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I am interested in the role of autophagy in sensing and controlling bacterial infection. Many intracellular bacteria are targeted and destroyed by autophagy and we would like to know how the cell senses their presence and the bacterial strategies for autophagy avoidance.
More broadly, I am studying the role of secreted bacterial effector proteins and their effects upon cell biology. I hope to gain new insights into bacterial pathogenesis and discover novel pathways by which bacteria manipulate host cell biology. Using high-throughput, high-content screening technologies we image and analyse hundreds of bacterial proteins in mammalian cells - selecting those producing alterations in cellular physiology. Such screening techniques allow us to analyse many bacterial proteins otherwise difficult to study due to lack of genetic or other tools.
More broadly, I am studying the role of secreted bacterial effector proteins and their effects upon cell biology. I hope to gain new insights into bacterial pathogenesis and discover novel pathways by which bacteria manipulate host cell biology. Using high-throughput, high-content screening technologies we image and analyse hundreds of bacterial proteins in mammalian cells - selecting those producing alterations in cellular physiology. Such screening techniques allow us to analyse many bacterial proteins otherwise difficult to study due to lack of genetic or other tools.
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Access Microbiologyno. 1A (2019)
Rosa Catania, Oran Maguire, Chris Moore,Franco H. Falcone,Weng Chan,Giuseppe Mantovani,Snow Stolnik,Alan Huett
Access Microbiologyno. 1A (2019)
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