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Our group is interested in understanding the metabolic adaptations that allow cancer cells to grow and proliferate, causing tumor growth. To understand how cancer cell metabolism works to fuel tumor growth, we use metabolomics techniques to catalog what nutrients are in the microenvironment of tumors. This provides us with a "menu" of nutrients that cancer cells could potentially metabolize to fuel their growth. Once we know the "menu" for different tumor types, we then use a variety of experimental tools from metabolomics to CRISPR gene editing to determine which nutrients cancer cells actually consume from the "menu", and which metabolic pathways process these nutrients. From these experiments, we are delineating the biochemical underpinnings of cancer cell growth.
Our group is interested in understanding the metabolic adaptations that allow cancer cells to grow and proliferate, causing tumor growth. To understand how cancer cell metabolism works to fuel tumor growth, we use metabolomics techniques to catalog what nutrients are in the microenvironment of tumors. This provides us with a "menu" of nutrients that cancer cells could potentially metabolize to fuel their growth. Once we know the "menu" for different tumor types, we then use a variety of experimental tools from metabolomics to CRISPR gene editing to determine which nutrients cancer cells actually consume from the "menu", and which metabolic pathways process these nutrients. From these experiments, we are delineating the biochemical underpinnings of cancer cell growth.
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论文共 65 篇作者统计合作学者相似作者
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Cancer discoveryno. 2 (2024): 348-361
Hao Fan,Siyuan Xia,Junhong Xiang,Yuancheng Li, Matthew O. Ross,Seon Ah Lim, Fan Yang, Jiayi Tu, Lishi Xie,Urszula Dougherty,Freya Q. Zhang,Zhong Zheng,
Natureno. 7989 (2023): 1034-1043
Juan J Apiz Saab, Lindsey N Dzierozynski,Patrick B Jonker,Roya AminiTabrizi, Hardik Shah,Rosa Elena Menjivar,Andrew J Scott,Zeribe C Nwosu,Zhou Zhu, Riona N Chen, Moses Oh,Colin Sheehan,
eLife (2023)
引用3浏览0WOS引用
3
0
Cancer Researchno. 7_Supplement (2023): 3136-3136
引用0浏览0引用
0
0
biorxiv(2023)
STAR PROTOCOLSno. 4 (2023): 102711-102711
Yogev Sela,Jinyang Li, Shivahamy Maheswaran,Robert Norgard,Salina Yuan,Maimon Hubbi,Miriam Doepner,Jimmy P. Xu,Elaine S. Ho,Clementina Mesaros,Colin Sheehan, Grace Croley,
crossref(2023)
Yogev Sela,Jinyang Li, Shivahamy Maheswaran,Robert Norgard,Salina Yuan,Maimon Hubbi,Miriam Doepner,Jimmy P. Xu,Elaine S. Ho,Clementina Mesaros,Colin Sheehan, Grace Croley,
crossref(2023)
biorxiv(2023)
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