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职业迁徙
个人简介
My research interests are within the field of mineralised connective tissues, focussing on the reparative potential and behaviour of the dentine-pulp complex and bone. I am interested in the signalling processes that initiate and control the repair of the dentine pulp complex, in particular the role and function of the dental pulp stem cells (DPSCs) in mediating this reparative process in. In addition, I am interested in the potential therapeutic roles of these DPSCs in the wider context of regenerative medicine, specifically neural repair and spinal cord injury and smooth muscle regeneration from bladder tissue repair and understanding their biological function in vitro and in situ and the heterogeneity in these cell populations.
Research is also focussed on understanding the dentinogenic and osteoinductive properties of dentine and bone matrices to facilitate novel tissue engineering methodologies and natural regenerative processes. Knowledge in these areas will allow us to develop ways of exploiting endogenous growth factor involvement in mineralised tissue repair for novel treatment modalities in restorative dentistry and implantology. This has allowed me to develop a research programme directly related to the development of novel clinical therapies and methods in relation to dentistry and orthopaedics regarding tissue regeneration and repair.
Research is also focussed on understanding the dentinogenic and osteoinductive properties of dentine and bone matrices to facilitate novel tissue engineering methodologies and natural regenerative processes. Knowledge in these areas will allow us to develop ways of exploiting endogenous growth factor involvement in mineralised tissue repair for novel treatment modalities in restorative dentistry and implantology. This has allowed me to develop a research programme directly related to the development of novel clinical therapies and methods in relation to dentistry and orthopaedics regarding tissue regeneration and repair.
研究兴趣
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Sim Yee Lim,Mali Dafydd, JieJi Ong, Launa A Ord-McDermott,Emma Board-Davies,Kirsty Sands,David Williams,Alastair J Sloan,Charles M Heard
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