His work is focused on the lung cancer tumor suppressor protein and epithelial signaling protein, LKB1. This serine/threonine kinase is mutated in 30% of patients with non-small cell lung cancer; however, the functional significance of LKB1 loss in lung cancer is unknown. His group has shown that LKB1 plays a central role in cancer cell migration by behaving as a dynamic, actin-associated protein that regulates the cell polarity and adhesion pathway. Currently his work is focused on understanding how LKB1 mutations impact metastasis in mouse models and use this information to develop new treatments that can be specific for LKB1-inactivated tumors.
Dr. Marcus also focuses on developing natural compounds that preclude breast cancer cell metastasis and have minimal toxicity to normal cells. This work has identified the natural compound Withaferin A and its root extract as a potential anti-metastatic agent in breast cancer. A Phase 0 trial is currently under development using the root extract. His team envisions that this agent can be used in high-risk metastatic patients and/or combined with traditional cytotoxics to inhibit both metastasis and tumor growth.
Dr. Marcus' laboratory has been funded by National Cancer Institute, National Center for Complementary and Integrative Health, American Cancer Society, and private donations.
研究兴趣
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Brajendra K. Tripathi,Nicole H. Hirsh, David Hansen, Xiaolan Qian, Marian E. Durkin,Dunrui Wang, Alex G. Papageorge, Ross Lake, Yvonne A. Evrard,Adam Marcus, Suresh S. Ramalingam, Mary Dasso,
Cancer Researchno. 6_Supplement (2024): 2089-2089
Cancer Researchno. 6_Supplement (2024): 1153-1153
Cancer Researchno. 5_Supplement (2023): P6-14
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MOLECULAR CANCER RESEARCHno. 5 (2023)
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Adam I. Marcus,Jun Zhou, Aurora O'Brate,Ernest Hamel, Jason Wong, Michael Nivens,Adel El-Naggar,Tso-Pang Yao,Fadlo R. Khuri,Paraskevi Giannakakou
crossref(2023)
biorxiv(2023)
CANCER RESEARCHno. 2 (2023): 314-315
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Molecular Cancer Researchno. 5_Supplement (2023): A027-A027
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Adam I. Marcus,Jun Zhou, Aurora O'Brate,Ernest Hamel, Jason Wong, Michael Nivens,Adel El-Naggar,Tso-Pang Yao,Fadlo R. Khuri,Paraskevi Giannakakou
crossref(2023)
bioRxiv : the preprint server for biology (2023)
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