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My research interests focus on clinical and experimental demyelinating disease with an emphasis on multiple sclerosis - the commonest potentially disabling disease of young adults. The research group has a broad set of interests: we work on the aetiology with international collaborations in genetics involving large-scale whole genome screens for factors that confer susceptibility and influence disease progression; in neurobiology, we study interactions between glia and axons, and the potential role of human stem cells as 'medicines' for limiting and the repairing the damage; our work in therapeutic immunology has used the monoclonal antibody Campath-1H (Alemtuzimab) both to treat patients and to understand mechanisms of tissue injury that determine the clinical course of the disease.
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The Lancet Neurologyno. 5 (2021): 338-338
Maria Ban,Wenjia Liao,Amie Baker,Alastair Compston,John Thorpe, Paul Molyneux, Mary Fraser,Jyoti Khadake,Joanne Jones,Alasdair Coles,Stephen Sawcer
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